Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
4E41
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Immune System
    Structure Weight: 189134.24
    Molecule: HLA class II histocompatibility antigen, DR alpha chain
    Polymer: 1 Type: protein Length: 182
    Chains: A, F
    Fragment: unp residues 26-207
    Organism: Homo sapiens
    Gene Names: Gene View for HLA-DRA HLA-DRA1
    UniProtKB: Protein Feature View | Search PDB | P01903  
    Molecule: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Polymer: 2 Type: protein Length: 190
    Chains: B, G
    Fragment: unp residues 30-219
    Organism: Homo sapiens
    Gene Name: Gene View for HLA-DRB1
    UniProtKB: Protein Feature View | Search PDB | P04229  
    Molecule: Triosephosphate isomerase
    Polymer: 3 Type: protein Length: 15
    Chains: C, H
    EC#: 5.3.1.1   
    Fragment: unp residues 60-74
    Organism: Homo sapiens
    Gene Names: Gene View for TPI1 TPI
    UniProtKB: Protein Feature View | Search PDB | P60174  
    Molecule: T cell receptor G4 alpha chain
    Polymer: 4 Type: protein Length: 203
    Chains: D, I
    Organism: Homo sapiens
    Molecule: T cell receptor G4 beta chain
    Polymer: 5 Type: protein Length: 239
    Chains: E, J
    Organism: Homo sapiens
     
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  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 3
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 4
    Scientific Name: Homo sapiens   Taxonomy   Expression System: Escherichia coli  
    Polymer: 5
    Scientific Name: Homo sapiens   Taxonomy   Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    4E42    
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    NA
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    NA Na
    SODIUM ION
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly 1       
Biological assembly 1 assigned by authors
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