4B7N
H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis
- PDB DOI: https://doi.org/10.2210/pdb4B7N/pdb
- Classification: HYDROLASE
- Organism(s): Influenza A virus (A/Netherlands/2631_1202/2010(H1N1))
- Expression System: Gallus gallus
- Mutation(s): No
- Deposited: 2012-08-21 Released: 2012-10-03
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.84 Å
- R-Value Free: 0.224
- R-Value Work: 0.185
- R-Value Observed: 0.187
This is version 1.4 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| NEURAMINIDASE | 469 | Influenza A virus (A/Netherlands/2631_1202/2010(H1N1)) | Mutation(s): 0 |  | |
UniProt | |||||
Find proteins for F8UU09 (Influenza A virus) Explore F8UU09 Go to UniProtKB: F8UU09 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | F8UU09 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ZMR Query on ZMR | E [auth A] | ZANAMIVIR C12 H20 N4 O7 ARAIBEBZBOPLMB-UFGQHTETSA-N |  | ||
| NAG Query on NAG | B [auth A], C [auth A], D [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
| CA Query on CA | F [auth A] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.84 Å
- R-Value Free: 0.224
- R-Value Work: 0.185
- R-Value Observed: 0.187
- Space Group: P 4 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 118.35 | α = 90 |
| b = 118.35 | β = 90 |
| c = 68.38 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| MOSFLM | data reduction |
| SCALA | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2012-10-03 Deposition Author(s): van der Vries, E., Vachieri, S.G., Xiong, X., Liu, J., Collins, P.J., Walker, P.A., Haire, L.F., Hay, A.J., Schutten, M., Osterhaus, A.D.M.E., Martin, S.R., Boucher, C.A.B., Skehel, J.J., Gamblin, S.J.
Revision History (Full details and data files)
- Version 1.0: 2012-10-03
Type: Initial release - Version 1.1: 2012-10-10
Changes: Database references - Version 1.2: 2012-12-12
Changes: Derived calculations - Version 1.3: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Advisory, Data collection, Derived calculations, Other, Structure summary - Version 1.4: 2023-12-20
Changes: Data collection, Database references, Refinement description, Structure summary
