4AY9

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.50 Å
  • R-Value Free: 0.269 
  • R-Value Work: 0.235 
  • R-Value Observed: 0.237 

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Ligand Structure Quality Assessment 


This is version 1.3 of the entry. See complete history. 



Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
GLYCOPROTEIN HORMONES, ALPHA POLYPEPTIDEA,
C [auth D],
E [auth G]		92Homo sapiensMutation(s): 0 
UniProt & NIH Common Fund Data Resources
Find proteins for P01215 (Homo sapiens)
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PHAROS:  P01215
GTEx:  ENSG00000135346 
Entity Groups  
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UniProt GroupP01215
Sequence Annotations
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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
FOLLITROPIN SUBUNIT BETAB,
D [auth E],
F [auth H]		111Homo sapiensMutation(s): 0 
UniProt & NIH Common Fund Data Resources
Find proteins for P01225 (Homo sapiens)
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PHAROS:  P01225
GTEx:  ENSG00000131808 
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UniProt GroupP01225
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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
FOLLICLE-STIMULATING HORMONE RECEPTORG [auth X],
H [auth Y],
I [auth Z]		350Homo sapiensMutation(s): 0 
UniProt & NIH Common Fund Data Resources
Find proteins for P23945 (Homo sapiens)
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PHAROS:  P23945
GTEx:  ENSG00000170820 
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UniProt GroupP23945
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  • Reference Sequence
Small Molecules
Ligands 1 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
NAG
Query on NAG
Download Ideal Coordinates CCD File 
J [auth A]
K [auth A]
L [auth B]
M [auth B]
N [auth D]
J [auth A],
K [auth A],
L [auth B],
M [auth B],
N [auth D],
O [auth D],
P [auth E],
Q [auth E],
R [auth G],
S [auth G],
T [auth H],
U [auth H],
V [auth X],
W [auth Y],
X [auth Z]
2-acetamido-2-deoxy-beta-D-glucopyranose
C8 H15 N O6
OVRNDRQMDRJTHS-FMDGEEDCSA-N
Modified Residues  1 Unique
IDChains TypeFormula2D DiagramParent
TYS
Query on TYS		G [auth X],
H [auth Y],
I [auth Z]		L-PEPTIDE LINKINGC9 H11 N O6 STYR
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.50 Å
  • R-Value Free: 0.269 
  • R-Value Work: 0.235 
  • R-Value Observed: 0.237 
  • Space Group: P 1
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 70.716α = 60.3
b = 95.478β = 80.02
c = 95.675γ = 75.35
Software Package:
Software NamePurpose
REFMACrefinement
HKL-3000data reduction
XSCALEdata scaling
PHASERphasing

Structure Validation

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Ligand Structure Quality Assessment 


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Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2012-08-08
    Type: Initial release
  • Version 1.1: 2012-08-15
    Changes: Database references
  • Version 1.2: 2020-07-29
    Type: Remediation
    Reason: Carbohydrate remediation
    Changes: Data collection, Derived calculations, Other, Structure summary
  • Version 1.3: 2023-12-20
    Changes: Data collection, Database references, Refinement description, Structure summary