HLA-DR1 with covalently linked CLIP106-120 in canonical orientation
4AH2
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Immune System
    Structure Weight: 48471.88
    Molecule: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
    Polymer: 1 Type: protein Length: 193
    Chains: A
    Fragment: EXTRACELLULAR DOMAIN, RESIDUES 26-217
    Organism: Homo sapiens
    Gene Names: Gene View for HLA-DRA HLA-DRA1
    UniProtKB: Protein Feature View | Search PDB | P01903  
    Molecule: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN\,DRB1-1 BETA CHAIN
    Polymer: 2 Type: protein Length: 229
    Chains: B
    Fragment: EXTRACELLULAR DOMAIN, RESIDUES 106-120,30-227
    Organism: Homo sapiens
    Gene Names: Gene View for HLA-DRB1 Gene View for CD74 DHLAG
    UniProtKB: Protein Feature View | Search PDB | P04229  

    UniProtKB: Protein Feature View | Search PDB | P04233  
     
  •   Structure Validation Hide

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  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Homo sapiens, homo sapiens   Taxonomy   Common Name: Human, human Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1A6A   THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3 
    1AQD   HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITYPROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUSPEPTIDE 
    1D5M   X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDE 
    1D5X   X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC 
    1D5Z   X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC 
    1D6E   CRYSTAL STRUCTURE OF HLA-DR4 COMPLEX WITH PEPTIDOMIMETIC AND SEB 
    1DLH    
    1FV1   STRUCTURAL BASIS FOR THE BINDING OF AN IMMUNODOMINANTPEPTIDE FROM MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BYTWO HLA-DR2 ALLELES 
    1FYT   CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA -T CELLRECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS IIMOLECULE, HLA-DR1 
    1H15   X-RAY CRYSTAL STRUCTURE OF HLA-DRA1*0101/DRB5*0101 COMPLEXED WITH A PEPTIDE FROM EPSTEIN BARR VIRUS DNA POLYMERASE. 
    1HXY   CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H INCOMPLEX WITH HUMAN MHC CLASS II 
    1ICF   CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L 
    1IIE   MHC CLASS II-ASSOCIATED INVARIANT CHAIN (II) HUMAN ECTOPLASMIC TRIMERIZATION DOMAIN 
    1J8H   CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA -T CELLRECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS IIMOLECULE, HLA-DR4 
    1JWM   CRYSTAL STRUCTURE OF THE COMPLEX OF THE MHC CLASS IIMOLECULE HLA-DR1(HA PEPTIDE 306-318) WITH THE SUPERANTIGENSEC3 
    1JWS   CRYSTAL STRUCTURE OF THE COMPLEX OF THE MHC CLASS IIMOLECULE HLA-DR1 (HA PEPTIDE 306-318) WITH THESUPERANTIGEN SEC3 VARIANT 3B1 
    1JWU   CRYSTAL STRUCTURE OF THE COMPLEX OF THE MHC CLASS IIMOLECULE HLA-DR1 (HA PEPTIDE 306-318) WITH THESUPERANTIGEN SEC3 VARIANT 3B2 
    1KG0   STRUCTURE OF THE EPSTEIN-BARR VIRUS GP42 PROTEIN BOUND TOTHE MHC CLASS II RECEPTOR HLA-DR1 
    1KLG   CRYSTAL STRUCTURE OF HLA-DR1/TPI(23-37, THR28-->ILE MUTANT)COMPLEXED WITH STAPHYLOCOCCAL ENTEROTOXIN C3 VARIANT 3B2(SEC3-3B2) 
    1KLU   CRYSTAL STRUCTURE OF HLA-DR1/TPI(23-37) COMPLEXED WITHSTAPHYLOCOCCAL ENTEROTOXIN C3 VARIANT 3B2 (SEC3-3B2) 
    1L3H   NMR STRUCTURE OF P41ICF, A POTENT INHIBITOR OF HUMANCATHEPSIN L 
    1LO5   CRYSTAL STRUCTURE OF THE D227A VARIANT OF STAPHYLOCOCCALENTEROTOXIN A IN COMPLEX WITH HUMAN MHC CLASS II 
    1MUJ   CRYSTAL STRUCTURE OF MURINE CLASS II MHC I-AB IN COMPLEXWITH A HUMAN CLIP PEPTIDE 
    1SEB   COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA- DR1 ANDTHE BACTERIAL SUPERANTIGEN SEB 
    1SJE   HLA-DR1 COMPLEXED WITH A 16 RESIDUE HIV CAPSID PEPTIDEBOUND IN A HAIRPIN CONFORMATION 
    1SJH   HLA-DR1 COMPLEXED WITH A 13 RESIDUE HIV CAPSID PEPTIDE 
    1T5W   HLA-DR1 IN COMPLEX WITH A SYNTHETIC PEPTIDE( AAYSDQATPLLLSPR) 
    1T5X   HLA-DR1 IN COMPLEX WITH A SYNTHETIC PEPTIDE( AAYSDQATPLLLSPR) AND THE SUPERANTIGEN SEC3-3B2 
    1YMM   TCR/HLA-DR2B/MBP-PEPTIDE COMPLEX 
    1ZGL   CRYSTAL STRUCTURE OF 3A6 TCR BOUND TO MBP/HLA-DR2A 
    2G9H   CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN I (SEI) INCOMPLEX WITH A HUMAN MHC CLASS II MOLECULE 
    2SEB   X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II 
    2XN9   CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN HUMAN T CELL RECEPTOR, STAPHYLOCOCCAL ENTEROTOXIN H AND HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II 
    3PDO   CRYSTAL STRUCTURE OF HLA-DR1 WITH CLIP102-120 
    3PGC   CRYSTAL STRUCTURE OF HLA-DR1 WITH CLIP106-120, FLIPPED PEPTIDE ORIENTATION 
    3PGD   CRYSTAL STRUCTURE OF HLA-DR1 WITH CLIP106-120, CANONICAL PEPTIDE ORIENTATION 
    4AEN   HLA-DR1 WITH COVALENTLY LINKED CLIP106-120 IN REVERSED ORIENTATION 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    GOL
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    GOL C3 H8 O3
    GLYCEROL
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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