4WST

The crystal structure of hemagglutinin from A/Taiwan/1/2013 influenza virus

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.40 Å
  • R-Value Free: 0.253 
  • R-Value Work: 0.222 
  • R-Value Observed: 0.223 

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This is version 1.3 of the entry. See complete history. 


Literature

Structure and receptor binding preferences of recombinant hemagglutinins from avian and human h6 and h10 influenza a virus subtypes.

Yang, H., Carney, P.J., Chang, J.C., Villanueva, J.M., Stevens, J.

(2015) J Virol 89: 4612-4623

  • DOI: https://doi.org/10.1128/JVI.03456-14
  • Primary Citation of Related Structures:  
    4WSR, 4WST, 4WSV

  • PubMed Abstract: 

    During 2013, three new avian influenza A virus subtypes, A(H7N9), A(H6N1), and A(H10N8), resulted in human infections. While the A(H7N9) virus resulted in a significant epidemic in China across 19 provinces and municipalities, both A(H6N1) and A(H10N8) viruses resulted in only a few human infections. This study focuses on the major surface glycoprotein hemagglutinins from both of these novel human viruses. The detailed structural and glycan microarray analyses presented here highlight the idea that both A(H6N1) and A(H10N8) virus hemagglutinins retain a strong avian receptor binding preference and thus currently pose a low risk for sustained human infections.

    • Organizational Affiliation: 

    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.


Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Hemagglutinin HA1 chain
A, C, E, G, I
A, C, E, G, I, K
334Influenza A virusMutation(s): 0 
UniProt
Find proteins for A0A0J9X246 (Influenza A virus)
Explore A0A0J9X246 
Go to UniProtKB:  A0A0J9X246
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupA0A0J9X246
Sequence Annotations
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  • Reference Sequence
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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
Hemagglutinin HA2 chain
B, D, F, H, J
B, D, F, H, J, L
181Influenza A virusMutation(s): 0 
UniProt
Find proteins for A0A0J9X245 (Influenza A virus)
Explore A0A0J9X245 
Go to UniProtKB:  A0A0J9X245
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupA0A0J9X245
Sequence Annotations
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  • Reference Sequence
Small Molecules
Ligands 1 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
NAG
Query on NAG
Download Ideal Coordinates CCD File 
AA [auth I]
BA [auth K]
CA [auth K]
DA [auth K]
M [auth A]
AA [auth I],
BA [auth K],
CA [auth K],
DA [auth K],
M [auth A],
N [auth A],
O [auth A],
P [auth C],
Q [auth C],
R [auth C],
S [auth E],
T [auth E],
U [auth E],
V [auth G],
W [auth G],
X [auth G],
Y [auth I],
Z [auth I]
2-acetamido-2-deoxy-beta-D-glucopyranose
C8 H15 N O6
OVRNDRQMDRJTHS-FMDGEEDCSA-N
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.40 Å
  • R-Value Free: 0.253 
  • R-Value Work: 0.222 
  • R-Value Observed: 0.223 
  • Space Group: C 1 2 1
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 226.63α = 90
b = 100.612β = 99.66
c = 175.477γ = 90
Software Package:
Software NamePurpose
REFMACrefinement

Structure Validation

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Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2015-02-25
    Type: Initial release
  • Version 1.1: 2015-04-01
    Changes: Database references
  • Version 1.2: 2020-07-29
    Type: Remediation
    Reason: Carbohydrate remediation
    Changes: Advisory, Data collection, Database references, Derived calculations, Source and taxonomy, Structure summary
  • Version 1.3: 2023-12-27
    Changes: Data collection, Database references, Refinement description, Structure summary