4WQU

Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin


Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.80 Å
  • R-Value Free: 0.264 
  • R-Value Work: 0.209 
  • R-Value Observed: 0.212 

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This is version 2.2 of the entry. See complete history


Literature

Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.

Lin, J.Gagnon, M.G.Bulkley, D.Steitz, T.A.

(2015) Cell 160: 219-227

  • DOI: https://doi.org/10.1016/j.cell.2014.11.049
  • Primary Citation of Related Structures:  
    4WPO, 4WQF, 4WQU, 4WQY

  • PubMed Abstract: 

    The universally conserved GTPase elongation factor G (EF-G) catalyzes the translocation of tRNA and mRNA on the ribosome after peptide bond formation. Despite numerous studies suggesting that EF-G undergoes extensive conformational rearrangements during translocation, high-resolution structures exist for essentially only one conformation of EF-G in complex with the ribosome. Here, we report four atomic-resolution crystal structures of EF-G bound to the ribosome programmed in the pre- and posttranslocational states and to the ribosome trapped by the antibiotic dityromycin. We observe a previously unseen conformation of EF-G in the pretranslocation complex, which is independently captured by dityromycin on the ribosome. Our structures provide insights into the conformational space that EF-G samples on the ribosome and reveal that tRNA translocation on the ribosome is facilitated by a structural transition of EF-G from a compact to an elongated conformation, which can be prevented by the antibiotic dityromycin.


  • Organizational Affiliation

    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA.


Macromolecules

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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L1C [auth AC],
JB [auth CC]
228Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L2D [auth AD],
KB [auth CD]
276Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L3E [auth AE],
LB [auth CE]
206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L4F [auth AF],
MB [auth CF]
210Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L5G [auth AG],
NB [auth CG]
182Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L6H [auth AH],
OB [auth CH]
180Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L10I [auth AK],
PB [auth CK]
173Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L11J [auth AL],
QB [auth CL]
147Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L13K [auth AN],
RB [auth CN]
140Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L14L [auth AO],
SB [auth CO]
122Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L15M [auth AP],
TB [auth CP]
150Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L16N [auth AQ],
UB [auth CQ]
141Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L17O [auth AR],
VB [auth CR]
118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L18P [auth AS],
WB [auth CS]
112Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L19Q [auth AT],
XB [auth CT]
146Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L20R [auth AU],
YB [auth CU]
118Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L21S [auth AV],
ZB [auth CV]
101Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L22AC [auth CW],
T [auth AW]
113Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L23BC [auth CX],
U [auth AX]
96Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 22
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L24CC [auth CY],
V [auth AY]
110Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 23
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L25DC [auth CZ],
W [auth AZ]
206Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 24
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L27EC [auth C0],
X [auth A0]
85Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 25
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L28FC [auth C1],
Y [auth A1]
98Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 26
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L29GC [auth C2],
Z [auth A2]
72Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 27
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L30AA [auth A3],
HC [auth C3]
60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 28
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L31BA [auth A4],
IC [auth C4]
71Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L32CA [auth A5],
JC [auth C5]
60Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L33DA [auth A6],
KC [auth C6]
54Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 31
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L34EA [auth A7],
LC [auth C7]
49Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 32
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L35FA [auth A8],
MC [auth C8]
65Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L36GA [auth A9],
NC [auth C9]
37Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S2IA [auth BB],
PC [auth DB]
256Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S3JA [auth BC],
QC [auth DC]
239Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S4KA [auth BD],
RC [auth DD]
209Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S5LA [auth BE],
SC [auth DE]
162Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S6MA [auth BF],
TC [auth DF]
101Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S7NA [auth BG],
UC [auth DG]
156Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S8OA [auth BH],
VC [auth DH]
138Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S9PA [auth BI],
WC [auth DI]
128Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S10QA [auth BJ],
XC [auth DJ]
105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S11RA [auth BK],
YC [auth DK]
129Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S12SA [auth BL],
ZC [auth DL]
132Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SHN3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 46
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S13AD [auth DM],
TA [auth BM]
126Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S14 type ZBD [auth DN],
UA [auth BN]
61Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S15CD [auth DO],
VA [auth BO]
89Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SJ76 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S16DD [auth DP],
WA [auth BP]
88Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SJH3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S17ED [auth DQ],
XA [auth BQ]
105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S18FD [auth DR],
YA [auth BR]
88Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SLQ0 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 52
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S19GD [auth DS],
ZA [auth BS]
93Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SHP2 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 53
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S20AB [auth BT],
HD [auth DT]
106Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for P80380 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 54
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein ThxBB [auth BU],
ID [auth DU]
27Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SIH3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 57
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L9,Elongation factor GFB [auth BZ],
MD [auth DZ]
758Thermus thermophilus HB8Mutation(s): 0 
Gene Names: rplITTHA0242fusAfusTTHA1695
UniProt
Find proteins for Q5SLQ1 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Find proteins for Q5SHN5 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 58
MoleculeChains Sequence LengthOrganismDetailsImage
DityromycinGB [auth BX],
ND [auth DX]
10Streptomyces sp.Mutation(s): 0 
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Entity ID: 1
MoleculeChains LengthOrganismImage
23S Ribosomal RNAA [auth AA],
HB [auth CA]
2,915Thermus thermophilus HB8
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Entity ID: 2
MoleculeChains LengthOrganismImage
5S Ribosomal RNAB [auth AB],
IB [auth CB]
121Thermus thermophilus HB8
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Entity ID: 34
MoleculeChains LengthOrganismImage
16S Ribosomal RNAHA [auth BA],
OC [auth DA]
1,521Thermus thermophilus HB8
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Entity ID: 55
MoleculeChains LengthOrganismImage
mRNACB [auth BV],
JD [auth DV]
18synthetic construct
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Entity ID: 56
MoleculeChains LengthOrganismImage
P-site tRNADB [auth BW],
EB [auth BY],
KD [auth DW],
LD [auth DY]
76Escherichia coli str. K-12 substr. MC4100
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Small Molecules
Ligands 4 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
GDP
Query on GDP

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PEC [auth DZ],
YVA [auth BZ]
GUANOSINE-5'-DIPHOSPHATE
C10 H15 N5 O11 P2
QGWNDRXFNXRZMB-UUOKFMHZSA-N
SF4
Query on SF4

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BEC [auth DD],
HVA [auth BD]
IRON/SULFUR CLUSTER
Fe4 S4
LJBDFODJNLIPKO-UHFFFAOYSA-N
ZN
Query on ZN

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BXB [auth CY]
FXB [auth C4]
GMA [auth AY]
HXB [auth C5]
IEC [auth DN]
BXB [auth CY],
FXB [auth C4],
GMA [auth AY],
HXB [auth C5],
IEC [auth DN],
IXB [auth C6],
LXB [auth C9],
PMA [auth A4],
PVA [auth BN],
QMA [auth A5],
TMA [auth A6],
XMA [auth A9]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
MG
Query on MG

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AAA [auth AA]
AAB [auth CA]
AAC [auth DA]
ABA [auth AA]
ABB [auth CA]
AAA [auth AA],
AAB [auth CA],
AAC [auth DA],
ABA [auth AA],
ABB [auth CA],
ABC [auth DA],
ACA [auth AA],
ACB [auth CA],
ACC [auth DA],
ADA [auth AA],
ADB [auth CA],
ADC [auth DA],
AE [auth AA],
AEA [auth AA],
AEB [auth CA],
AEC [auth DA],
AF [auth AA],
AFA [auth AA],
AFB [auth CA],
AG [auth AA],
AGA [auth AA],
AGB [auth CA],
AH [auth AA],
AHA [auth AA],
AHB [auth CA],
AI [auth AA],
AIA [auth AA],
AIB [auth CA],
AJ [auth AA],
AJA [auth AA],
AJB [auth CA],
AK [auth AA],
AKA [auth AB],
AKB [auth CA],
AL [auth AA],
ALA [auth AF],
ALB [auth CA],
AM [auth AA],
AMA [auth AV],
AMB [auth CA],
AN [auth AA],
ANA [auth BA],
ANB [auth CA],
AO [auth AA],
AOA [auth BA],
AOB [auth CA],
AP [auth AA],
APA [auth BA],
APB [auth CA],
AQ [auth AA],
AQA [auth BA],
AQB [auth CA],
AR [auth AA],
ARA [auth BA],
ARB [auth CA],
AS [auth AA],
ASA [auth BA],
ASB [auth CA],
AT [auth AA],
ATA [auth BA],
ATB [auth CA],
AU [auth AA],
AUA [auth BA],
AUB [auth CA],
AV [auth AA],
AVA [auth BA],
AVB [auth CA],
AW [auth AA],
AWA [auth CA],
AWB [auth CD],
AX [auth AA],
AXA [auth CA],
AXB [auth CX],
AY [auth AA],
AYA [auth CA],
AYB [auth DA],
AZ [auth AA],
AZA [auth CA],
AZB [auth DA],
BAA [auth AA],
BAB [auth CA],
BAC [auth DA],
BBA [auth AA],
BBB [auth CA],
BBC [auth DA],
BCA [auth AA],
BCB [auth CA],
BCC [auth DA],
BDA [auth AA],
BDB [auth CA],
BDC [auth DA],
BE [auth AA],
BEA [auth AA],
BEB [auth CA],
BF [auth AA],
BFA [auth AA],
BFB [auth CA],
BG [auth AA],
BGA [auth AA],
BGB [auth CA],
BH [auth AA],
BHA [auth AA],
BHB [auth CA],
BI [auth AA],
BIA [auth AA],
BIB [auth CA],
BJ [auth AA],
BJA [auth AA],
BJB [auth CA],
BK [auth AA],
BKA [auth AB],
BKB [auth CA],
BL [auth AA],
BLA [auth AF],
BLB [auth CA],
BM [auth AA],
BMA [auth AV],
BMB [auth CA],
BN [auth AA],
BNA [auth BA],
BNB [auth CA],
BO [auth AA],
BOA [auth BA],
BOB [auth CA],
BP [auth AA],
BPA [auth BA],
BPB [auth CA],
BQ [auth AA],
BQA [auth BA],
BQB [auth CA],
BR [auth AA],
BRA [auth BA],
BRB [auth CA],
BS [auth AA],
BSA [auth BA],
BSB [auth CA],
BT [auth AA],
BTA [auth BA],
BTB [auth CA],
BU [auth AA],
BUA [auth BA],
BUB [auth CA],
BV [auth AA],
BVA [auth BA],
BVB [auth CA],
BW [auth AA],
BWA [auth CA],
BWB [auth CD],
BX [auth AA],
BXA [auth CA],
BY [auth AA],
BYA [auth CA],
BYB [auth DA],
BZ [auth AA],
BZA [auth CA],
BZB [auth DA],
CAA [auth AA],
CAB [auth CA],
CAC [auth DA],
CBA [auth AA],
CBB [auth CA],
CBC [auth DA],
CCA [auth AA],
CCB [auth CA],
CCC [auth DA],
CDA [auth AA],
CDB [auth CA],
CDC [auth DA],
CE [auth AA],
CEA [auth AA],
CEB [auth CA],
CEC [auth DD],
CF [auth AA],
CFA [auth AA],
CFB [auth CA],
CG [auth AA],
CGA [auth AA],
CGB [auth CA],
CH [auth AA],
CHA [auth AA],
CHB [auth CA],
CI [auth AA],
CIA [auth AA],
CIB [auth CA],
CJ [auth AA],
CJA [auth AA],
CJB [auth CA],
CK [auth AA],
CKA [auth AB],
CKB [auth CA],
CL [auth AA],
CLA [auth AF],
CLB [auth CA],
CM [auth AA],
CMA [auth AW],
CMB [auth CA],
CN [auth AA],
CNA [auth BA],
CNB [auth CA],
CO [auth AA],
COA [auth BA],
COB [auth CA],
CP [auth AA],
CPA [auth BA],
CPB [auth CA],
CQ [auth AA],
CQA [auth BA],
CQB [auth CA],
CR [auth AA],
CRA [auth BA],
CRB [auth CA],
CS [auth AA],
CSA [auth BA],
CSB [auth CA],
CT [auth AA],
CTA [auth BA],
CTB [auth CA],
CU [auth AA],
CUA [auth BA],
CUB [auth CA],
CV [auth AA],
CVA [auth BA],
CVB [auth CA],
CW [auth AA],
CWA [auth CA],
CWB [auth CD],
CX [auth AA],
CXA [auth CA],
CXB [auth C0],
CY [auth AA],
CYA [auth CA],
CYB [auth DA],
CZ [auth AA],
CZA [auth CA],
CZB [auth DA],
DAA [auth AA],
DAB [auth CA],
DAC [auth DA],
DBA [auth AA],
DBB [auth CA],
DBC [auth DA],
DCA [auth AA],
DCB [auth CA],
DCC [auth DA],
DDA [auth AA],
DDB [auth CA],
DDC [auth DA],
DE [auth AA],
DEA [auth AA],
DEB [auth CA],
DEC [auth DE],
DF [auth AA],
DFA [auth AA],
DFB [auth CA],
DG [auth AA],
DGA [auth AA],
DGB [auth CA],
DH [auth AA],
DHA [auth AA],
DHB [auth CA],
DI [auth AA],
DIA [auth AA],
DIB [auth CA],
DJ [auth AA],
DJA [auth AA],
DJB [auth CA],
DK [auth AA],
DKA [auth AB],
DKB [auth CA],
DL [auth AA],
DLA [auth AF],
DLB [auth CA],
DM [auth AA],
DMA [auth AW],
DMB [auth CA],
DN [auth AA],
DNA [auth BA],
DNB [auth CA],
DO [auth AA],
DOA [auth BA],
DOB [auth CA],
DP [auth AA],
DPA [auth BA],
DPB [auth CA],
DQ [auth AA],
DQA [auth BA],
DQB [auth CA],
DR [auth AA],
DRA [auth BA],
DRB [auth CA],
DS [auth AA],
DSA [auth BA],
DSB [auth CA],
DT [auth AA],
DTA [auth BA],
DTB [auth CA],
DU [auth AA],
DUA [auth BA],
DUB [auth CA],
DV [auth AA],
DVA [auth BA],
DVB [auth CA],
DW [auth AA],
DWA [auth CA],
DWB [auth CD],
DX [auth AA],
DXA [auth CA],
DXB [auth C1],
DY [auth AA],
DYA [auth CA],
DYB [auth DA],
DZ [auth AA],
DZA [auth CA],
DZB [auth DA],
EAA [auth AA],
EAB [auth CA],
EAC [auth DA],
EBA [auth AA],
EBB [auth CA],
EBC [auth DA],
ECA [auth AA],
ECB [auth CA],
ECC [auth DA],
EDA [auth AA],
EDB [auth CA],
EDC [auth DA],
EE [auth AA],
EEA [auth AA],
EEB [auth CA],
EEC [auth DE],
EF [auth AA],
EFA [auth AA],
EFB [auth CA],
EG [auth AA],
EGA [auth AA],
EGB [auth CA],
EH [auth AA],
EHA [auth AA],
EHB [auth CA],
EI [auth AA],
EIA [auth AA],
EIB [auth CA],
EJ [auth AA],
EJA [auth AA],
EJB [auth CA],
EK [auth AA],
EKA [auth AB],
EKB [auth CA],
EL [auth AA],
ELA [auth AF],
ELB [auth CA],
EM [auth AA],
EMA [auth AW],
EMB [auth CA],
EN [auth AA],
ENA [auth BA],
ENB [auth CA],
EO [auth AA],
EOA [auth BA],
EOB [auth CA],
EP [auth AA],
EPA [auth BA],
EPB [auth CA],
EQ [auth AA],
EQA [auth BA],
EQB [auth CA],
ER [auth AA],
ERA [auth BA],
ERB [auth CA],
ES [auth AA],
ESA [auth BA],
ESB [auth CA],
ET [auth AA],
ETA [auth BA],
ETB [auth CA],
EU [auth AA],
EUA [auth BA],
EUB [auth CA],
EV [auth AA],
EVA [auth BA],
EVB [auth CA],
EW [auth AA],
EWA [auth CA],
EWB [auth CE],
EX [auth AA],
EXA [auth CA],
EXB [auth C3],
EY [auth AA],
EYA [auth CA],
EYB [auth DA],
EZ [auth AA],
EZA [auth CA],
EZB [auth DA],
FAA [auth AA],
FAB [auth CA],
FAC [auth DA],
FBA [auth AA],
FBB [auth CA],
FBC [auth DA],
FCA [auth AA],
FCB [auth CA],
FCC [auth DA],
FDA [auth AA],
FDB [auth CA],
FDC [auth DA],
FE [auth AA],
FEA [auth AA],
FEB [auth CA],
FEC [auth DF],
FF [auth AA],
FFA [auth AA],
FFB [auth CA],
FG [auth AA],
FGA [auth AA],
FGB [auth CA],
FH [auth AA],
FHA [auth AA],
FHB [auth CA],
FI [auth AA],
FIA [auth AA],
FIB [auth CA],
FJ [auth AA],
FJA [auth AA],
FJB [auth CA],
FK [auth AA],
FKA [auth AB],
FKB [auth CA],
FL [auth AA],
FLA [auth AF],
FLB [auth CA],
FM [auth AA],
FMA [auth AX],
FMB [auth CA],
FN [auth AA],
FNA [auth BA],
FNB [auth CA],
FO [auth AA],
FOA [auth BA],
FOB [auth CA],
FP [auth AA],
FPA [auth BA],
FPB [auth CA],
FQ [auth AA],
FQA [auth BA],
FQB [auth CA],
FR [auth AA],
FRA [auth BA],
FRB [auth CA],
FS [auth AA],
FSA [auth BA],
FSB [auth CA],
FT [auth AA],
FTA [auth BA],
FTB [auth CA],
FU [auth AA],
FUA [auth BA],
FUB [auth CA],
FV [auth AA],
FVA [auth BA],
FVB [auth CA],
FW [auth AA],
FWA [auth CA],
FWB [auth CE],
FX [auth AA],
FXA [auth CA],
FY [auth AA],
FYA [auth CA],
FYB [auth DA],
FZ [auth AA],
FZA [auth CA],
FZB [auth DA],
GAA [auth AA],
GAB [auth CA],
GAC [auth DA],
GBA [auth AA],
GBB [auth CA],
GBC [auth DA],
GCA [auth AA],
GCB [auth CA],
GCC [auth DA],
GDA [auth AA],
GDB [auth CA],
GDC [auth DA],
GE [auth AA],
GEA [auth AA],
GEB [auth CA],
GEC [auth DJ],
GF [auth AA],
GFA [auth AA],
GFB [auth CA],
GG [auth AA],
GGA [auth AA],
GGB [auth CA],
GH [auth AA],
GHA [auth AA],
GHB [auth CA],
GI [auth AA],
GIA [auth AA],
GIB [auth CA],
GJ [auth AA],
GJA [auth AA],
GJB [auth CA],
GK [auth AA],
GKA [auth AB],
GKB [auth CA],
GL [auth AA],
GLA [auth AG],
GLB [auth CA],
GM [auth AA],
GMB [auth CA],
GN [auth AA],
GNA [auth BA],
GNB [auth CA],
GO [auth AA],
GOA [auth BA],
GOB [auth CA],
GP [auth AA],
GPA [auth BA],
GPB [auth CA],
GQ [auth AA],
GQA [auth BA],
GQB [auth CA],
GR [auth AA],
GRA [auth BA],
GRB [auth CA],
GS [auth AA],
GSA [auth BA],
GSB [auth CA],
GT [auth AA],
GTA [auth BA],
GTB [auth CA],
GU [auth AA],
GUA [auth BA],
GUB [auth CA],
GV [auth AA],
GVA [auth BB],
GVB [auth CA],
GW [auth AA],
GWA [auth CA],
GWB [auth CE],
GX [auth AA],
GXA [auth CA],
GXB [auth C5],
GY [auth AA],
GYA [auth CA],
GYB [auth DA],
GZ [auth AA],
GZA [auth CA],
GZB [auth DA],
HAA [auth AA],
HAB [auth CA],
HAC [auth DA],
HBA [auth AA],
HBB [auth CA],
HBC [auth DA],
HCA [auth AA],
HCB [auth CA],
HCC [auth DA],
HDA [auth AA],
HDB [auth CA],
HDC [auth DA],
HE [auth AA],
HEA [auth AA],
HEB [auth CA],
HEC [auth DK],
HF [auth AA],
HFA [auth AA],
HFB [auth CA],
HG [auth AA],
HGA [auth AA],
HGB [auth CA],
HH [auth AA],
HHA [auth AA],
HHB [auth CA],
HI [auth AA],
HIA [auth AA],
HIB [auth CA],
HJ [auth AA],
HJA [auth AA],
HJB [auth CA],
HK [auth AA],
HKA [auth AB],
HKB [auth CA],
HL [auth AA],
HLA [auth AG],
HLB [auth CA],
HM [auth AA],
HMA [auth AY],
HMB [auth CA],
HN [auth AA],
HNA [auth BA],
HNB [auth CA],
HO [auth AA],
HOA [auth BA],
HOB [auth CA],
HP [auth AA],
HPA [auth BA],
HPB [auth CA],
HQ [auth AA],
HQA [auth BA],
HQB [auth CA],
HR [auth AA],
HRA [auth BA],
HRB [auth CA],
HS [auth AA],
HSA [auth BA],
HSB [auth CA],
HT [auth AA],
HTA [auth BA],
HTB [auth CA],
HU [auth AA],
HUA [auth BA],
HUB [auth CA],
HV [auth AA],
HVB [auth CA],
HW [auth AA],
HWA [auth CA],
HWB [auth CE],
HX [auth AA],
HXA [auth CA],
HY [auth AA],
HYA [auth CA],
HYB [auth DA],
HZ [auth AA],
HZA [auth CA],
HZB [auth DA],
IAA [auth AA],
IAB [auth CA],
IAC [auth DA],
IBA [auth AA],
IBB [auth CA],
IBC [auth DA],
ICA [auth AA],
ICB [auth CA],
ICC [auth DA],
IDA [auth AA],
IDB [auth CA],
IDC [auth DA],
IE [auth AA],
IEA [auth AA],
IEB [auth CA],
IF [auth AA],
IFA [auth AA],
IFB [auth CA],
IG [auth AA],
IGA [auth AA],
IGB [auth CA],
IH [auth AA],
IHA [auth AA],
IHB [auth CA],
II [auth AA],
IIA [auth AA],
IIB [auth CA],
IJ [auth AA],
IJA [auth AA],
IJB [auth CA],
IK [auth AA],
IKA [auth AB],
IKB [auth CA],
IL [auth AA],
ILA [auth AH],
ILB [auth CA],
IM [auth AA],
IMA [auth AZ],
IMB [auth CA],
IN [auth AA],
INA [auth BA],
INB [auth CA],
IO [auth AA],
IOA [auth BA],
IOB [auth CA],
IP [auth AA],
IPA [auth BA],
IPB [auth CA],
IQ [auth AA],
IQA [auth BA],
IQB [auth CA],
IR [auth AA],
IRA [auth BA],
IRB [auth CA],
IS [auth AA],
ISA [auth BA],
ISB [auth CA],
IT [auth AA],
ITA [auth BA],
ITB [auth CA],
IU [auth AA],
IUA [auth BA],
IUB [auth CA],
IV [auth AA],
IVA [auth BD],
IVB [auth CA],
IW [auth AA],
IWA [auth CA],
IWB [auth CE],
IX [auth AA],
IXA [auth CA],
IY [auth AA],
IYA [auth CA],
IYB [auth DA],
IZ [auth AA],
IZA [auth CA],
IZB [auth DA],
JAA [auth AA],
JAB [auth CA],
JAC [auth DA],
JBA [auth AA],
JBB [auth CA],
JBC [auth DA],
JCA [auth AA],
JCB [auth CA],
JCC [auth DA],
JDA [auth AA],
JDB [auth CA],
JDC [auth DA],
JE [auth AA],
JEA [auth AA],
JEB [auth CA],
JEC [auth DT],
JF [auth AA],
JFA [auth AA],
JFB [auth CA],
JG [auth AA],
JGA [auth AA],
JGB [auth CA],
JH [auth AA],
JHA [auth AA],
JHB [auth CA],
JI [auth AA],
JIA [auth AA],
JIB [auth CA],
JJ [auth AA],
JJA [auth AA],
JJB [auth CA],
JK [auth AA],
JKA [auth AB],
JKB [auth CA],
JL [auth AA],
JLA [auth AN],
JLB [auth CA],
JM [auth AA],
JMA [auth A0],
JMB [auth CA],
JN [auth AA],
JNA [auth BA],
JNB [auth CA],
JO [auth AA],
JOA [auth BA],
JOB [auth CA],
JP [auth AA],
JPA [auth BA],
JPB [auth CA],
JQ [auth AA],
JQA [auth BA],
JQB [auth CA],
JR [auth AA],
JRA [auth BA],
JRB [auth CA],
JS [auth AA],
JSA [auth BA],
JSB [auth CA],
JT [auth AA],
JTA [auth BA],
JTB [auth CA],
JU [auth AA],
JUA [auth BA],
JUB [auth CA],
JV [auth AA],
JVA [auth BE],
JVB [auth CA],
JW [auth AA],
JWA [auth CA],
JWB [auth CF],
JX [auth AA],
JXA [auth CA],
JXB [auth C7],
JY [auth AA],
JYA [auth CA],
JYB [auth DA],
JZ [auth AA],
JZA [auth CA],
JZB [auth DA],
KAA [auth AA],
KAB [auth CA],
KAC [auth DA],
KBA [auth AA],
KBB [auth CA],
KBC [auth DA],
KCA [auth AA],
KCB [auth CA],
KCC [auth DA],
KDA [auth AA],
KDB [auth CA],
KDC [auth DA],
KE [auth AA],
KEA [auth AA],
KEB [auth CA],
KEC [auth DW],
KF [auth AA],
KFA [auth AA],
KFB [auth CA],
KG [auth AA],
KGA [auth AA],
KGB [auth CA],
KH [auth AA],
KHA [auth AA],
KHB [auth CA],
KI [auth AA],
KIA [auth AA],
KIB [auth CA],
KJ [auth AA],
KJA [auth AA],
KJB [auth CA],
KK [auth AA],
KKA [auth AB],
KKB [auth CA],
KL [auth AA],
KLA [auth AN],
KLB [auth CA],
KM [auth AA],
KMA [auth A0],
KMB [auth CA],
KN [auth AA],
KNA [auth BA],
KNB [auth CA],
KO [auth AA],
KOA [auth BA],
KOB [auth CA],
KP [auth AA],
KPA [auth BA],
KPB [auth CA],
KQ [auth AA],
KQA [auth BA],
KQB [auth CA],
KR [auth AA],
KRA [auth BA],
KRB [auth CA],
KS [auth AA],
KSA [auth BA],
KSB [auth CA],
KT [auth AA],
KTA [auth BA],
KTB [auth CA],
KU [auth AA],
KUA [auth BA],
KUB [auth CA],
KV [auth AA],
KVA [auth BF],
KVB [auth CA],
KW [auth AA],
KWA [auth CA],
KWB [auth CF],
KX [auth AA],
KXA [auth CA],
KXB [auth C8],
KY [auth AA],
KYA [auth CA],
KYB [auth DA],
KZ [auth AA],
KZA [auth CA],
KZB [auth DA],
LAA [auth AA],
LAB [auth CA],
LAC [auth DA],
LBA [auth AA],
LBB [auth CA],
LBC [auth DA],
LCA [auth AA],
LCB [auth CA],
LCC [auth DA],
LDA [auth AA],
LDB [auth CA],
LDC [auth DA],
LE [auth AA],
LEA [auth AA],
LEB [auth CA],
LEC [auth DW],
LF [auth AA],
LFA [auth AA],
LFB [auth CA],
LG [auth AA],
LGA [auth AA],
LGB [auth CA],
LH [auth AA],
LHA [auth AA],
LHB [auth CA],
LI [auth AA],
LIA [auth AA],
LIB [auth CA],
LJ [auth AA],
LJA [auth AA],
LJB [auth CA],
LK [auth AA],
LKA [auth AD],
LKB [auth CA],
LL [auth AA],
LLA [auth AN],
LLB [auth CA],
LM [auth AA],
LMA [auth A0],
LMB [auth CA],
LN [auth AA],
LNA [auth BA],
LNB [auth CA],
LO [auth AA],
LOA [auth BA],
LOB [auth CA],
LP [auth AA],
LPA [auth BA],
LPB [auth CA],
LQ [auth AA],
LQA [auth BA],
LQB [auth CA],
LR [auth AA],
LRA [auth BA],
LRB [auth CA],
LS [auth AA],
LSA [auth BA],
LSB [auth CA],
LT [auth AA],
LTA [auth BA],
LTB [auth CA],
LU [auth AA],
LUA [auth BA],
LUB [auth CA],
LV [auth AA],
LVA [auth BK],
LVB [auth CA],
LW [auth AA],
LWA [auth CA],
LWB [auth CF],
LX [auth AA],
LXA [auth CA],
LY [auth AA],
LYA [auth CA],
LYB [auth DA],
LZ [auth AA],
LZA [auth CA],
LZB [auth DA],
MAA [auth AA],
MAB [auth CA],
MAC [auth DA],
MBA [auth AA],
MBB [auth CA],
MBC [auth DA],
MCA [auth AA],
MCB [auth CA],
MCC [auth DA],
MDA [auth AA],
MDB [auth CA],
MDC [auth DA],
ME [auth AA],
MEA [auth AA],
MEB [auth CA],
MEC [auth DW],
MF [auth AA],
MFA [auth AA],
MFB [auth CA],
MG [auth AA],
MGA [auth AA],
MGB [auth CA],
MH [auth AA],
MHA [auth AA],
MHB [auth CA],
MI [auth AA],
MIA [auth AA],
MIB [auth CA],
MJ [auth AA],
MJA [auth AA],
MJB [auth CA],
MK [auth AA],
MKA [auth AD],
MKB [auth CA],
ML [auth AA],
MLA [auth AO],
MLB [auth CA],
MM [auth AA],
MMA [auth A0],
MMB [auth CA],
MN [auth AA],
MNA [auth BA],
MNB [auth CA],
MO [auth AA],
MOA [auth BA],
MOB [auth CA],
MP [auth AA],
MPA [auth BA],
MPB [auth CA],
MQ [auth AA],
MQA [auth BA],
MQB [auth CA],
MR [auth AA],
MRA [auth BA],
MRB [auth CA],
MS [auth AA],
MSA [auth BA],
MSB [auth CA],
MT [auth AA],
MTA [auth BA],
MTB [auth CA],
MU [auth AA],
MUA [auth BA],
MUB [auth CA],
MV [auth AA],
MVA [auth BL],
MVB [auth CA],
MW [auth AA],
MWA [auth CA],
MWB [auth CF],
MX [auth AA],
MXA [auth CA],
MXB [auth DA],
MY [auth AA],
MYA [auth CA],
MYB [auth DA],
MZ [auth AA],
MZA [auth CA],
MZB [auth DA],
NAA [auth AA],
NAB [auth CA],
NAC [auth DA],
NBA [auth AA],
NBB [auth CA],
NBC [auth DA],
NCA [auth AA],
NCB [auth CA],
NCC [auth DA],
NDA [auth AA],
NDB [auth CA],
NDC [auth DA],
NE [auth AA],
NEA [auth AA],
NEB [auth CA],
NEC [auth DZ],
NF [auth AA],
NFA [auth AA],
NFB [auth CA],
NG [auth AA],
NGA [auth AA],
NGB [auth CA],
NH [auth AA],
NHA [auth AA],
NHB [auth CA],
NI [auth AA],
NIA [auth AA],
NIB [auth CA],
NJ [auth AA],
NJA [auth AA],
NJB [auth CA],
NK [auth AA],
NKA [auth AD],
NKB [auth CA],
NL [auth AA],
NLA [auth AP],
NLB [auth CA],
NM [auth AA],
NMA [auth A0],
NMB [auth CA],
NN [auth AA],
NNA [auth BA],
NNB [auth CA],
NO [auth AA],
NOA [auth BA],
NOB [auth CA],
NP [auth AA],
NPA [auth BA],
NPB [auth CA],
NQ [auth AA],
NQA [auth BA],
NQB [auth CA],
NR [auth AA],
NRA [auth BA],
NRB [auth CA],
NS [auth AA],
NSA [auth BA],
NSB [auth CA],
NT [auth AA],
NTA [auth BA],
NTB [auth CA],
NU [auth AA],
NUA [auth BA],
NUB [auth CA],
NV [auth AA],
NVA [auth BL],
NVB [auth CB],
NW [auth AA],
NWA [auth CA],
NWB [auth CG],
NX [auth AA],
NXA [auth CA],
NXB [auth DA],
NY [auth AA],
NYA [auth CA],
NYB [auth DA],
NZ [auth AA],
NZA [auth CA],
NZB [auth DA],
OAA [auth AA],
OAB [auth CA],
OAC [auth DA],
OBA [auth AA],
OBB [auth CA],
OBC [auth DA],
OCA [auth AA],
OCB [auth CA],
OCC [auth DA],
OD [auth AA],
ODA [auth AA],
ODB [auth CA],
ODC [auth DA],
OE [auth AA],
OEA [auth AA],
OEB [auth CA],
OEC [auth DZ],
OF [auth AA],
OFA [auth AA],
OFB [auth CA],
OG [auth AA],
OGA [auth AA],
OGB [auth CA],
OH [auth AA],
OHA [auth AA],
OHB [auth CA],
OI [auth AA],
OIA [auth AA],
OIB [auth CA],
OJ [auth AA],
OJA [auth AB],
OJB [auth CA],
OK [auth AA],
OKA [auth AD],
OKB [auth CA],
OL [auth AA],
OLA [auth AP],
OLB [auth CA],
OM [auth AA],
OMA [auth A2],
OMB [auth CA],
ON [auth AA],
ONA [auth BA],
ONB [auth CA],
OO [auth AA],
OOA [auth BA],
OOB [auth CA],
OP [auth AA],
OPA [auth BA],
OPB [auth CA],
OQ [auth AA],
OQA [auth BA],
OQB [auth CA],
OR [auth AA],
ORA [auth BA],
ORB [auth CA],
OS [auth AA],
OSA [auth BA],
OSB [auth CA],
OT [auth AA],
OTA [auth BA],
OTB [auth CA],
OU [auth AA],
OUA [auth BA],
OUB [auth CA],
OV [auth AA],
OVA [auth BM],
OVB [auth CB],
OW [auth AA],
OWA [auth CA],
OWB [auth CN],
OX [auth AA],
OXA [auth CA],
OXB [auth DA],
OY [auth AA],
OYA [auth CA],
OYB [auth DA],
OZ [auth AA],
OZA [auth CA],
OZB [auth DA],
PAA [auth AA],
PAB [auth CA],
PAC [auth DA],
PBA [auth AA],
PBB [auth CA],
PBC [auth DA],
PCA [auth AA],
PCB [auth CA],
PCC [auth DA],
PD [auth AA],
PDA [auth AA],
PDB [auth CA],
PDC [auth DA],
PE [auth AA],
PEA [auth AA],
PEB [auth CA],
PF [auth AA],
PFA [auth AA],
PFB [auth CA],
PG [auth AA],
PGA [auth AA],
PGB [auth CA],
PH [auth AA],
PHA [auth AA],
PHB [auth CA],
PI [auth AA],
PIA [auth AA],
PIB [auth CA],
PJ [auth AA],
PJA [auth AB],
PJB [auth CA],
PK [auth AA],
PKA [auth AD],
PKB [auth CA],
PL [auth AA],
PLA [auth AP],
PLB [auth CA],
PM [auth AA],
PMB [auth CA],
PN [auth AA],
PNA [auth BA],
PNB [auth CA],
PO [auth AA],
POA [auth BA],
POB [auth CA],
PP [auth AA],
PPA [auth BA],
PPB [auth CA],
PQ [auth AA],
PQA [auth BA],
PQB [auth CA],
PR [auth AA],
PRA [auth BA],
PRB [auth CA],
PS [auth AA],
PSA [auth BA],
PSB [auth CA],
PT [auth AA],
PTA [auth BA],
PTB [auth CA],
PU [auth AA],
PUA [auth BA],
PUB [auth CA],
PV [auth AA],
PVB [auth CB],
PW [auth AA],
PWA [auth CA],
PWB [auth CO],
PX [auth AA],
PXA [auth CA],
PXB [auth DA],
PY [auth AA],
PYA [auth CA],
PYB [auth DA],
PZ [auth AA],
PZA [auth CA],
PZB [auth DA],
QAA [auth AA],
QAB [auth CA],
QAC [auth DA],
QBA [auth AA],
QBB [auth CA],
QBC [auth DA],
QCA [auth AA],
QCB [auth CA],
QCC [auth DA],
QD [auth AA],
QDA [auth AA],
QDB [auth CA],
QDC [auth DA],
QE [auth AA],
QEA [auth AA],
QEB [auth CA],
QF [auth AA],
QFA [auth AA],
QFB [auth CA],
QG [auth AA],
QGA [auth AA],
QGB [auth CA],
QH [auth AA],
QHA [auth AA],
QHB [auth CA],
QI [auth AA],
QIA [auth AA],
QIB [auth CA],
QJ [auth AA],
QJA [auth AB],
QJB [auth CA],
QK [auth AA],
QKA [auth AD],
QKB [auth CA],
QL [auth AA],
QLA [auth AQ],
QLB [auth CA],
QM [auth AA],
QMB [auth CA],
QN [auth AA],
QNA [auth BA],
QNB [auth CA],
QO [auth AA],
QOA [auth BA],
QOB [auth CA],
QP [auth AA],
QPA [auth BA],
QPB [auth CA],
QQ [auth AA],
QQA [auth BA],
QQB [auth CA],
QR [auth AA],
QRA [auth BA],
QRB [auth CA],
QS [auth AA],
QSA [auth BA],
QSB [auth CA],
QT [auth AA],
QTA [auth BA],
QTB [auth CA],
QU [auth AA],
QUA [auth BA],
QUB [auth CA],
QV [auth AA],
QVA [auth BN],
QVB [auth CB],
QW [auth AA],
QWA [auth CA],
QWB [auth CP],
QX [auth AA],
QXA [auth CA],
QXB [auth DA],
QY [auth AA],
QYA [auth CA],
QYB [auth DA],
QZ [auth AA],
QZA [auth CA],
QZB [auth DA],
RAA [auth AA],
RAB [auth CA],
RAC [auth DA],
RBA [auth AA],
RBB [auth CA],
RBC [auth DA],
RCA [auth AA],
RCB [auth CA],
RCC [auth DA],
RD [auth AA],
RDA [auth AA],
RDB [auth CA],
RDC [auth DA],
RE [auth AA],
REA [auth AA],
REB [auth CA],
RF [auth AA],
RFA [auth AA],
RFB [auth CA],
RG [auth AA],
RGA [auth AA],
RGB [auth CA],
RH [auth AA],
RHA [auth AA],
RHB [auth CA],
RI [auth AA],
RIA [auth AA],
RIB [auth CA],
RJ [auth AA],
RJA [auth AB],
RJB [auth CA],
RK [auth AA],
RKA [auth AD],
RKB [auth CA],
RL [auth AA],
RLA [auth AQ],
RLB [auth CA],
RM [auth AA],
RMA [auth A5],
RMB [auth CA],
RN [auth AA],
RNA [auth BA],
RNB [auth CA],
RO [auth AA],
ROA [auth BA],
ROB [auth CA],
RP [auth AA],
RPA [auth BA],
RPB [auth CA],
RQ [auth AA],
RQA [auth BA],
RQB [auth CA],
RR [auth AA],
RRA [auth BA],
RRB [auth CA],
RS [auth AA],
RSA [auth BA],
RSB [auth CA],
RT [auth AA],
RTA [auth BA],
RTB [auth CA],
RU [auth AA],
RUA [auth BA],
RUB [auth CA],
RV [auth AA],
RVA [auth BN],
RVB [auth CB],
RW [auth AA],
RWA [auth CA],
RWB [auth CQ],
RX [auth AA],
RXA [auth CA],
RXB [auth DA],
RY [auth AA],
RYA [auth CA],
RYB [auth DA],
RZ [auth AA],
RZA [auth CA],
RZB [auth DA],
SAA [auth AA],
SAB [auth CA],
SAC [auth DA],
SBA [auth AA],
SBB [auth CA],
SBC [auth DA],
SCA [auth AA],
SCB [auth CA],
SCC [auth DA],
SD [auth AA],
SDA [auth AA],
SDB [auth CA],
SDC [auth DA],
SE [auth AA],
SEA [auth AA],
SEB [auth CA],
SF [auth AA],
SFA [auth AA],
SFB [auth CA],
SG [auth AA],
SGA [auth AA],
SGB [auth CA],
SH [auth AA],
SHA [auth AA],
SHB [auth CA],
SI [auth AA],
SIA [auth AA],
SIB [auth CA],
SJ [auth AA],
SJA [auth AB],
SJB [auth CA],
SK [auth AA],
SKA [auth AD],
SKB [auth CA],
SL [auth AA],
SLA [auth AQ],
SLB [auth CA],
SM [auth AA],
SMA [auth A6],
SMB [auth CA],
SN [auth AA],
SNA [auth BA],
SNB [auth CA],
SO [auth AA],
SOA [auth BA],
SOB [auth CA],
SP [auth AA],
SPA [auth BA],
SPB [auth CA],
SQ [auth AA],
SQA [auth BA],
SQB [auth CA],
SR [auth AA],
SRA [auth BA],
SRB [auth CA],
SS [auth AA],
SSA [auth BA],
SSB [auth CA],
ST [auth AA],
STA [auth BA],
STB [auth CA],
SU [auth AA],
SUA [auth BA],
SUB [auth CA],
SV [auth AA],
SVA [auth BS],
SVB [auth CB],
SW [auth AA],
SWA [auth CA],
SWB [auth CQ],
SX [auth AA],
SXA [auth CA],
SXB [auth DA],
SY [auth AA],
SYA [auth CA],
SYB [auth DA],
SZ [auth AA],
SZA [auth CA],
SZB [auth DA],
TAA [auth AA],
TAB [auth CA],
TAC [auth DA],
TBA [auth AA],
TBB [auth CA],
TBC [auth DA],
TCA [auth AA],
TCB [auth CA],
TCC [auth DA],
TD [auth AA],
TDA [auth AA],
TDB [auth CA],
TDC [auth DA],
TE [auth AA],
TEA [auth AA],
TEB [auth CA],
TF [auth AA],
TFA [auth AA],
TFB [auth CA],
TG [auth AA],
TGA [auth AA],
TGB [auth CA],
TH [auth AA],
THA [auth AA],
THB [auth CA],
TI [auth AA],
TIA [auth AA],
TIB [auth CA],
TJ [auth AA],
TJA [auth AB],
TJB [auth CA],
TK [auth AA],
TKA [auth AD],
TKB [auth CA],
TL [auth AA],
TLA [auth AQ],
TLB [auth CA],
TM [auth AA],
TMB [auth CA],
TN [auth AA],
TNA [auth BA],
TNB [auth CA],
TO [auth AA],
TOA [auth BA],
TOB [auth CA],
TP [auth AA],
TPA [auth BA],
TPB [auth CA],
TQ [auth AA],
TQA [auth BA],
TQB [auth CA],
TR [auth AA],
TRA [auth BA],
TRB [auth CA],
TS [auth AA],
TSA [auth BA],
TSB [auth CA],
TT [auth AA],
TTA [auth BA],
TTB [auth CA],
TU [auth AA],
TUA [auth BA],
TUB [auth CA],
TV [auth AA],
TVA [auth BT],
TVB [auth CB],
TW [auth AA],
TWA [auth CA],
TWB [auth CQ],
TX [auth AA],
TXA [auth CA],
TXB [auth DA],
TY [auth AA],
TYA [auth CA],
TYB [auth DA],
TZ [auth AA],
TZA [auth CA],
TZB [auth DA],
UAA [auth AA],
UAB [auth CA],
UAC [auth DA],
UBA [auth AA],
UBB [auth CA],
UBC [auth DA],
UCA [auth AA],
UCB [auth CA],
UCC [auth DA],
UD [auth AA],
UDA [auth AA],
UDB [auth CA],
UDC [auth DA],
UE [auth AA],
UEA [auth AA],
UEB [auth CA],
UF [auth AA],
UFA [auth AA],
UFB [auth CA],
UG [auth AA],
UGA [auth AA],
UGB [auth CA],
UH [auth AA],
UHA [auth AA],
UHB [auth CA],
UI [auth AA],
UIA [auth AA],
UIB [auth CA],
UJ [auth AA],
UJA [auth AB],
UJB [auth CA],
UK [auth AA],
UKA [auth AD],
UKB [auth CA],
UL [auth AA],
ULA [auth AR],
ULB [auth CA],
UM [auth AA],
UMA [auth A6],
UMB [auth CA],
UN [auth AA],
UNA [auth BA],
UNB [auth CA],
UO [auth AA],
UOA [auth BA],
UOB [auth CA],
UP [auth AA],
UPA [auth BA],
UPB [auth CA],
UQ [auth AA],
UQA [auth BA],
UQB [auth CA],
UR [auth AA],
URA [auth BA],
URB [auth CA],
US [auth AA],
USA [auth BA],
USB [auth CA],
UT [auth AA],
UTA [auth BA],
UTB [auth CA],
UU [auth AA],
UUA [auth BA],
UUB [auth CA],
UV [auth AA],
UVA [auth BW],
UVB [auth CB],
UW [auth AA],
UWA [auth CA],
UWB [auth CQ],
UX [auth AA],
UXA [auth CA],
UXB [auth DA],
UY [auth AA],
UYA [auth CA],
UYB [auth DA],
UZ [auth AA],
UZA [auth CA],
UZB [auth DA],
VAA [auth AA],
VAB [auth CA],
VAC [auth DA],
VBA [auth AA],
VBB [auth CA],
VBC [auth DA],
VCA [auth AA],
VCB [auth CA],
VCC [auth DA],
VD [auth AA],
VDA [auth AA],
VDB [auth CA],
VDC [auth DA],
VE [auth AA],
VEA [auth AA],
VEB [auth CA],
VF [auth AA],
VFA [auth AA],
VFB [auth CA],
VG [auth AA],
VGA [auth AA],
VGB [auth CA],
VH [auth AA],
VHA [auth AA],
VHB [auth CA],
VI [auth AA],
VIA [auth AA],
VIB [auth CA],
VJ [auth AA],
VJA [auth AB],
VJB [auth CA],
VK [auth AA],
VKA [auth AE],
VKB [auth CA],
VL [auth AA],
VLA [auth AU],
VLB [auth CA],
VM [auth AA],
VMA [auth A7],
VMB [auth CA],
VN [auth AA],
VNA [auth BA],
VNB [auth CA],
VO [auth AA],
VOA [auth BA],
VOB [auth CA],
VP [auth AA],
VPA [auth BA],
VPB [auth CA],
VQ [auth AA],
VQA [auth BA],
VQB [auth CA],
VR [auth AA],
VRA [auth BA],
VRB [auth CA],
VS [auth AA],
VSA [auth BA],
VSB [auth CA],
VT [auth AA],
VTA [auth BA],
VTB [auth CA],
VU [auth AA],
VUA [auth BA],
VUB [auth CA],
VV [auth AA],
VVA [auth BW],
VVB [auth CB],
VW [auth AA],
VWA [auth CA],
VWB [auth CR],
VX [auth AA],
VXA [auth CA],
VXB [auth DA],
VY [auth AA],
VYA [auth CA],
VYB [auth DA],
VZ [auth AA],
VZA [auth CA],
VZB [auth DA],
WAA [auth AA],
WAB [auth CA],
WAC [auth DA],
WBA [auth AA],
WBB [auth CA],
WBC [auth DA],
WCA [auth AA],
WCB [auth CA],
WCC [auth DA],
WD [auth AA],
WDA [auth AA],
WDB [auth CA],
WDC [auth DA],
WE [auth AA],
WEA [auth AA],
WEB [auth CA],
WF [auth AA],
WFA [auth AA],
WFB [auth CA],
WG [auth AA],
WGA [auth AA],
WGB [auth CA],
WH [auth AA],
WHA [auth AA],
WHB [auth CA],
WI [auth AA],
WIA [auth AA],
WIB [auth CA],
WJ [auth AA],
WJA [auth AB],
WJB [auth CA],
WK [auth AA],
WKA [auth AE],
WKB [auth CA],
WL [auth AA],
WLA [auth AU],
WLB [auth CA],
WM [auth AA],
WMA [auth A8],
WMB [auth CA],
WN [auth AA],
WNA [auth BA],
WNB [auth CA],
WO [auth AA],
WOA [auth BA],
WOB [auth CA],
WP [auth AA],
WPA [auth BA],
WPB [auth CA],
WQ [auth AA],
WQA [auth BA],
WQB [auth CA],
WR [auth AA],
WRA [auth BA],
WRB [auth CA],
WS [auth AA],
WSA [auth BA],
WSB [auth CA],
WT [auth AA],
WTA [auth BA],
WTB [auth CA],
WU [auth AA],
WUA [auth BA],
WUB [auth CA],
WV [auth AA],
WVA [auth BW],
WVB [auth CB],
WW [auth AA],
WWA [auth CA],
WWB [auth CU],
WX [auth AA],
WXA [auth CA],
WXB [auth DA],
WY [auth AA],
WYA [auth CA],
WYB [auth DA],
WZ [auth AA],
WZA [auth CA],
WZB [auth DA],
XAA [auth AA],
XAB [auth CA],
XAC [auth DA],
XBA [auth AA],
XBB [auth CA],
XBC [auth DA],
XCA [auth AA],
XCB [auth CA],
XCC [auth DA],
XD [auth AA],
XDA [auth AA],
XDB [auth CA],
XDC [auth DA],
XE [auth AA],
XEA [auth AA],
XEB [auth CA],
XF [auth AA],
XFA [auth AA],
XFB [auth CA],
XG [auth AA],
XGA [auth AA],
XGB [auth CA],
XH [auth AA],
XHA [auth AA],
XHB [auth CA],
XI [auth AA],
XIA [auth AA],
XIB [auth CA],
XJ [auth AA],
XJA [auth AB],
XJB [auth CA],
XK [auth AA],
XKA [auth AE],
XKB [auth CA],
XL [auth AA],
XLA [auth AU],
XLB [auth CA],
XM [auth AA],
XMB [auth CA],
XN [auth AA],
XNA [auth BA],
XNB [auth CA],
XO [auth AA],
XOA [auth BA],
XOB [auth CA],
XP [auth AA],
XPA [auth BA],
XPB [auth CA],
XQ [auth AA],
XQA [auth BA],
XQB [auth CA],
XR [auth AA],
XRA [auth BA],
XRB [auth CA],
XS [auth AA],
XSA [auth BA],
XSB [auth CA],
XT [auth AA],
XTA [auth BA],
XTB [auth CA],
XU [auth AA],
XUA [auth BA],
XUB [auth CA],
XV [auth AA],
XVA [auth BZ],
XVB [auth CB],
XW [auth AA],
XWA [auth CA],
XWB [auth CV],
XX [auth AA],
XXA [auth CA],
XXB [auth DA],
XY [auth AA],
XYA [auth CA],
XYB [auth DA],
XZ [auth AA],
XZA [auth CA],
XZB [auth DA],
YAA [auth AA],
YAB [auth CA],
YAC [auth DA],
YBA [auth AA],
YBB [auth CA],
YBC [auth DA],
YCA [auth AA],
YCB [auth CA],
YCC [auth DA],
YD [auth AA],
YDA [auth AA],
YDB [auth CA],
YDC [auth DA],
YE [auth AA],
YEA [auth AA],
YEB [auth CA],
YF [auth AA],
YFA [auth AA],
YFB [auth CA],
YG [auth AA],
YGA [auth AA],
YGB [auth CA],
YH [auth AA],
YHA [auth AA],
YHB [auth CA],
YI [auth AA],
YIA [auth AA],
YIB [auth CA],
YJ [auth AA],
YJA [auth AB],
YJB [auth CA],
YK [auth AA],
YKA [auth AE],
YKB [auth CA],
YL [auth AA],
YLA [auth AU],
YLB [auth CA],
YM [auth AA],
YMA [auth A9],
YMB [auth CA],
YN [auth AA],
YNA [auth BA],
YNB [auth CA],
YO [auth AA],
YOA [auth BA],
YOB [auth CA],
YP [auth AA],
YPA [auth BA],
YPB [auth CA],
YQ [auth AA],
YQA [auth BA],
YQB [auth CA],
YR [auth AA],
YRA [auth BA],
YRB [auth CA],
YS [auth AA],
YSA [auth BA],
YSB [auth CA],
YT [auth AA],
YTA [auth BA],
YTB [auth CA],
YU [auth AA],
YUA [auth BA],
YUB [auth CA],
YV [auth AA],
YVB [auth CB],
YW [auth AA],
YWA [auth CA],
YWB [auth CV],
YX [auth AA],
YXA [auth CA],
YXB [auth DA],
YY [auth AA],
YYA [auth CA],
YYB [auth DA],
YZ [auth AA],
YZA [auth CA],
YZB [auth DA],
ZAA [auth AA],
ZAB [auth CA],
ZAC [auth DA],
ZBA [auth AA],
ZBB [auth CA],
ZBC [auth DA],
ZCA [auth AA],
ZCB [auth CA],
ZCC [auth DA],
ZD [auth AA],
ZDA [auth AA],
ZDB [auth CA],
ZDC [auth DA],
ZE [auth AA],
ZEA [auth AA],
ZEB [auth CA],
ZF [auth AA],
ZFA [auth AA],
ZFB [auth CA],
ZG [auth AA],
ZGA [auth AA],
ZGB [auth CA],
ZH [auth AA],
ZHA [auth AA],
ZHB [auth CA],
ZI [auth AA],
ZIA [auth AA],
ZIB [auth CA],
ZJ [auth AA],
ZJA [auth AB],
ZJB [auth CA],
ZK [auth AA],
ZKA [auth AE],
ZKB [auth CA],
ZL [auth AA],
ZLA [auth AU],
ZLB [auth CA],
ZM [auth AA],
ZMA [auth BA],
ZMB [auth CA],
ZN [auth AA],
ZNA [auth BA],
ZNB [auth CA],
ZO [auth AA],
ZOA [auth BA],
ZOB [auth CA],
ZP [auth AA],
ZPA [auth BA],
ZPB [auth CA],
ZQ [auth AA],
ZQA [auth BA],
ZQB [auth CA],
ZR [auth AA],
ZRA [auth BA],
ZRB [auth CA],
ZS [auth AA],
ZSA [auth BA],
ZSB [auth CA],
ZT [auth AA],
ZTA [auth BA],
ZTB [auth CA],
ZU [auth AA],
ZUA [auth BA],
ZUB [auth CA],
ZV [auth AA],
ZVA [auth CA],
ZVB [auth CB],
ZW [auth AA],
ZWA [auth CA],
ZWB [auth CW],
ZX [auth AA],
ZXA [auth CA],
ZXB [auth DA],
ZY [auth AA],
ZYA [auth CA],
ZYB [auth DA],
ZZ [auth AA],
ZZA [auth CA],
ZZB [auth DA]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Modified Residues  3 Unique
IDChains TypeFormula2D DiagramParent
2QZ
Query on 2QZ
GB [auth BX],
ND [auth DX]
L-PEPTIDE LINKINGC6 H13 N O3THR
2R3
Query on 2R3
GB [auth BX],
ND [auth DX]
L-PEPTIDE LINKINGC10 H13 N O4TYR
MVA
Query on MVA
GB [auth BX],
ND [auth DX]
L-PEPTIDE LINKINGC6 H13 N O2VAL
Biologically Interesting Molecules (External Reference) 1 Unique
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.80 Å
  • R-Value Free: 0.264 
  • R-Value Work: 0.209 
  • R-Value Observed: 0.212 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 209.84α = 90
b = 450.58β = 90
c = 623.43γ = 90
Software Package:
Software NamePurpose
PHENIXrefinement
PHASERphasing
PDB_EXTRACTdata extraction
XDSdata reduction
XSCALEdata scaling
PHASERphasing

Structure Validation

View Full Validation Report



Ligand Structure Quality Assessment 


Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2015-01-28
    Type: Initial release
  • Version 1.1: 2015-11-04
    Changes: Data collection
  • Version 1.2: 2016-05-04
    Changes: Structure summary
  • Version 2.0: 2019-07-03
    Changes: Data collection, Derived calculations, Non-polymer description, Structure summary
  • Version 2.1: 2019-07-10
    Changes: Advisory, Data collection, Derived calculations
  • Version 2.2: 2023-12-27
    Changes: Data collection, Database references, Derived calculations