Download MendeleyCrystal structure of E47Q mutant cytidine deaminase from Mycobacterium tuberculosis (MtCDA E47Q)
Sanchez-Quitian, A.Z., Rodrigues-Junior, V., Rehm, J.G., Eichler, P., Trivella, D.B.B., Bizarro, C.V., Basso, L.A., Santos, D.S.(2015) RSC Adv
4WIF
Crystal structure of E47Q mutant cytidine deaminase from Mycobacterium tuberculosis (MtCDA E47Q)
- PDB DOI: https://doi.org/10.2210/pdb4WIF/pdb
- Classification: HYDROLASE
- Organism(s): Mycobacterium tuberculosis
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2014-09-25 Released: 2015-09-09
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.249
- R-Value Work: 0.214
- R-Value Observed: 0.215
wwPDB Validation 3D Report Full Report
This is version 2.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Cytidine deaminase | 133 | Mycobacterium tuberculosis | Mutation(s): 1 EC: 3.5.4.5 |  | |
UniProt | |||||
Find proteins for P9WPH3 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)) Explore P9WPH3 Go to UniProtKB: P9WPH3 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P9WPH3 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ZN Query on ZN | C [auth A], D [auth B] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.249
- R-Value Work: 0.214
- R-Value Observed: 0.215
- Space Group: C 2 2 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 65.59 | α = 90 |
| b = 77.84 | β = 90 |
| c = 111.62 | γ = 90 |
| Software Name | Purpose |
|---|---|
| SCALA | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
Entry History
Deposition Data
- Released Date: 2015-09-09 Deposition Author(s): Trivella, D.B., Sanchez-Quitian, A.Z., Basso, L.A., Santos, D.S.
Revision History (Full details and data files)
- Version 1.0: 2015-09-09
Type: Initial release - Version 2.0: 2023-12-27
Changes: Atomic model, Data collection, Database references, Derived calculations
