4V9R

Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome


Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.00 Å
  • R-Value Free: 0.259 
  • R-Value Work: 0.203 
  • R-Value Observed: 0.206 

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Literature

The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.

Bulkley, D.Brandi, L.Polikanov, Y.S.Fabbretti, A.O'Connor, M.Gualerzi, C.O.Steitz, T.A.

(2014) Cell Rep 6: 357-365

  • DOI: https://doi.org/10.1016/j.celrep.2013.12.024
  • Primary Citation of Related Structures:  
    4V9R, 4V9S

  • PubMed Abstract: 

    The translocation of mRNA and tRNA through the ribosome is catalyzed by elongation factor G (EF-G), a universally conserved guanosine triphosphate hydrolase (GTPase). The mechanism by which the closely related decapeptide antibiotics dityromycin and GE82832 inhibit EF-G-catalyzed translocation is elucidated in this study. Using crystallographic and biochemical experiments, we demonstrate that these antibiotics bind to ribosomal protein S12 in solution alone as well as within the small ribosomal subunit, inducing long-range effects on the ribosomal head. The crystal structure of the antibiotic in complex with the 70S ribosome reveals that the binding involves conserved amino acid residues of S12 whose mutations result in in vitro and in vivo antibiotic resistance and loss of antibiotic binding. The data also suggest that GE82832/dityromycin inhibits EF-G-catalyzed translocation by disrupting a critical contact between EF-G and S12 that is required to stabilize the posttranslocational conformation of EF-G, thereby preventing the ribosome-EF-G complex from entering a conformation productive for translocation.


  • Organizational Affiliation

    Department of Chemistry, Yale University, New Haven, CT 06511, USA.


Macromolecules

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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S2B [auth AB],
EB [auth CB]
256Thermus thermophilusMutation(s): 0 
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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S3C [auth AC],
FB [auth CC]
239Thermus thermophilusMutation(s): 0 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S4D [auth AD],
GB [auth CD]
209Thermus thermophilusMutation(s): 0 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S5E [auth AE],
HB [auth CE]
162Thermus thermophilusMutation(s): 0 
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S6F [auth AF],
IB [auth CF]
101Thermus thermophilusMutation(s): 0 
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S7G [auth AG],
JB [auth CG]
156Thermus thermophilusMutation(s): 0 
UniProt
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S8H [auth AH],
KB [auth CH]
138Thermus thermophilusMutation(s): 0 
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S9I [auth AI],
LB [auth CI]
128Thermus thermophilusMutation(s): 0 
UniProt
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S10J [auth AJ],
MB [auth CJ]
105Thermus thermophilusMutation(s): 0 
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S11K [auth AK],
NB [auth CK]
129Thermus thermophilusMutation(s): 0 
UniProt
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S12L [auth AL],
OB [auth CL]
132Thermus thermophilusMutation(s): 0 
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S13M [auth AM],
PB [auth CM]
126Thermus thermophilusMutation(s): 0 
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S14N [auth AN],
QB [auth CN]
61Thermus thermophilusMutation(s): 0 
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S15O [auth AO],
RB [auth CO]
89Thermus thermophilusMutation(s): 0 
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S16P [auth AP],
SB [auth CP]
88Thermus thermophilusMutation(s): 0 
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S17Q [auth AQ],
TB [auth CQ]
105Thermus thermophilusMutation(s): 0 
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S18R [auth AR],
UB [auth CR]
88Thermus thermophilusMutation(s): 0 
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S19S [auth AS],
VB [auth CS]
93Thermus thermophilusMutation(s): 0 
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein S20T [auth AT],
WB [auth CT]
106Thermus thermophilusMutation(s): 0 
UniProt
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
30S Ribosomal Protein THXU [auth AU],
XB [auth CU]
27Thermus thermophilusMutation(s): 0 
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Entity ID: 24
MoleculeChains Sequence LengthOrganismDetailsImage
DityromycinAC [auth CW],
X [auth AW]
10Streptomyces sp.Mutation(s): 0 
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Entity ID: 27
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L2AA [auth BD],
DC [auth DD]
276Thermus thermophilusMutation(s): 0 
UniProt
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Entity ID: 28
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L3BA [auth BE],
EC [auth DE]
206Thermus thermophilusMutation(s): 0 
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L4CA [auth BF],
FC [auth DF]
210Thermus thermophilusMutation(s): 0 
UniProt
Find proteins for Q5SHN9 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L5DA [auth BG],
GC [auth DG]
182Thermus thermophilusMutation(s): 0 
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Entity ID: 31
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L6EA [auth BH],
HC [auth DH]
180Thermus thermophilusMutation(s): 0 
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Entity ID: 32
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L9FA [auth BI],
IC [auth DI]
148Thermus thermophilusMutation(s): 0 
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L13GA [auth BN],
JC [auth DN]
140Thermus thermophilusMutation(s): 0 
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Entity ID: 34
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L14HA [auth BO],
KC [auth DO]
122Thermus thermophilusMutation(s): 0 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L15IA [auth BP],
LC [auth DP]
150Thermus thermophilusMutation(s): 0 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L16JA [auth BQ],
MC [auth DQ]
141Thermus thermophilusMutation(s): 0 
UniProt
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L17KA [auth BR],
NC [auth DR]
118Thermus thermophilusMutation(s): 0 
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L18LA [auth BS],
OC [auth DS]
112Thermus thermophilusMutation(s): 0 
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L19MA [auth BT],
PC [auth DT]
146Thermus thermophilusMutation(s): 0 
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L20NA [auth BU],
QC [auth DU]
118Thermus thermophilusMutation(s): 0 
UniProt
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L21OA [auth BV],
RC [auth DV]
101Thermus thermophilusMutation(s): 0 
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L22PA [auth BW],
SC [auth DW]
113Thermus thermophilusMutation(s): 0 
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L23QA [auth BX],
TC [auth DX]
96Thermus thermophilusMutation(s): 0 
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L24RA [auth BY],
UC [auth DY]
110Thermus thermophilusMutation(s): 0 
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L25SA [auth BZ],
VC [auth DZ]
206Thermus thermophilusMutation(s): 0 
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Entity ID: 46
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L27TA [auth B0],
WC [auth D0]
85Thermus thermophilusMutation(s): 0 
UniProt
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L28UA [auth B1],
XC [auth D1]
98Thermus thermophilusMutation(s): 0 
UniProt
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L29VA [auth B2],
YC [auth D2]
72Thermus thermophilusMutation(s): 0 
UniProt
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L30WA [auth B3],
ZC [auth D3]
60Thermus thermophilusMutation(s): 0 
UniProt
Find proteins for Q5SHQ6 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupQ5SHQ6
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L31AD [auth D4],
XA [auth B4]
71Thermus thermophilusMutation(s): 0 
UniProt
Find proteins for Q5SJE1 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupQ5SJE1
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L32BD [auth D5],
YA [auth B5]
60Thermus thermophilusMutation(s): 0 
UniProt
Find proteins for P80339 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP80339
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Entity ID: 52
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L33CD [auth D6],
ZA [auth B6]
54Thermus thermophilusMutation(s): 0 
UniProt
Find proteins for P35871 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP35871
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Entity ID: 53
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L34AB [auth B7],
DD [auth D7]
49Thermus thermophilusMutation(s): 0 
UniProt
Find proteins for P80340 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP80340
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Entity ID: 54
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L35BB [auth B8],
ED [auth D8]
65Thermus thermophilusMutation(s): 0 
UniProt
Find proteins for Q5SKU1 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ5SKU1
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Entity ID: 55
MoleculeChains Sequence LengthOrganismDetailsImage
50S Ribosomal Protein L36CB [auth B9],
FD [auth D9]
37Thermus thermophilusMutation(s): 0 
UniProt
Find proteins for P80256 (Thermus thermophilus)
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Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP80256
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Entity ID: 1
MoleculeChains LengthOrganismImage
16S Ribosomal RNAA [auth AA],
DB [auth CA]
1,522Thermus thermophilus
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Entity ID: 22
MoleculeChains LengthOrganismImage
mRNAV [auth AV],
YB [auth CV]
24N/A
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Entity ID: 23
MoleculeChains LengthOrganismImage
P-site tRNAW [auth AX],
ZB [auth CX]
77Escherichia coli
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Entity ID: 25
MoleculeChains LengthOrganismImage
23S Ribosomal RNABC [auth DA],
Y [auth BA]
2,915Thermus thermophilus
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Entity ID: 26
MoleculeChains LengthOrganismImage
5S Ribosomal RNACC [auth DB],
Z [auth BB]
122Thermus thermophilus
Sequence Annotations
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Small Molecules
Ligands 5 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
SF4
Query on SF4

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UL [auth AD],
ZZA [auth CD]
IRON/SULFUR CLUSTER
Fe4 S4
LJBDFODJNLIPKO-UHFFFAOYSA-N
FME
Query on FME

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FM [auth AX],
GAB [auth CX]
N-FORMYLMETHIONINE
C6 H11 N O3 S
PYUSHNKNPOHWEZ-YFKPBYRVSA-N
ZN
Query on ZN

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ATA [auth B6]
CM [auth AN]
DAB [auth CN]
HTA [auth B9]
JSA [auth BY]
ATA [auth B6],
CM [auth AN],
DAB [auth CN],
HTA [auth B9],
JSA [auth BY],
LBC [auth DY],
OBC [auth D4],
RBC [auth D5],
SBC [auth D6],
UBC [auth D9],
XSA [auth B4],
YSA [auth B5]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
K
Query on K

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GY [auth BA],
JJB [auth DA]
POTASSIUM ION
K
NPYPAHLBTDXSSS-UHFFFAOYSA-N
MG
Query on MG

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AAA [auth BA]
AAB [auth CE]
AAC [auth DB]
ABA [auth BA]
ABB [auth DA]
AAA [auth BA],
AAB [auth CE],
AAC [auth DB],
ABA [auth BA],
ABB [auth DA],
ABC [auth DQ],
ACA [auth BA],
ACB [auth DA],
ADA [auth BA],
ADB [auth DA],
AE [auth AA],
AEA [auth BA],
AEB [auth DA],
AF [auth AA],
AFA [auth BA],
AFB [auth DA],
AG [auth AA],
AGA [auth BA],
AGB [auth DA],
AH [auth AA],
AHA [auth BA],
AHB [auth DA],
AI [auth AA],
AIA [auth BA],
AIB [auth DA],
AJ [auth AA],
AJA [auth BA],
AJB [auth DA],
AK [auth AA],
AKA [auth BA],
AKB [auth DA],
AL [auth AA],
ALA [auth BA],
ALB [auth DA],
AM,
AMA [auth BA],
AMB [auth DA],
AN [auth BA],
ANA [auth BA],
ANB [auth DA],
AO [auth BA],
AOA [auth BA],
AOB [auth DA],
AP [auth BA],
APA [auth BA],
APB [auth DA],
AQ [auth BA],
AQA [auth BD],
AQB [auth DA],
AR [auth BA],
ARA [auth BN],
ARB [auth DA],
AS [auth BA],
ASA [auth BV],
ASB [auth DA],
AT [auth BA],
ATB [auth DA],
AU [auth BA],
AUA [auth CA],
AUB [auth DA],
AV [auth BA],
AVA [auth CA],
AVB [auth DA],
AW [auth BA],
AWA [auth CA],
AWB [auth DA],
AX [auth BA],
AXA [auth CA],
AXB [auth DA],
AY [auth BA],
AYA [auth CA],
AYB [auth DA],
AZ [auth BA],
AZA [auth CA],
AZB [auth DA],
BAA [auth BA],
BAB [auth CE],
BAC [auth DB],
BBA [auth BA],
BBB [auth DA],
BBC [auth DQ],
BCA [auth BA],
BCB [auth DA],
BDA [auth BA],
BDB [auth DA],
BE [auth AA],
BEA [auth BA],
BEB [auth DA],
BF [auth AA],
BFA [auth BA],
BFB [auth DA],
BG [auth AA],
BGA [auth BA],
BGB [auth DA],
BH [auth AA],
BHA [auth BA],
BHB [auth DA],
BI [auth AA],
BIA [auth BA],
BIB [auth DA],
BJ [auth AA],
BJA [auth BA],
BJB [auth DA],
BK [auth AA],
BKA [auth BA],
BKB [auth DA],
BL [auth AA],
BLA [auth BA],
BLB [auth DA],
BM [auth AN],
BMA [auth BA],
BMB [auth DA],
BN [auth BA],
BNA [auth BA],
BNB [auth DA],
BO [auth BA],
BOA [auth BA],
BOB [auth DA],
BP [auth BA],
BPA [auth BB],
BPB [auth DA],
BQ [auth BA],
BQA [auth BD],
BQB [auth DA],
BR [auth BA],
BRA [auth BN],
BRB [auth DA],
BS [auth BA],
BSA [auth BV],
BSB [auth DA],
BT [auth BA],
BTA [auth B7],
BTB [auth DA],
BU [auth BA],
BUA [auth CA],
BUB [auth DA],
BV [auth BA],
BVA [auth CA],
BVB [auth DA],
BW [auth BA],
BWA [auth CA],
BWB [auth DA],
BX [auth BA],
BXA [auth CA],
BXB [auth DA],
BY [auth BA],
BYA [auth CA],
BYB [auth DA],
BZ [auth BA],
BZA [auth CA],
BZB [auth DA],
CAA [auth BA],
CAB [auth CF],
CAC [auth DB],
CBA [auth BA],
CBB [auth DA],
CBC [auth DQ],
CCA [auth BA],
CCB [auth DA],
CDA [auth BA],
CDB [auth DA],
CE [auth AA],
CEA [auth BA],
CEB [auth DA],
CF [auth AA],
CFA [auth BA],
CFB [auth DA],
CG [auth AA],
CGA [auth BA],
CGB [auth DA],
CH [auth AA],
CHA [auth BA],
CHB [auth DA],
CI [auth AA],
CIA [auth BA],
CIB [auth DA],
CJ [auth AA],
CJA [auth BA],
CJB [auth DA],
CK [auth AA],
CKA [auth BA],
CKB [auth DA],
CL [auth AA],
CLA [auth BA],
CLB [auth DA],
CMA [auth BA],
CMB [auth DA],
CN [auth BA],
CNA [auth BA],
CNB [auth DA],
CO [auth BA],
COA [auth BA],
COB [auth DA],
CP [auth BA],
CPA [auth BB],
CPB [auth DA],
CQ [auth BA],
CQA [auth BD],
CQB [auth DA],
CR [auth BA],
CRA [auth BN],
CRB [auth DA],
CS [auth BA],
CSA [auth BW],
CSB [auth DA],
CT [auth BA],
CTA [auth B7],
CTB [auth DA],
CU [auth BA],
CUA [auth CA],
CUB [auth DA],
CV [auth BA],
CVA [auth CA],
CVB [auth DA],
CW [auth BA],
CWA [auth CA],
CWB [auth DA],
CX [auth BA],
CXA [auth CA],
CXB [auth DA],
CY [auth BA],
CYA [auth CA],
CYB [auth DA],
CZ [auth BA],
CZA [auth CA],
CZB [auth DA],
DAA [auth BA],
DAC [auth DB],
DBA [auth BA],
DBB [auth DA],
DBC [auth DR],
DCA [auth BA],
DCB [auth DA],
DDA [auth BA],
DDB [auth DA],
DE [auth AA],
DEA [auth BA],
DEB [auth DA],
DF [auth AA],
DFA [auth BA],
DFB [auth DA],
DG [auth AA],
DGA [auth BA],
DGB [auth DA],
DH [auth AA],
DHA [auth BA],
DHB [auth DA],
DI [auth AA],
DIA [auth BA],
DIB [auth DA],
DJ [auth AA],
DJA [auth BA],
DJB [auth DA],
DK [auth AA],
DKA [auth BA],
DKB [auth DA],
DL [auth AA],
DLA [auth BA],
DLB [auth DA],
DM [auth AS],
DMA [auth BA],
DMB [auth DA],
DN [auth BA],
DNA [auth BA],
DNB [auth DA],
DO [auth BA],
DOA [auth BA],
DOB [auth DA],
DP [auth BA],
DPA [auth BB],
DPB [auth DA],
DQ [auth BA],
DQA [auth BD],
DQB [auth DA],
DR [auth BA],
DRA [auth BN],
DRB [auth DA],
DS [auth BA],
DSA [auth BW],
DSB [auth DA],
DT [auth BA],
DTA [auth B7],
DTB [auth DA],
DU [auth BA],
DUA [auth CA],
DUB [auth DA],
DV [auth BA],
DVA [auth CA],
DVB [auth DA],
DW [auth BA],
DWA [auth CA],
DWB [auth DA],
DX [auth BA],
DXA [auth CA],
DXB [auth DA],
DY [auth BA],
DYA [auth CA],
DYB [auth DA],
DZ [auth BA],
DZA [auth CA],
DZB [auth DA],
EAA [auth BA],
EAB [auth CN],
EAC [auth DD],
EBA [auth BA],
EBB [auth DA],
EBC [auth DU],
ECA [auth BA],
ECB [auth DA],
EDA [auth BA],
EDB [auth DA],
EE [auth AA],
EEA [auth BA],
EEB [auth DA],
EF [auth AA],
EFA [auth BA],
EFB [auth DA],
EG [auth AA],
EGA [auth BA],
EGB [auth DA],
EH [auth AA],
EHA [auth BA],
EHB [auth DA],
EI [auth AA],
EIA [auth BA],
EIB [auth DA],
EJ [auth AA],
EJA [auth BA],
EJB [auth DA],
EK [auth AA],
EKA [auth BA],
EKB [auth DA],
EL [auth AA],
ELA [auth BA],
ELB [auth DA],
EM [auth AV],
EMA [auth BA],
EMB [auth DA],
EN [auth BA],
ENA [auth BA],
ENB [auth DA],
EO [auth BA],
EOA [auth BA],
EOB [auth DA],
EP [auth BA],
EPA [auth BB],
EPB [auth DA],
EQ [auth BA],
EQA [auth BD],
EQB [auth DA],
ER [auth BA],
ERA [auth BO],
ERB [auth DA],
ES [auth BA],
ESA [auth BW],
ESB [auth DA],
ET [auth BA],
ETA [auth B7],
ETB [auth DA],
EU [auth BA],
EUA [auth CA],
EUB [auth DA],
EV [auth BA],
EVA [auth CA],
EVB [auth DA],
EW [auth BA],
EWA [auth CA],
EWB [auth DA],
EX [auth BA],
EXA [auth CA],
EXB [auth DA],
EY [auth BA],
EYA [auth CA],
EYB [auth DA],
EZ [auth BA],
EZA [auth CA],
EZB [auth DA],
FAA [auth BA],
FAB [auth CT],
FAC [auth DD],
FBA [auth BA],
FBB [auth DA],
FBC [auth DU],
FCA [auth BA],
FCB [auth DA],
FDA [auth BA],
FDB [auth DA],
FE [auth AA],
FEA [auth BA],
FEB [auth DA],
FF [auth AA],
FFA [auth BA],
FFB [auth DA],
FG [auth AA],
FGA [auth BA],
FGB [auth DA],
FH [auth AA],
FHA [auth BA],
FHB [auth DA],
FI [auth AA],
FIA [auth BA],
FIB [auth DA],
FJ [auth AA],
FJA [auth BA],
FJB [auth DA],
FK [auth AA],
FKA [auth BA],
FKB [auth DA],
FL [auth AA],
FLA [auth BA],
FLB [auth DA],
FMA [auth BA],
FMB [auth DA],
FN [auth BA],
FNA [auth BA],
FNB [auth DA],
FO [auth BA],
FOA [auth BA],
FOB [auth DA],
FP [auth BA],
FPA [auth BB],
FPB [auth DA],
FQ [auth BA],
FQA [auth BE],
FQB [auth DA],
FR [auth BA],
FRA [auth BP],
FRB [auth DA],
FS [auth BA],
FSA [auth BW],
FSB [auth DA],
FT [auth BA],
FTA [auth B8],
FTB [auth DA],
FU [auth BA],
FUA [auth CA],
FUB [auth DA],
FV [auth BA],
FVA [auth CA],
FVB [auth DA],
FW [auth BA],
FWA [auth CA],
FWB [auth DA],
FX [auth BA],
FXA [auth CA],
FXB [auth DA],
FY [auth BA],
FYA [auth CA],
FYB [auth DA],
FZ [auth BA],
FZA [auth CA],
FZB [auth DA],
GAA [auth BA],
GAC [auth DD],
GBA [auth BA],
GBB [auth DA],
GBC [auth DV],
GCA [auth BA],
GCB [auth DA],
GD [auth AA],
GDA [auth BA],
GDB [auth DA],
GE [auth AA],
GEA [auth BA],
GEB [auth DA],
GF [auth AA],
GFA [auth BA],
GFB [auth DA],
GG [auth AA],
GGA [auth BA],
GGB [auth DA],
GH [auth AA],
GHA [auth BA],
GHB [auth DA],
GI [auth AA],
GIA [auth BA],
GIB [auth DA],
GJ [auth AA],
GJA [auth BA],
GJB [auth DA],
GK [auth AA],
GKA [auth BA],
GKB [auth DA],
GL [auth AA],
GLA [auth BA],
GLB [auth DA],
GM [auth AX],
GMA [auth BA],
GMB [auth DA],
GN [auth BA],
GNA [auth BA],
GNB [auth DA],
GO [auth BA],
GOA [auth BA],
GOB [auth DA],
GP [auth BA],
GPA [auth BB],
GPB [auth DA],
GQ [auth BA],
GQA [auth BE],
GQB [auth DA],
GR [auth BA],
GRA [auth BP],
GRB [auth DA],
GS [auth BA],
GSA [auth BW],
GSB [auth DA],
GT [auth BA],
GTA [auth B8],
GTB [auth DA],
GU [auth BA],
GUA [auth CA],
GUB [auth DA],
GV [auth BA],
GVA [auth CA],
GVB [auth DA],
GW [auth BA],
GWA [auth CA],
GWB [auth DA],
GX [auth BA],
GXA [auth CA],
GXB [auth DA],
GYA [auth CA],
GYB [auth DA],
GZ [auth BA],
GZA [auth CA],
GZB [auth DA],
HAA [auth BA],
HAB [auth CX],
HAC [auth DD],
HBA [auth BA],
HBB [auth DA],
HBC [auth DV],
HCA [auth BA],
HCB [auth DA],
HD [auth AA],
HDA [auth BA],
HDB [auth DA],
HE [auth AA],
HEA [auth BA],
HEB [auth DA],
HF [auth AA],
HFA [auth BA],
HFB [auth DA],
HG [auth AA],
HGA [auth BA],
HGB [auth DA],
HH [auth AA],
HHA [auth BA],
HHB [auth DA],
HI [auth AA],
HIA [auth BA],
HIB [auth DA],
HJ [auth AA],
HJA [auth BA],
HJB [auth DA],
HK [auth AA],
HKA [auth BA],
HKB [auth DA],
HL [auth AA],
HLA [auth BA],
HLB [auth DA],
HM [auth AX],
HMA [auth BA],
HMB [auth DA],
HN [auth BA],
HNA [auth BA],
HNB [auth DA],
HO [auth BA],
HOA [auth BA],
HOB [auth DA],
HP [auth BA],
HPA [auth BB],
HPB [auth DA],
HQ [auth BA],
HQA [auth BE],
HQB [auth DA],
HR [auth BA],
HRA [auth BP],
HRB [auth DA],
HS [auth BA],
HSA [auth BX],
HSB [auth DA],
HT [auth BA],
HTB [auth DA],
HU [auth BA],
HUA [auth CA],
HUB [auth DA],
HV [auth BA],
HVA [auth CA],
HVB [auth DA],
HW [auth BA],
HWA [auth CA],
HWB [auth DA],
HX [auth BA],
HXA [auth CA],
HXB [auth DA],
HY [auth BA],
HYA [auth CA],
HYB [auth DA],
HZ [auth BA],
HZA [auth CA],
HZB [auth DA],
IAA [auth BA],
IAB [auth CX],
IAC [auth DD],
IBA [auth BA],
IBB [auth DA],
IBC [auth DV],
ICA [auth BA],
ICB [auth DA],
ID [auth AA],
IDA [auth BA],
IDB [auth DA],
IE [auth AA],
IEA [auth BA],
IEB [auth DA],
IF [auth AA],
IFA [auth BA],
IFB [auth DA],
IG [auth AA],
IGA [auth BA],
IGB [auth DA],
IH [auth AA],
IHA [auth BA],
IHB [auth DA],
II [auth AA],
IIA [auth BA],
IIB [auth DA],
IJ [auth AA],
IJA [auth BA],
IJB [auth DA],
IK [auth AA],
IKA [auth BA],
IKB [auth DA],
IL [auth AA],
ILA [auth BA],
ILB [auth DA],
IM [auth AX],
IMA [auth BA],
IMB [auth DA],
IN [auth BA],
INA [auth BA],
INB [auth DA],
IO [auth BA],
IOA [auth BA],
IOB [auth DA],
IP [auth BA],
IPA [auth BB],
IPB [auth DA],
IQ [auth BA],
IQA [auth BE],
IQB [auth DA],
IR [auth BA],
IRA [auth BP],
IRB [auth DA],
IS [auth BA],
ISA [auth BX],
ISB [auth DA],
IT [auth BA],
ITA [auth B9],
ITB [auth DA],
IU [auth BA],
IUA [auth CA],
IUB [auth DA],
IV [auth BA],
IVA [auth CA],
IVB [auth DA],
IW [auth BA],
IWA [auth CA],
IWB [auth DA],
IX [auth BA],
IXA [auth CA],
IXB [auth DA],
IY [auth BA],
IYA [auth CA],
IYB [auth DA],
IZ [auth BA],
IZA [auth CA],
IZB [auth DA],
JAA [auth BA],
JAB [auth CX],
JAC [auth DE],
JBA [auth BA],
JBB [auth DA],
JBC [auth DW],
JCA [auth BA],
JCB [auth DA],
JD [auth AA],
JDA [auth BA],
JDB [auth DA],
JE [auth AA],
JEA [auth BA],
JEB [auth DA],
JF [auth AA],
JFA [auth BA],
JFB [auth DA],
JG [auth AA],
JGA [auth BA],
JGB [auth DA],
JH [auth AA],
JHA [auth BA],
JHB [auth DA],
JI [auth AA],
JIA [auth BA],
JIB [auth DA],
JJ [auth AA],
JJA [auth BA],
JK [auth AA],
JKA [auth BA],
JKB [auth DA],
JL [auth AA],
JLA [auth BA],
JLB [auth DA],
JM [auth AX],
JMA [auth BA],
JMB [auth DA],
JN [auth BA],
JNA [auth BA],
JNB [auth DA],
JO [auth BA],
JOA [auth BA],
JOB [auth DA],
JP [auth BA],
JPA [auth BB],
JPB [auth DA],
JQ [auth BA],
JQA [auth BE],
JQB [auth DA],
JR [auth BA],
JRA [auth BQ],
JRB [auth DA],
JS [auth BA],
JSB [auth DA],
JT [auth BA],
JTA [auth CA],
JTB [auth DA],
JU [auth BA],
JUA [auth CA],
JUB [auth DA],
JV [auth BA],
JVA [auth CA],
JVB [auth DA],
JW [auth BA],
JWA [auth CA],
JWB [auth DA],
JX [auth BA],
JXA [auth CA],
JXB [auth DA],
JY [auth BA],
JYA [auth CA],
JYB [auth DA],
JZ [auth BA],
JZA [auth CA],
JZB [auth DA],
KAA [auth BA],
KAB [auth DA],
KAC [auth DE],
KBA [auth BA],
KBB [auth DA],
KBC [auth DW],
KCA [auth BA],
KCB [auth DA],
KD [auth AA],
KDA [auth BA],
KDB [auth DA],
KE [auth AA],
KEA [auth BA],
KEB [auth DA],
KF [auth AA],
KFA [auth BA],
KFB [auth DA],
KG [auth AA],
KGA [auth BA],
KGB [auth DA],
KH [auth AA],
KHA [auth BA],
KHB [auth DA],
KI [auth AA],
KIA [auth BA],
KIB [auth DA],
KJ [auth AA],
KJA [auth BA],
KJB [auth DA],
KK [auth AA],
KKA [auth BA],
KKB [auth DA],
KL [auth AA],
KLA [auth BA],
KLB [auth DA],
KM [auth AX],
KMA [auth BA],
KMB [auth DA],
KN [auth BA],
KNA [auth BA],
KNB [auth DA],
KO [auth BA],
KOA [auth BA],
KOB [auth DA],
KP [auth BA],
KPA [auth BB],
KPB [auth DA],
KQ [auth BA],
KQA [auth BE],
KQB [auth DA],
KR [auth BA],
KRA [auth BQ],
KRB [auth DA],
KS [auth BA],
KSA [auth BZ],
KSB [auth DA],
KT [auth BA],
KTA [auth CA],
KTB [auth DA],
KU [auth BA],
KUA [auth CA],
KUB [auth DA],
KV [auth BA],
KVA [auth CA],
KVB [auth DA],
KW [auth BA],
KWA [auth CA],
KWB [auth DA],
KX [auth BA],
KXA [auth CA],
KXB [auth DA],
KY [auth BA],
KYA [auth CA],
KYB [auth DA],
KZ [auth BA],
KZA [auth CA],
KZB [auth DA],
LAA [auth BA],
LAB [auth DA],
LAC [auth DE],
LBA [auth BA],
LBB [auth DA],
LCA [auth BA],
LCB [auth DA],
LD [auth AA],
LDA [auth BA],
LDB [auth DA],
LE [auth AA],
LEA [auth BA],
LEB [auth DA],
LF [auth AA],
LFA [auth BA],
LFB [auth DA],
LG [auth AA],
LGA [auth BA],
LGB [auth DA],
LH [auth AA],
LHA [auth BA],
LHB [auth DA],
LI [auth AA],
LIA [auth BA],
LIB [auth DA],
LJ [auth AA],
LJA [auth BA],
LJB [auth DA],
LK [auth AA],
LKA [auth BA],
LKB [auth DA],
LL [auth AA],
LLA [auth BA],
LLB [auth DA],
LM [auth AX],
LMA [auth BA],
LMB [auth DA],
LN [auth BA],
LNA [auth BA],
LNB [auth DA],
LO [auth BA],
LOA [auth BA],
LOB [auth DA],
LP [auth BA],
LPA [auth BB],
LPB [auth DA],
LQ [auth BA],
LQA [auth BE],
LQB [auth DA],
LR [auth BA],
LRA [auth BQ],
LRB [auth DA],
LS [auth BA],
LSA [auth B0],
LSB [auth DA],
LT [auth BA],
LTA [auth CA],
LTB [auth DA],
LU [auth BA],
LUA [auth CA],
LUB [auth DA],
LV [auth BA],
LVA [auth CA],
LVB [auth DA],
LW [auth BA],
LWA [auth CA],
LWB [auth DA],
LX [auth BA],
LXA [auth CA],
LXB [auth DA],
LY [auth BA],
LYA [auth CA],
LYB [auth DA],
LZ [auth BA],
LZA [auth CA],
LZB [auth DA],
MAA [auth BA],
MAB [auth DA],
MAC [auth DE],
MBA [auth BA],
MBB [auth DA],
MBC [auth DY],
MCA [auth BA],
MCB [auth DA],
MD [auth AA],
MDA [auth BA],
MDB [auth DA],
ME [auth AA],
MEA [auth BA],
MEB [auth DA],
MF [auth AA],
MFA [auth BA],
MFB [auth DA],
MG [auth AA],
MGA [auth BA],
MGB [auth DA],
MH [auth AA],
MHA [auth BA],
MHB [auth DA],
MI [auth AA],
MIA [auth BA],
MIB [auth DA],
MJ [auth AA],
MJA [auth BA],
MJB [auth DA],
MK [auth AA],
MKA [auth BA],
MKB [auth DA],
ML [auth AA],
MLA [auth BA],
MLB [auth DA],
MM [auth AX],
MMA [auth BA],
MMB [auth DA],
MN [auth BA],
MNA [auth BA],
MNB [auth DA],
MO [auth BA],
MOA [auth BA],
MOB [auth DA],
MP [auth BA],
MPA [auth BB],
MPB [auth DA],
MQ [auth BA],
MQA [auth BE],
MQB [auth DA],
MR [auth BA],
MRA [auth BQ],
MRB [auth DA],
MS [auth BA],
MSA [auth B0],
MSB [auth DA],
MT [auth BA],
MTA [auth CA],
MTB [auth DA],
MU [auth BA],
MUA [auth CA],
MUB [auth DA],
MV [auth BA],
MVA [auth CA],
MVB [auth DA],
MW [auth BA],
MWA [auth CA],
MWB [auth DA],
MX [auth BA],
MXA [auth CA],
MXB [auth DA],
MY [auth BA],
MYA [auth CA],
MYB [auth DA],
MZ [auth BA],
MZA [auth CA],
MZB [auth DA],
NAA [auth BA],
NAB [auth DA],
NAC [auth DE],
NBA [auth BA],
NBB [auth DA],
NBC [auth D3],
NCA [auth BA],
NCB [auth DA],
ND [auth AA],
NDA [auth BA],
NDB [auth DA],
NE [auth AA],
NEA [auth BA],
NEB [auth DA],
NF [auth AA],
NFA [auth BA],
NFB [auth DA],
NG [auth AA],
NGA [auth BA],
NGB [auth DA],
NH [auth AA],
NHA [auth BA],
NHB [auth DA],
NI [auth AA],
NIA [auth BA],
NIB [auth DA],
NJ [auth AA],
NJA [auth BA],
NJB [auth DA],
NK [auth AA],
NKA [auth BA],
NKB [auth DA],
NL [auth AA],
NLA [auth BA],
NLB [auth DA],
NM [auth AX],
NMA [auth BA],
NMB [auth DA],
NN [auth BA],
NNA [auth BA],
NNB [auth DA],
NO [auth BA],
NOA [auth BA],
NOB [auth DA],
NP [auth BA],
NPA [auth BB],
NPB [auth DA],
NQ [auth BA],
NQA [auth BE],
NQB [auth DA],
NR [auth BA],
NRA [auth BR],
NRB [auth DA],
NS [auth BA],
NSA [auth B0],
NSB [auth DA],
NT [auth BA],
NTA [auth CA],
NTB [auth DA],
NU [auth BA],
NUA [auth CA],
NUB [auth DA],
NV [auth BA],
NVA [auth CA],
NVB [auth DA],
NW [auth BA],
NWA [auth CA],
NWB [auth DA],
NX [auth BA],
NXA [auth CA],
NXB [auth DA],
NY [auth BA],
NYA [auth CA],
NYB [auth DA],
NZ [auth BA],
NZA [auth CA],
NZB [auth DA],
OAA [auth BA],
OAB [auth DA],
OAC [auth DE],
OBA [auth BA],
OBB [auth DA],
OCA [auth BA],
OCB [auth DA],
OD [auth AA],
ODA [auth BA],
ODB [auth DA],
OE [auth AA],
OEA [auth BA],
OEB [auth DA],
OF [auth AA],
OFA [auth BA],
OFB [auth DA],
OG [auth AA],
OGA [auth BA],
OGB [auth DA],
OH [auth AA],
OHA [auth BA],
OHB [auth DA],
OI [auth AA],
OIA [auth BA],
OIB [auth DA],
OJ [auth AA],
OJA [auth BA],
OJB [auth DA],
OK [auth AA],
OKA [auth BA],
OKB [auth DA],
OL [auth AA],
OLA [auth BA],
OLB [auth DA],
OM [auth AX],
OMA [auth BA],
OMB [auth DA],
ON [auth BA],
ONA [auth BA],
ONB [auth DA],
OO [auth BA],
OOA [auth BA],
OOB [auth DA],
OP [auth BA],
OPA [auth BB],
OPB [auth DA],
OQ [auth BA],
OQA [auth BF],
OQB [auth DA],
OR [auth BA],
ORA [auth BR],
ORB [auth DA],
OS [auth BA],
OSA [auth B0],
OSB [auth DA],
OT [auth BA],
OTA [auth CA],
OTB [auth DA],
OU [auth BA],
OUA [auth CA],
OUB [auth DA],
OV [auth BA],
OVA [auth CA],
OVB [auth DA],
OW [auth BA],
OWA [auth CA],
OWB [auth DA],
OX [auth BA],
OXA [auth CA],
OXB [auth DA],
OY [auth BA],
OYA [auth CA],
OYB [auth DA],
OZ [auth BA],
OZA [auth CA],
OZB [auth DA],
PAA [auth BA],
PAB [auth DA],
PAC [auth DF],
PBA [auth BA],
PBB [auth DA],
PBC [auth D5],
PCA [auth BA],
PCB [auth DA],
PD [auth AA],
PDA [auth BA],
PDB [auth DA],
PE [auth AA],
PEA [auth BA],
PEB [auth DA],
PF [auth AA],
PFA [auth BA],
PFB [auth DA],
PG [auth AA],
PGA [auth BA],
PGB [auth DA],
PH [auth AA],
PHA [auth BA],
PHB [auth DA],
PI [auth AA],
PIA [auth BA],
PIB [auth DA],
PJ [auth AA],
PJA [auth BA],
PJB [auth DA],
PK [auth AA],
PKA [auth BA],
PKB [auth DA],
PL [auth AA],
PLA [auth BA],
PLB [auth DA],
PM [auth BA],
PMA [auth BA],
PMB [auth DA],
PN [auth BA],
PNA [auth BA],
PNB [auth DA],
PO [auth BA],
POA [auth BA],
POB [auth DA],
PP [auth BA],
PPA [auth BB],
PPB [auth DA],
PQ [auth BA],
PQA [auth BF],
PQB [auth DA],
PR [auth BA],
PRA [auth BR],
PRB [auth DA],
PS [auth BA],
PSA [auth B0],
PSB [auth DA],
PT [auth BA],
PTA [auth CA],
PTB [auth DA],
PU [auth BA],
PUA [auth CA],
PUB [auth DA],
PV [auth BA],
PVA [auth CA],
PVB [auth DA],
PW [auth BA],
PWA [auth CA],
PWB [auth DA],
PX [auth BA],
PXA [auth CA],
PXB [auth DA],
PY [auth BA],
PYA [auth CA],
PYB [auth DA],
PZ [auth BA],
PZA [auth CA],
PZB [auth DA],
QAA [auth BA],
QAB [auth DA],
QAC [auth DF],
QBA [auth BA],
QBB [auth DA],
QBC [auth D5],
QCA [auth BA],
QCB [auth DA],
QD [auth AA],
QDA [auth BA],
QDB [auth DA],
QE [auth AA],
QEA [auth BA],
QEB [auth DA],
QF [auth AA],
QFA [auth BA],
QFB [auth DA],
QG [auth AA],
QGA [auth BA],
QGB [auth DA],
QH [auth AA],
QHA [auth BA],
QHB [auth DA],
QI [auth AA],
QIA [auth BA],
QIB [auth DA],
QJ [auth AA],
QJA [auth BA],
QJB [auth DA],
QK [auth AA],
QKA [auth BA],
QKB [auth DA],
QL [auth AA],
QLA [auth BA],
QLB [auth DA],
QM [auth BA],
QMA [auth BA],
QMB [auth DA],
QN [auth BA],
QNA [auth BA],
QNB [auth DA],
QO [auth BA],
QOA [auth BA],
QOB [auth DA],
QP [auth BA],
QPA [auth BB],
QPB [auth DA],
QQ [auth BA],
QQA [auth BF],
QQB [auth DA],
QR [auth BA],
QRA [auth BU],
QRB [auth DA],
QS [auth BA],
QSA [auth B0],
QSB [auth DA],
QT [auth BA],
QTA [auth CA],
QTB [auth DA],
QU [auth BA],
QUA [auth CA],
QUB [auth DA],
QV [auth BA],
QVA [auth CA],
QVB [auth DA],
QW [auth BA],
QWA [auth CA],
QWB [auth DA],
QX [auth BA],
QXA [auth CA],
QXB [auth DA],
QY [auth BA],
QYA [auth CA],
QYB [auth DA],
QZ [auth BA],
QZA [auth CA],
QZB [auth DA],
RAA [auth BA],
RAB [auth DA],
RAC [auth DF],
RBA [auth BA],
RBB [auth DA],
RCA [auth BA],
RCB [auth DA],
RD [auth AA],
RDA [auth BA],
RDB [auth DA],
RE [auth AA],
REA [auth BA],
REB [auth DA],
RF [auth AA],
RFA [auth BA],
RFB [auth DA],
RG [auth AA],
RGA [auth BA],
RGB [auth DA],
RH [auth AA],
RHA [auth BA],
RHB [auth DA],
RI [auth AA],
RIA [auth BA],
RIB [auth DA],
RJ [auth AA],
RJA [auth BA],
RJB [auth DA],
RK [auth AA],
RKA [auth BA],
RKB [auth DA],
RL [auth AA],
RLA [auth BA],
RLB [auth DA],
RM [auth BA],
RMA [auth BA],
RMB [auth DA],
RN [auth BA],
RNA [auth BA],
RNB [auth DA],
RO [auth BA],
ROA [auth BA],
ROB [auth DA],
RP [auth BA],
RPA [auth BB],
RPB [auth DA],
RQ [auth BA],
RQA [auth BF],
RQB [auth DA],
RR [auth BA],
RRA [auth BU],
RRB [auth DA],
RS [auth BA],
RSA [auth B1],
RSB [auth DA],
RT [auth BA],
RTA [auth CA],
RTB [auth DA],
RU [auth BA],
RUA [auth CA],
RUB [auth DA],
RV [auth BA],
RVA [auth CA],
RVB [auth DA],
RW [auth BA],
RWA [auth CA],
RWB [auth DA],
RX [auth BA],
RXA [auth CA],
RXB [auth DA],
RY [auth BA],
RYA [auth CA],
RYB [auth DA],
RZ [auth BA],
RZA [auth CA],
RZB [auth DA],
SAA [auth BA],
SAB [auth DA],
SAC [auth DF],
SBA [auth BA],
SBB [auth DA],
SCA [auth BA],
SCB [auth DA],
SD [auth AA],
SDA [auth BA],
SDB [auth DA],
SE [auth AA],
SEA [auth BA],
SEB [auth DA],
SF [auth AA],
SFA [auth BA],
SFB [auth DA],
SG [auth AA],
SGA [auth BA],
SGB [auth DA],
SH [auth AA],
SHA [auth BA],
SHB [auth DA],
SI [auth AA],
SIA [auth BA],
SIB [auth DA],
SJ [auth AA],
SJA [auth BA],
SJB [auth DA],
SK [auth AA],
SKA [auth BA],
SKB [auth DA],
SL [auth AA],
SLA [auth BA],
SLB [auth DA],
SM [auth BA],
SMA [auth BA],
SMB [auth DA],
SN [auth BA],
SNA [auth BA],
SNB [auth DA],
SO [auth BA],
SOA [auth BA],
SOB [auth DA],
SP [auth BA],
SPA [auth BB],
SPB [auth DA],
SQ [auth BA],
SQA [auth BF],
SQB [auth DA],
SR [auth BA],
SRA [auth BU],
SRB [auth DA],
SS [auth BA],
SSA [auth B1],
SSB [auth DA],
ST [auth BA],
STA [auth CA],
STB [auth DA],
SU [auth BA],
SUA [auth CA],
SUB [auth DA],
SV [auth BA],
SVA [auth CA],
SVB [auth DA],
SW [auth BA],
SWA [auth CA],
SWB [auth DA],
SX [auth BA],
SXA [auth CA],
SXB [auth DA],
SY [auth BA],
SYA [auth CA],
SYB [auth DA],
SZ [auth BA],
SZA [auth CA],
SZB [auth DB],
TAA [auth BA],
TAB [auth DA],
TAC [auth DF],
TBA [auth BA],
TBB [auth DA],
TBC [auth D8],
TCA [auth BA],
TCB [auth DA],
TD [auth AA],
TDA [auth BA],
TDB [auth DA],
TE [auth AA],
TEA [auth BA],
TEB [auth DA],
TF [auth AA],
TFA [auth BA],
TFB [auth DA],
TG [auth AA],
TGA [auth BA],
TGB [auth DA],
TH [auth AA],
THA [auth BA],
THB [auth DA],
TI [auth AA],
TIA [auth BA],
TIB [auth DA],
TJ [auth AA],
TJA [auth BA],
TJB [auth DA],
TK [auth AA],
TKA [auth BA],
TKB [auth DA],
TL [auth AA],
TLA [auth BA],
TLB [auth DA],
TM [auth BA],
TMA [auth BA],
TMB [auth DA],
TN [auth BA],
TNA [auth BA],
TNB [auth DA],
TO [auth BA],
TOA [auth BA],
TOB [auth DA],
TP [auth BA],
TPA [auth BD],
TPB [auth DA],
TQ [auth BA],
TQA [auth BF],
TQB [auth DA],
TR [auth BA],
TRA [auth BU],
TRB [auth DA],
TS [auth BA],
TSA [auth B2],
TSB [auth DA],
TT [auth BA],
TTA [auth CA],
TTB [auth DA],
TU [auth BA],
TUA [auth CA],
TUB [auth DA],
TV [auth BA],
TVA [auth CA],
TVB [auth DA],
TW [auth BA],
TWA [auth CA],
TWB [auth DA],
TX [auth BA],
TXA [auth CA],
TXB [auth DA],
TY [auth BA],
TYA [auth CA],
TYB [auth DA],
TZ [auth BA],
TZA [auth CA],
TZB [auth DB],
UAA [auth BA],
UAB [auth DA],
UAC [auth DG],
UBA [auth BA],
UBB [auth DA],
UCA [auth BA],
UCB [auth DA],
UD [auth AA],
UDA [auth BA],
UDB [auth DA],
UE [auth AA],
UEA [auth BA],
UEB [auth DA],
UF [auth AA],
UFA [auth BA],
UFB [auth DA],
UG [auth AA],
UGA [auth BA],
UGB [auth DA],
UH [auth AA],
UHA [auth BA],
UHB [auth DA],
UI [auth AA],
UIA [auth BA],
UIB [auth DA],
UJ [auth AA],
UJA [auth BA],
UJB [auth DA],
UK [auth AA],
UKA [auth BA],
UKB [auth DA],
ULA [auth BA],
ULB [auth DA],
UM [auth BA],
UMA [auth BA],
UMB [auth DA],
UN [auth BA],
UNA [auth BA],
UNB [auth DA],
UO [auth BA],
UOA [auth BA],
UOB [auth DA],
UP [auth BA],
UPA [auth BD],
UPB [auth DA],
UQ [auth BA],
UQA [auth BG],
UQB [auth DA],
UR [auth BA],
URA [auth BU],
URB [auth DA],
US [auth BA],
USA [auth B3],
USB [auth DA],
UT [auth BA],
UTA [auth CA],
UTB [auth DA],
UU [auth BA],
UUA [auth CA],
UUB [auth DA],
UV [auth BA],
UVA [auth CA],
UVB [auth DA],
UW [auth BA],
UWA [auth CA],
UWB [auth DA],
UX [auth BA],
UXA [auth CA],
UXB [auth DA],
UY [auth BA],
UYA [auth CA],
UYB [auth DA],
UZ [auth BA],
UZA [auth CA],
UZB [auth DB],
VAA [auth BA],
VAB [auth DA],
VAC [auth DN],
VBA [auth BA],
VBB [auth DA],
VCA [auth BA],
VCB [auth DA],
VD [auth AA],
VDA [auth BA],
VDB [auth DA],
VE [auth AA],
VEA [auth BA],
VEB [auth DA],
VF [auth AA],
VFA [auth BA],
VFB [auth DA],
VG [auth AA],
VGA [auth BA],
VGB [auth DA],
VH [auth AA],
VHA [auth BA],
VHB [auth DA],
VI [auth AA],
VIA [auth BA],
VIB [auth DA],
VJ [auth AA],
VJA [auth BA],
VJB [auth DA],
VK [auth AA],
VKA [auth BA],
VKB [auth DA],
VL [auth AD],
VLA [auth BA],
VLB [auth DA],
VM [auth BA],
VMA [auth BA],
VMB [auth DA],
VN [auth BA],
VNA [auth BA],
VNB [auth DA],
VO [auth BA],
VOA [auth BA],
VOB [auth DA],
VP [auth BA],
VPA [auth BD],
VPB [auth DA],
VQ [auth BA],
VQA [auth BG],
VQB [auth DA],
VR [auth BA],
VRA [auth BU],
VRB [auth DA],
VS [auth BA],
VSA [auth B3],
VSB [auth DA],
VT [auth BA],
VTA [auth CA],
VTB [auth DA],
VU [auth BA],
VUA [auth CA],
VUB [auth DA],
VV [auth BA],
VVA [auth CA],
VVB [auth DA],
VW [auth BA],
VWA [auth CA],
VWB [auth DA],
VX [auth BA],
VXA [auth CA],
VXB [auth DA],
VY [auth BA],
VYA [auth CA],
VYB [auth DA],
VZ [auth BA],
VZA [auth CA],
VZB [auth DB],
WAA [auth BA],
WAB [auth DA],
WAC [auth DO],
WBA [auth BA],
WBB [auth DA],
WCA [auth BA],
WCB [auth DA],
WD [auth AA],
WDA [auth BA],
WDB [auth DA],
WE [auth AA],
WEA [auth BA],
WEB [auth DA],
WF [auth AA],
WFA [auth BA],
WFB [auth DA],
WG [auth AA],
WGA [auth BA],
WGB [auth DA],
WH [auth AA],
WHA [auth BA],
WHB [auth DA],
WI [auth AA],
WIA [auth BA],
WIB [auth DA],
WJ [auth AA],
WJA [auth BA],
WJB [auth DA],
WK [auth AA],
WKA [auth BA],
WKB [auth DA],
WL [auth AF],
WLA [auth BA],
WLB [auth DA],
WM [auth BA],
WMA [auth BA],
WMB [auth DA],
WN [auth BA],
WNA [auth BA],
WNB [auth DA],
WO [auth BA],
WOA [auth BA],
WOB [auth DA],
WP [auth BA],
WPA [auth BD],
WPB [auth DA],
WQ [auth BA],
WQA [auth BG],
WQB [auth DA],
WR [auth BA],
WRA [auth BU],
WRB [auth DA],
WS [auth BA],
WSA [auth B3],
WSB [auth DA],
WT [auth BA],
WTA [auth CA],
WTB [auth DA],
WU [auth BA],
WUA [auth CA],
WUB [auth DA],
WV [auth BA],
WVA [auth CA],
WVB [auth DA],
WW [auth BA],
WWA [auth CA],
WWB [auth DA],
WX [auth BA],
WXA [auth CA],
WXB [auth DA],
WY [auth BA],
WYA [auth CA],
WYB [auth DA],
WZ [auth BA],
WZA [auth CA],
WZB [auth DB],
XAA [auth BA],
XAB [auth DA],
XAC [auth DP],
XBA [auth BA],
XBB [auth DA],
XCA [auth BA],
XCB [auth DA],
XD [auth AA],
XDA [auth BA],
XDB [auth DA],
XE [auth AA],
XEA [auth BA],
XEB [auth DA],
XF [auth AA],
XFA [auth BA],
XFB [auth DA],
XG [auth AA],
XGA [auth BA],
XGB [auth DA],
XH [auth AA],
XHA [auth BA],
XHB [auth DA],
XI [auth AA],
XIA [auth BA],
XIB [auth DA],
XJ [auth AA],
XJA [auth BA],
XJB [auth DA],
XK [auth AA],
XKA [auth BA],
XKB [auth DA],
XL [auth AK],
XLA [auth BA],
XLB [auth DA],
XM [auth BA],
XMA [auth BA],
XMB [auth DA],
XN [auth BA],
XNA [auth BA],
XNB [auth DA],
XO [auth BA],
XOA [auth BA],
XOB [auth DA],
XP [auth BA],
XPA [auth BD],
XPB [auth DA],
XQ [auth BA],
XQA [auth BG],
XQB [auth DA],
XR [auth BA],
XRA [auth BU],
XRB [auth DA],
XS [auth BA],
XSB [auth DA],
XT [auth BA],
XTA [auth CA],
XTB [auth DA],
XU [auth BA],
XUA [auth CA],
XUB [auth DA],
XV [auth BA],
XVA [auth CA],
XVB [auth DA],
XW [auth BA],
XWA [auth CA],
XWB [auth DA],
XX [auth BA],
XXA [auth CA],
XXB [auth DA],
XY [auth BA],
XYA [auth CA],
XYB [auth DA],
XZ [auth BA],
XZA [auth CA],
XZB [auth DB],
YAA [auth BA],
YAB [auth DA],
YAC [auth DP],
YBA [auth BA],
YBB [auth DA],
YCA [auth BA],
YCB [auth DA],
YD [auth AA],
YDA [auth BA],
YDB [auth DA],
YE [auth AA],
YEA [auth BA],
YEB [auth DA],
YF [auth AA],
YFA [auth BA],
YFB [auth DA],
YG [auth AA],
YGA [auth BA],
YGB [auth DA],
YH [auth AA],
YHA [auth BA],
YHB [auth DA],
YI [auth AA],
YIA [auth BA],
YIB [auth DA],
YJ [auth AA],
YJA [auth BA],
YJB [auth DA],
YK [auth AA],
YKA [auth BA],
YKB [auth DA],
YL [auth AL],
YLA [auth BA],
YLB [auth DA],
YM [auth BA],
YMA [auth BA],
YMB [auth DA],
YN [auth BA],
YNA [auth BA],
YNB [auth DA],
YO [auth BA],
YOA [auth BA],
YOB [auth DA],
YP [auth BA],
YPA [auth BD],
YPB [auth DA],
YQ [auth BA],
YQA [auth BN],
YQB [auth DA],
YR [auth BA],
YRA [auth BU],
YRB [auth DA],
YS [auth BA],
YSB [auth DA],
YT [auth BA],
YTA [auth CA],
YTB [auth DA],
YU [auth BA],
YUA [auth CA],
YUB [auth DA],
YV [auth BA],
YVA [auth CA],
YVB [auth DA],
YW [auth BA],
YWA [auth CA],
YWB [auth DA],
YX [auth BA],
YXA [auth CA],
YXB [auth DA],
YY [auth BA],
YYA [auth CA],
YYB [auth DA],
YZ [auth BA],
YZA [auth CA],
YZB [auth DB],
ZAA [auth BA],
ZAB [auth DA],
ZAC [auth DQ],
ZBA [auth BA],
ZBB [auth DA],
ZCA [auth BA],
ZCB [auth DA],
ZD [auth AA],
ZDA [auth BA],
ZDB [auth DA],
ZE [auth AA],
ZEA [auth BA],
ZEB [auth DA],
ZF [auth AA],
ZFA [auth BA],
ZFB [auth DA],
ZG [auth AA],
ZGA [auth BA],
ZGB [auth DA],
ZH [auth AA],
ZHA [auth BA],
ZHB [auth DA],
ZI [auth AA],
ZIA [auth BA],
ZIB [auth DA],
ZJ [auth AA],
ZJA [auth BA],
ZJB [auth DA],
ZK [auth AA],
ZKA [auth BA],
ZKB [auth DA],
ZL [auth AM],
ZLA [auth BA],
ZLB [auth DA],
ZM [auth BA],
ZMA [auth BA],
ZMB [auth DA],
ZN [auth BA],
ZNA [auth BA],
ZNB [auth DA],
ZO [auth BA],
ZOA [auth BA],
ZOB [auth DA],
ZP [auth BA],
ZPA [auth BD],
ZPB [auth DA],
ZQ [auth BA],
ZQA [auth BN],
ZQB [auth DA],
ZR [auth BA],
ZRA [auth BV],
ZRB [auth DA],
ZS [auth BA],
ZSA [auth B5],
ZSB [auth DA],
ZT [auth BA],
ZTA [auth CA],
ZTB [auth DA],
ZU [auth BA],
ZUA [auth CA],
ZUB [auth DA],
ZV [auth BA],
ZVA [auth CA],
ZVB [auth DA],
ZW [auth BA],
ZWA [auth CA],
ZWB [auth DA],
ZX [auth BA],
ZXA [auth CA],
ZXB [auth DA],
ZY [auth BA],
ZYA [auth CA],
ZYB [auth DA],
ZZ [auth BA],
ZZB [auth DB]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Modified Residues  3 Unique
IDChains TypeFormula2D DiagramParent
2QZ
Query on 2QZ
AC [auth CW],
X [auth AW]
L-PEPTIDE LINKINGC6 H13 N O3THR
2R3
Query on 2R3
AC [auth CW],
X [auth AW]
L-PEPTIDE LINKINGC10 H13 N O4TYR
MVA
Query on MVA
AC [auth CW],
X [auth AW]
L-PEPTIDE LINKINGC6 H13 N O2VAL
Biologically Interesting Molecules (External Reference) 1 Unique
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.00 Å
  • R-Value Free: 0.259 
  • R-Value Work: 0.203 
  • R-Value Observed: 0.206 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 210.08α = 90
b = 449.83β = 90
c = 619.65γ = 90
Software Package:
Software NamePurpose
XSCALEdata scaling
PHASERphasing
PHENIXrefinement
PDB_EXTRACTdata extraction
XDSdata reduction

Structure Validation

View Full Validation Report



Ligand Structure Quality Assessment 


Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2014-07-09
    Type: Initial release
  • Version 1.1: 2014-12-10
    Changes: Other