4V7L

The structures of viomycin bound to the 70S ribosome.

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.00 Å
  • R-Value Free: 0.272 
  • R-Value Work: 0.248 

wwPDB Validation   3D Report Full Report


This is version 1.2 of the entry. See complete history. 


Literature

The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.

Stanley, R.E., Blaha, G., Grodzicki, R.L., Strickler, M.D., Steitz, T.A.

(2010) Nat Struct Mol Biol 17: 289-293

  • DOI: https://doi.org/10.1038/nsmb.1755
  • Primary Citation of Related Structures:  
    4V7L, 4V7M

  • PubMed Abstract: 

    Viomycin and capreomycin belong to the tuberactinomycin family of antibiotics, which are among the most effective antibiotics against multidrug-resistant tuberculosis. Here we present two crystal structures of the 70S ribosome in complex with three tRNAs and bound to either viomycin or capreomycin at 3.3- and 3.5-A resolution, respectively. Both antibiotics bind to the same site on the ribosome, which lies at the interface between helix 44 of the small ribosomal subunit and helix 69 of the large ribosomal subunit. The structures of these complexes suggest that the tuberactinomycins inhibit translocation by stabilizing the tRNA in the A site in the pretranslocation state. In addition, these structures show that the tuberactinomycins bind adjacent to the binding sites for the paromomycin and hygromycin B antibiotics, which may enable the development of new derivatives of tuberactinomycins that are effective against drug-resistant strains.

    • Organizational Affiliation: 

    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA.


Macromolecules

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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S2B [auth AB],
HB [auth CB]		256Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S3C [auth AC],
IB [auth CC]		239Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S4D [auth AD],
JB [auth CD]		209Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S5E [auth AE],
KB [auth CE]		162Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S6F [auth AF],
LB [auth CF]		101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S7G [auth AG],
MB [auth CG]		156Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S8H [auth AH],
NB [auth CH]		138Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S9I [auth AI],
OB [auth CI]		128Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S10J [auth AJ],
PB [auth CJ]		105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S11K [auth AK],
QB [auth CK]		129Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S12L [auth AL],
RB [auth CL]		132Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S13M [auth AM],
SB [auth CM]		126Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S14N [auth AN],
TB [auth CN]		61Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S15O [auth AO],
UB [auth CO]		89Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S16P [auth AP],
VB [auth CP]		88Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S17Q [auth AQ],
WB [auth CQ]		105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S18R [auth AR],
XB [auth CR]		88Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S19S [auth AS],
YB [auth CS]		93Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S20T [auth AT],
ZB [auth CT]		106Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein ThxAC [auth CU],
U [auth AU]		27Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 26
MoleculeChains Sequence LengthOrganismDetailsImage
ViomycinFC [auth CZ],
Z [auth AZ]		6Streptomyces californicusMutation(s): 0 
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L1CA [auth BC],
IC [auth DC]		229Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L2DA [auth BD],
JC [auth DD]		276Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 31
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L3EA [auth BE],
KC [auth DE]		206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 32
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L4FA [auth BF],
LC [auth DF]		210Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L5GA [auth BG],
MC [auth DG]		182Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 34
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L6HA [auth BH],
NC [auth DH]		180Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L9IA [auth BI],
OC [auth DI]		148Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L13JA [auth BN],
PC [auth DN]		140Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L14KA [auth BO],
QC [auth DO]		122Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L15LA [auth BP],
RC [auth DP]		150Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L16MA [auth BQ],
SC [auth DQ]		141Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L17NA [auth BR],
TC [auth DR]		118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L18OA [auth BS],
UC [auth DS]		112Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L19PA [auth BT],
VC [auth DT]		146Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L20QA [auth BU],
WC [auth DU]		118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L21RA [auth BV],
XC [auth DV]		101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L22SA [auth BW],
YC [auth DW]		113Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 46
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L23TA [auth BX],
ZC [auth DX]		96Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L24AD [auth DY],
UA [auth BY]		110Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L25BD [auth DZ],
VA [auth BZ]		206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L27CD [auth D0],
WA [auth B0]		85Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L28DD [auth D1],
XA [auth B1]		98Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L29ED [auth D2],
YA [auth B2]		72Thermus thermophilus HB8Mutation(s): 0 
UniProt
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UniProt GroupQ5SHP6
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Entity ID: 52
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L30FD [auth D3],
ZA [auth B3]		60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 53
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L31AB [auth B4],
GD [auth D4]		71Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 54
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L32BB [auth B5],
HD [auth D5]		60Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 55
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L33CB [auth B6],
ID [auth D6]		54Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 56
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L34DB [auth B7],
JD [auth D7]		49Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 57
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L35EB [auth B8],
KD [auth D8]		65Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SKU1 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 58
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L36FB [auth B9],
LD [auth D9]		37Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SHR2 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 1
MoleculeChains LengthOrganismImage
16S ribosomal RNAA [auth AA],
GB [auth CA]		1,509Thermus thermophilus HB8
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Entity ID: 22
MoleculeChains LengthOrganismImage
RNA (5'-R(*AP*AP*AP*AP*AP*GP*GP*AP*AP*AP*UP*A*AP*AP*AP*AP*UP*GP*CP*AP*GP*UP*UP*CP*AP*AP*UP*CP*UP*A)-3')BC [auth CV],
V [auth AV]		30N/A
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Entity ID: 23
MoleculeChains LengthOrganismImage
tRNA-GlnCC [auth CW],
W [auth AW]		75Escherichia coli DH1
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Entity ID: 24
MoleculeChains LengthOrganismImage
tRNA-MetDC [auth CX],
X [auth AX]		77Escherichia coli DH1
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Entity ID: 25
MoleculeChains LengthOrganismImage
tRNA-GlnEC [auth CY],
Y [auth AY]		75Escherichia coli DH1
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Entity ID: 27
MoleculeChains LengthOrganismImage
23S ribosomal RNAAA [auth BA],
GC [auth DA]		2,915Thermus thermophilus HB8
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Entity ID: 28
MoleculeChains LengthOrganismImage
5S ribosomal RNABA [auth BB],
HC [auth DB]		122Thermus thermophilus HB8
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Small Molecules
Ligands 2 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
ZN
Query on ZN
Download Ideal Coordinates CCD File 
JDA [auth CD]
RI [auth AD]
ROA [auth D4]
RZ [auth B4]
TZ [auth B5]
JDA [auth CD],
RI [auth AD],
ROA [auth D4],
RZ [auth B4],
TZ [auth B5],
UOA [auth D5],
UZ [auth B9],
WOA [auth D9]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
MG
Query on MG
Download Ideal Coordinates CCD File 
AAA [auth CA]
ABA [auth CA]
ACA [auth CA]
ADA [auth CA]
AE [auth AA]
AAA [auth CA],
ABA [auth CA],
ACA [auth CA],
ADA [auth CA],
AE [auth AA],
AEA [auth DA],
AF [auth AA],
AFA [auth DA],
AG [auth AA],
AGA [auth DA],
AH [auth AA],
AHA [auth DA],
AI [auth AA],
AIA [auth DA],
AJ [auth AT],
AJA [auth DA],
AK [auth BA],
AKA [auth DA],
AL [auth BA],
ALA [auth DA],
AM [auth BA],
AMA [auth DA],
AN [auth BA],
ANA [auth DA],
AO [auth BA],
AOA [auth DA],
AP [auth BA],
AQ [auth BA],
AR [auth BA],
AS [auth BA],
AT [auth BA],
AU [auth BA],
AV [auth BA],
AW [auth BA],
AX [auth BA],
AY [auth BA],
AZ [auth BA],
BAA [auth CA],
BBA [auth CA],
BCA [auth CA],
BDA [auth CA],
BE [auth AA],
BEA [auth DA],
BF [auth AA],
BFA [auth DA],
BG [auth AA],
BGA [auth DA],
BH [auth AA],
BHA [auth DA],
BI [auth AA],
BIA [auth DA],
BJ [auth AW],
BJA [auth DA],
BK [auth BA],
BKA [auth DA],
BL [auth BA],
BLA [auth DA],
BM [auth BA],
BMA [auth DA],
BN [auth BA],
BNA [auth DA],
BO [auth BA],
BOA [auth DA],
BP [auth BA],
BQ [auth BA],
BR [auth BA],
BS [auth BA],
BT [auth BA],
BU [auth BA],
BV [auth BA],
BW [auth BA],
BX [auth BA],
BY [auth BA],
BZ [auth BB],
CAA [auth CA],
CBA [auth CA],
CCA [auth CA],
CDA [auth CA],
CE [auth AA],
CEA [auth DA],
CF [auth AA],
CFA [auth DA],
CG [auth AA],
CGA [auth DA],
CH [auth AA],
CHA [auth DA],
CI [auth AA],
CIA [auth DA],
CJ [auth AW],
CJA [auth DA],
CK [auth BA],
CKA [auth DA],
CL [auth BA],
CLA [auth DA],
CM [auth BA],
CMA [auth DA],
CN [auth BA],
CNA [auth DA],
CO [auth BA],
COA [auth DA],
CP [auth BA],
CQ [auth BA],
CR [auth BA],
CS [auth BA],
CT [auth BA],
CU [auth BA],
CV [auth BA],
CW [auth BA],
CX [auth BA],
CY [auth BA],
CZ [auth BD],
DAA [auth CA],
DBA [auth CA],
DCA [auth CA],
DDA [auth CA],
DE [auth AA],
DEA [auth DA],
DF [auth AA],
DFA [auth DA],
DG [auth AA],
DGA [auth DA],
DH [auth AA],
DHA [auth DA],
DI [auth AA],
DIA [auth DA],
DJ [auth AW],
DJA [auth DA],
DK [auth BA],
DKA [auth DA],
DL [auth BA],
DLA [auth DA],
DM [auth BA],
DMA [auth DA],
DN [auth BA],
DNA [auth DA],
DO [auth BA],
DOA [auth DA],
DP [auth BA],
DQ [auth BA],
DR [auth BA],
DS [auth BA],
DT [auth BA],
DU [auth BA],
DV [auth BA],
DW [auth BA],
DX [auth BA],
DY [auth BA],
DZ [auth BE],
EAA [auth CA],
EBA [auth CA],
ECA [auth CA],
EDA [auth CA],
EE [auth AA],
EEA [auth DA],
EF [auth AA],
EFA [auth DA],
EG [auth AA],
EGA [auth DA],
EH [auth AA],
EHA [auth DA],
EI [auth AA],
EIA [auth DA],
EJ [auth AW],
EJA [auth DA],
EK [auth BA],
EKA [auth DA],
EL [auth BA],
ELA [auth DA],
EM [auth BA],
EMA [auth DA],
EN [auth BA],
ENA [auth DA],
EO [auth BA],
EOA [auth DA],
EP [auth BA],
EQ [auth BA],
ER [auth BA],
ES [auth BA],
ET [auth BA],
EU [auth BA],
EV [auth BA],
EW [auth BA],
EX [auth BA],
EY [auth BA],
EZ [auth BF],
FAA [auth CA],
FBA [auth CA],
FCA [auth CA],
FDA [auth CA],
FE [auth AA],
FEA [auth DA],
FF [auth AA],
FFA [auth DA],
FG [auth AA],
FGA [auth DA],
FH [auth AA],
FHA [auth DA],
FI [auth AA],
FIA [auth DA],
FJ [auth AW],
FJA [auth DA],
FK [auth BA],
FKA [auth DA],
FL [auth BA],
FLA [auth DA],
FM [auth BA],
FMA [auth DA],
FN [auth BA],
FNA [auth DA],
FO [auth BA],
FOA [auth DA],
FP [auth BA],
FQ [auth BA],
FR [auth BA],
FS [auth BA],
FT [auth BA],
FU [auth BA],
FV [auth BA],
FW [auth BA],
FX [auth BA],
FY [auth BA],
FZ [auth BF],
GAA [auth CA],
GBA [auth CA],
GCA [auth CA],
GDA [auth CA],
GE [auth AA],
GEA [auth DA],
GF [auth AA],
GFA [auth DA],
GG [auth AA],
GGA [auth DA],
GH [auth AA],
GHA [auth DA],
GI [auth AA],
GIA [auth DA],
GJ [auth AW],
GJA [auth DA],
GK [auth BA],
GKA [auth DA],
GL [auth BA],
GLA [auth DA],
GM [auth BA],
GMA [auth DA],
GN [auth BA],
GNA [auth DA],
GO [auth BA],
GOA [auth DA],
GP [auth BA],
GQ [auth BA],
GR [auth BA],
GS [auth BA],
GT [auth BA],
GU [auth BA],
GV [auth BA],
GW [auth BA],
GX [auth BA],
GY [auth BA],
GZ [auth BH],
HAA [auth CA],
HBA [auth CA],
HCA [auth CA],
HDA [auth CA],
HE [auth AA],
HEA [auth DA],
HF [auth AA],
HFA [auth DA],
HG [auth AA],
HGA [auth DA],
HH [auth AA],
HHA [auth DA],
HI [auth AA],
HIA [auth DA],
HJ [auth AW],
HJA [auth DA],
HK [auth BA],
HKA [auth DA],
HL [auth BA],
HLA [auth DA],
HM [auth BA],
HMA [auth DA],
HN [auth BA],
HNA [auth DA],
HO [auth BA],
HOA [auth DB],
HP [auth BA],
HQ [auth BA],
HR [auth BA],
HS [auth BA],
HT [auth BA],
HU [auth BA],
HV [auth BA],
HW [auth BA],
HX [auth BA],
HY [auth BA],
HZ [auth BN],
IAA [auth CA],
IBA [auth CA],
ICA [auth CA],
IDA [auth CA],
IE [auth AA],
IEA [auth DA],
IF [auth AA],
IFA [auth DA],
IG [auth AA],
IGA [auth DA],
IH [auth AA],
IHA [auth DA],
II [auth AA],
IIA [auth DA],
IJ [auth AX],
IJA [auth DA],
IK [auth BA],
IKA [auth DA],
IL [auth BA],
ILA [auth DA],
IM [auth BA],
IMA [auth DA],
IN [auth BA],
INA [auth DA],
IO [auth BA],
IOA [auth DD],
IP [auth BA],
IQ [auth BA],
IR [auth BA],
IS [auth BA],
IT [auth BA],
IU [auth BA],
IV [auth BA],
IW [auth BA],
IX [auth BA],
IY [auth BA],
IZ [auth BP],
JAA [auth CA],
JBA [auth CA],
JCA [auth CA],
JE [auth AA],
JEA [auth DA],
JF [auth AA],
JFA [auth DA],
JG [auth AA],
JGA [auth DA],
JH [auth AA],
JHA [auth DA],
JI [auth AA],
JIA [auth DA],
JJ [auth AX],
JJA [auth DA],
JK [auth BA],
JKA [auth DA],
JL [auth BA],
JLA [auth DA],
JM [auth BA],
JMA [auth DA],
JN [auth BA],
JNA [auth DA],
JO [auth BA],
JOA [auth DD],
JP [auth BA],
JQ [auth BA],
JR [auth BA],
JS [auth BA],
JT [auth BA],
JU [auth BA],
JV [auth BA],
JW [auth BA],
JX [auth BA],
JY [auth BA],
JZ [auth BQ],
KAA [auth CA],
KBA [auth CA],
KCA [auth CA],
KDA [auth CE],
KE [auth AA],
KEA [auth DA],
KF [auth AA],
KFA [auth DA],
KG [auth AA],
KGA [auth DA],
KH [auth AA],
KHA [auth DA],
KI [auth AA],
KIA [auth DA],
KJ [auth AX],
KJA [auth DA],
KK [auth BA],
KKA [auth DA],
KL [auth BA],
KLA [auth DA],
KM [auth BA],
KMA [auth DA],
KN [auth BA],
KNA [auth DA],
KO [auth BA],
KOA [auth DD],
KP [auth BA],
KQ [auth BA],
KR [auth BA],
KS [auth BA],
KT [auth BA],
KU [auth BA],
KV [auth BA],
KW [auth BA],
KX [auth BA],
KY [auth BA],
KZ [auth BR],
LAA [auth CA],
LBA [auth CA],
LCA [auth CA],
LDA [auth CE],
LE [auth AA],
LEA [auth DA],
LF [auth AA],
LFA [auth DA],
LG [auth AA],
LGA [auth DA],
LH [auth AA],
LHA [auth DA],
LI [auth AA],
LIA [auth DA],
LJ [auth AX],
LJA [auth DA],
LK [auth BA],
LKA [auth DA],
LL [auth BA],
LLA [auth DA],
LM [auth BA],
LMA [auth DA],
LN [auth BA],
LNA [auth DA],
LO [auth BA],
LOA [auth DE],
LP [auth BA],
LQ [auth BA],
LR [auth BA],
LS [auth BA],
LT [auth BA],
LU [auth BA],
LV [auth BA],
LW [auth BA],
LX [auth BA],
LY [auth BA],
LZ [auth BU],
MAA [auth CA],
MBA [auth CA],
MCA [auth CA],
MD [auth AA],
MDA [auth CQ],
ME [auth AA],
MEA [auth DA],
MF [auth AA],
MFA [auth DA],
MG [auth AA],
MGA [auth DA],
MH [auth AA],
MHA [auth DA],
MI [auth AA],
MIA [auth DA],
MJ [auth AX],
MJA [auth DA],
MK [auth BA],
MKA [auth DA],
ML [auth BA],
MLA [auth DA],
MM [auth BA],
MMA [auth DA],
MN [auth BA],
MNA [auth DA],
MO [auth BA],
MOA [auth DE],
MP [auth BA],
MQ [auth BA],
MR [auth BA],
MS [auth BA],
MT [auth BA],
MU [auth BA],
MV [auth BA],
MW [auth BA],
MX [auth BA],
MY [auth BA],
MZ [auth BX],
NAA [auth CA],
NBA [auth CA],
NCA [auth CA],
ND [auth AA],
NDA [auth CV],
NE [auth AA],
NEA [auth DA],
NF [auth AA],
NFA [auth DA],
NG [auth AA],
NGA [auth DA],
NH [auth AA],
NHA [auth DA],
NI [auth AA],
NIA [auth DA],
NJ [auth AX],
NJA [auth DA],
NK [auth BA],
NKA [auth DA],
NL [auth BA],
NLA [auth DA],
NM [auth BA],
NMA [auth DA],
NN [auth BA],
NNA [auth DA],
NO [auth BA],
NOA [auth DE],
NP [auth BA],
NQ [auth BA],
NR [auth BA],
NS [auth BA],
NT [auth BA],
NU [auth BA],
NV [auth BA],
NW [auth BA],
NX [auth BA],
NY [auth BA],
NZ [auth BY],
OAA [auth CA],
OBA [auth CA],
OCA [auth CA],
OD [auth AA],
ODA [auth CV],
OE [auth AA],
OEA [auth DA],
OF [auth AA],
OFA [auth DA],
OG [auth AA],
OGA [auth DA],
OH [auth AA],
OHA [auth DA],
OI [auth AA],
OIA [auth DA],
OJ [auth AX],
OJA [auth DA],
OK [auth BA],
OKA [auth DA],
OL [auth BA],
OLA [auth DA],
OM [auth BA],
OMA [auth DA],
ON [auth BA],
ONA [auth DA],
OO [auth BA],
OOA [auth DF],
OP [auth BA],
OQ [auth BA],
OR [auth BA],
OS [auth BA],
OT [auth BA],
OU [auth BA],
OV [auth BA],
OW [auth BA],
OX [auth BA],
OY [auth BA],
OZ [auth BZ],
PAA [auth CA],
PBA [auth CA],
PCA [auth CA],
PD [auth AA],
PDA [auth CX],
PE [auth AA],
PEA [auth DA],
PF [auth AA],
PFA [auth DA],
PG [auth AA],
PGA [auth DA],
PH [auth AA],
PHA [auth DA],
PI [auth AC],
PIA [auth DA],
PJ [auth AY],
PJA [auth DA],
PK [auth BA],
PKA [auth DA],
PL [auth BA],
PLA [auth DA],
PM [auth BA],
PMA [auth DA],
PN [auth BA],
PNA [auth DA],
PO [auth BA],
POA [auth DR],
PP [auth BA],
PQ [auth BA],
PR [auth BA],
PS [auth BA],
PT [auth BA],
PU [auth BA],
PV [auth BA],
PW [auth BA],
PX [auth BA],
PY [auth BA],
PZ [auth B0],
QAA [auth CA],
QBA [auth CA],
QCA [auth CA],
QD [auth AA],
QDA [auth CX],
QE [auth AA],
QEA [auth DA],
QF [auth AA],
QFA [auth DA],
QG [auth AA],
QGA [auth DA],
QH [auth AA],
QHA [auth DA],
QI [auth AD],
QIA [auth DA],
QJ [auth AY],
QJA [auth DA],
QK [auth BA],
QKA [auth DA],
QL [auth BA],
QLA [auth DA],
QM [auth BA],
QMA [auth DA],
QN [auth BA],
QNA [auth DA],
QO [auth BA],
QOA [auth DZ],
QP [auth BA],
QQ [auth BA],
QR [auth BA],
QS [auth BA],
QT [auth BA],
QU [auth BA],
QV [auth BA],
QW [auth BA],
QX [auth BA],
QY [auth BA],
QZ [auth B0],
RAA [auth CA],
RBA [auth CA],
RCA [auth CA],
RD [auth AA],
RDA [auth CX],
RE [auth AA],
REA [auth DA],
RF [auth AA],
RFA [auth DA],
RG [auth AA],
RGA [auth DA],
RH [auth AA],
RHA [auth DA],
RIA [auth DA],
RJ [auth BA],
RJA [auth DA],
RK [auth BA],
RKA [auth DA],
RL [auth BA],
RLA [auth DA],
RM [auth BA],
RMA [auth DA],
RN [auth BA],
RNA [auth DA],
RO [auth BA],
RP [auth BA],
RQ [auth BA],
RR [auth BA],
RS [auth BA],
RT [auth BA],
RU [auth BA],
RV [auth BA],
RW [auth BA],
RX [auth BA],
RY [auth BA],
SAA [auth CA],
SBA [auth CA],
SCA [auth CA],
SD [auth AA],
SDA [auth DA],
SE [auth AA],
SEA [auth DA],
SF [auth AA],
SFA [auth DA],
SG [auth AA],
SGA [auth DA],
SH [auth AA],
SHA [auth DA],
SI [auth AE],
SIA [auth DA],
SJ [auth BA],
SJA [auth DA],
SK [auth BA],
SKA [auth DA],
SL [auth BA],
SLA [auth DA],
SM [auth BA],
SMA [auth DA],
SN [auth BA],
SNA [auth DA],
SO [auth BA],
SOA [auth D5],
SP [auth BA],
SQ [auth BA],
SR [auth BA],
SS [auth BA],
ST [auth BA],
SU [auth BA],
SV [auth BA],
SW [auth BA],
SX [auth BA],
SY [auth BA],
SZ [auth B5],
TAA [auth CA],
TBA [auth CA],
TCA [auth CA],
TD [auth AA],
TDA [auth DA],
TE [auth AA],
TEA [auth DA],
TF [auth AA],
TFA [auth DA],
TG [auth AA],
TGA [auth DA],
TH [auth AA],
THA [auth DA],
TI [auth AF],
TIA [auth DA],
TJ [auth BA],
TJA [auth DA],
TK [auth BA],
TKA [auth DA],
TL [auth BA],
TLA [auth DA],
TM [auth BA],
TMA [auth DA],
TN [auth BA],
TNA [auth DA],
TO [auth BA],
TOA [auth D5],
TP [auth BA],
TQ [auth BA],
TR [auth BA],
TS [auth BA],
TT [auth BA],
TU [auth BA],
TV [auth BA],
TW [auth BA],
TX [auth BA],
TY [auth BA],
UAA [auth CA],
UBA [auth CA],
UCA [auth CA],
UD [auth AA],
UDA [auth DA],
UE [auth AA],
UEA [auth DA],
UF [auth AA],
UFA [auth DA],
UG [auth AA],
UGA [auth DA],
UH [auth AA],
UHA [auth DA],
UI [auth AH],
UIA [auth DA],
UJ [auth BA],
UJA [auth DA],
UK [auth BA],
UKA [auth DA],
UL [auth BA],
ULA [auth DA],
UM [auth BA],
UMA [auth DA],
UN [auth BA],
UNA [auth DA],
UO [auth BA],
UP [auth BA],
UQ [auth BA],
UR [auth BA],
US [auth BA],
UT [auth BA],
UU [auth BA],
UV [auth BA],
UW [auth BA],
UX [auth BA],
UY [auth BA],
VAA [auth CA],
VBA [auth CA],
VCA [auth CA],
VD [auth AA],
VDA [auth DA],
VE [auth AA],
VEA [auth DA],
VF [auth AA],
VFA [auth DA],
VG [auth AA],
VGA [auth DA],
VH [auth AA],
VHA [auth DA],
VI [auth AK],
VIA [auth DA],
VJ [auth BA],
VJA [auth DA],
VK [auth BA],
VKA [auth DA],
VL [auth BA],
VLA [auth DA],
VM [auth BA],
VMA [auth DA],
VN [auth BA],
VNA [auth DA],
VO [auth BA],
VOA [auth D6],
VP [auth BA],
VQ [auth BA],
VR [auth BA],
VS [auth BA],
VT [auth BA],
VU [auth BA],
VV [auth BA],
VW [auth BA],
VX [auth BA],
VY [auth BA],
VZ [auth CA],
WAA [auth CA],
WBA [auth CA],
WCA [auth CA],
WD [auth AA],
WDA [auth DA],
WE [auth AA],
WEA [auth DA],
WF [auth AA],
WFA [auth DA],
WG [auth AA],
WGA [auth DA],
WH [auth AA],
WHA [auth DA],
WI [auth AK],
WIA [auth DA],
WJ [auth BA],
WJA [auth DA],
WK [auth BA],
WKA [auth DA],
WL [auth BA],
WLA [auth DA],
WM [auth BA],
WMA [auth DA],
WN [auth BA],
WNA [auth DA],
WO [auth BA],
WP [auth BA],
WQ [auth BA],
WR [auth BA],
WS [auth BA],
WT [auth BA],
WU [auth BA],
WV [auth BA],
WW [auth BA],
WX [auth BA],
WY [auth BA],
WZ [auth CA],
XAA [auth CA],
XBA [auth CA],
XCA [auth CA],
XD [auth AA],
XDA [auth DA],
XE [auth AA],
XEA [auth DA],
XF [auth AA],
XFA [auth DA],
XG [auth AA],
XGA [auth DA],
XH [auth AA],
XHA [auth DA],
XI [auth AL],
XIA [auth DA],
XJ [auth BA],
XJA [auth DA],
XK [auth BA],
XKA [auth DA],
XL [auth BA],
XLA [auth DA],
XM [auth BA],
XMA [auth DA],
XN [auth BA],
XNA [auth DA],
XO [auth BA],
XP [auth BA],
XQ [auth BA],
XR [auth BA],
XS [auth BA],
XT [auth BA],
XU [auth BA],
XV [auth BA],
XW [auth BA],
XX [auth BA],
XY [auth BA],
XZ [auth CA],
YAA [auth CA],
YBA [auth CA],
YCA [auth CA],
YD [auth AA],
YDA [auth DA],
YE [auth AA],
YEA [auth DA],
YF [auth AA],
YFA [auth DA],
YG [auth AA],
YGA [auth DA],
YH [auth AA],
YHA [auth DA],
YI [auth AO],
YIA [auth DA],
YJ [auth BA],
YJA [auth DA],
YK [auth BA],
YKA [auth DA],
YL [auth BA],
YLA [auth DA],
YM [auth BA],
YMA [auth DA],
YN [auth BA],
YNA [auth DA],
YO [auth BA],
YP [auth BA],
YQ [auth BA],
YR [auth BA],
YS [auth BA],
YT [auth BA],
YU [auth BA],
YV [auth BA],
YW [auth BA],
YX [auth BA],
YY [auth BA],
YZ [auth CA],
ZAA [auth CA],
ZBA [auth CA],
ZCA [auth CA],
ZD [auth AA],
ZDA [auth DA],
ZE [auth AA],
ZEA [auth DA],
ZF [auth AA],
ZFA [auth DA],
ZG [auth AA],
ZGA [auth DA],
ZH [auth AA],
ZHA [auth DA],
ZI [auth AT],
ZIA [auth DA],
ZJ [auth BA],
ZJA [auth DA],
ZK [auth BA],
ZKA [auth DA],
ZL [auth BA],
ZLA [auth DA],
ZM [auth BA],
ZMA [auth DA],
ZN [auth BA],
ZNA [auth DA],
ZO [auth BA],
ZP [auth BA],
ZQ [auth BA],
ZR [auth BA],
ZS [auth BA],
ZT [auth BA],
ZU [auth BA],
ZV [auth BA],
ZW [auth BA],
ZX [auth BA],
ZY [auth BA],
ZZ [auth CA]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Modified Residues  3 Unique
IDChains TypeFormula2D DiagramParent
5OH
Query on 5OH		FC [auth CZ],
Z [auth AZ]		L-PEPTIDE LINKINGC6 H12 N4 O3ALA
DPP
Query on DPP		FC [auth CZ],
Z [auth AZ]		L-PEPTIDE LINKINGC3 H8 N2 O2ALA
KBE
Query on KBE		FC [auth CZ],
Z [auth AZ]		L-PEPTIDE LINKINGC6 H14 N2 O2LYS
Biologically Interesting Molecules (External Reference) 1 Unique
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.00 Å
  • R-Value Free: 0.272 
  • R-Value Work: 0.248 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 210.23α = 90
b = 448.51β = 90
c = 633.62γ = 90
Software Package:
Software NamePurpose
XSCALEdata scaling
PHASERphasing
CNSrefinement
PDB_EXTRACTdata extraction
CBASSdata collection

Structure Validation

View Full Validation Report



View more in-depth experimental data
Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2014-07-09
    Type: Initial release
  • Version 1.1: 2014-12-10
    Changes: Other
  • Version 1.2: 2018-07-11
    Changes: Advisory, Data collection, Derived calculations