Download MendeleyCrystal Structure Analysis of the Human Leukotriene A4 Hydrolase
Ouyang, P., Lu, W., Cui, K., Huang, J.To be published.
4RVB
Crystal Structure Analysis of the Human Leukotriene A4 Hydrolase
- PDB DOI: https://doi.org/10.2210/pdb4RVB/pdb
- Classification: HYDROLASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2014-11-25 Released: 2015-12-02
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.93 Å
- R-Value Free: 0.178
- R-Value Work: 0.144
- R-Value Observed: 0.146
wwPDB Validation 3D Report Full Report
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Leukotriene A-4 hydrolase | 631 | Homo sapiens | Mutation(s): 0 Gene Names: LTA4H, LTA4 EC: 3.3.2.6 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P09960 (Homo sapiens) Explore P09960 Go to UniProtKB: P09960 | |||||
PHAROS: P09960 GTEx: ENSG00000111144 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P09960 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 6 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| YB Query on YB | B [auth A] | YTTERBIUM (III) ION Yb AWSFICBXMUKWSK-UHFFFAOYSA-N |  | ||
| GOL Query on GOL | I [auth A], J [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| IMD Query on IMD | F [auth A], G [auth A], H [auth A] | IMIDAZOLE C3 H5 N2 RAXXELZNTBOGNW-UHFFFAOYSA-O |  | ||
| ZN Query on ZN | C [auth A] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |  | ||
| ACY Query on ACY | K [auth A], L [auth A] | ACETIC ACID C2 H4 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-N |  | ||
| ACT Query on ACT | D [auth A], E [auth A] | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.93 Å
- R-Value Free: 0.178
- R-Value Work: 0.144
- R-Value Observed: 0.146
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 77.939 | α = 90 |
| b = 87.153 | β = 90 |
| c = 99.228 | γ = 90 |
| Software Name | Purpose |
|---|---|
| HKL-2000 | data collection |
| MOLREP | phasing |
| REFMAC | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
Entry History
Deposition Data
- Released Date: 2015-12-02 Deposition Author(s): Ouyang, P., Lu, W., Cui, K., Huang, J.
Revision History (Full details and data files)
- Version 1.0: 2015-12-02
Type: Initial release - Version 1.1: 2023-11-08
Changes: Data collection, Database references, Derived calculations, Refinement description
