4K94
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19
- PDB DOI: https://doi.org/10.2210/pdb4K94/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3), unidentified baculovirus
- Mutation(s): No 
- Deposited: 2013-04-19 Released: 2013-10-16 
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 Å
- R-Value Free: 0.235 
- R-Value Work: 0.198 
- R-Value Observed: 0.200 
This is version 1.3 of the entry. See complete history. 
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Fab19 heavy chain | A [auth L] | 226 | Homo sapiens | Mutation(s): 0  | |
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Fab19 light chain | B [auth H] | 220 | Homo sapiens | Mutation(s): 0  | |
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Mast/stem cell growth factor receptor Kit | 214 | Homo sapiens | Mutation(s): 0  Gene Names: KIT, SCFR EC: 2.7.10.1 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P10721 (Homo sapiens) Explore P10721  Go to UniProtKB:  P10721 | |||||
PHAROS:  P10721 GTEx:  ENSG00000157404  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P10721 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
Ligands 1 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
NAG Query on NAG | D [auth C] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 Å
- R-Value Free: 0.235 
- R-Value Work: 0.198 
- R-Value Observed: 0.200 
- Space Group: C 1 2 1
- Diffraction Data: https://doi.org/10.15785/SBGRID/164
Unit Cell:
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 169.58 | α = 90 |
b = 48.98 | β = 122.38 |
c = 106.97 | γ = 90 |
Software Name | Purpose |
---|---|
CBASS | data collection |
PHASER | phasing |
PHENIX | refinement |
HKL-2000 | data reduction |
HKL-2000 | data scaling |
Entry History 
Deposition Data
- Released Date: 2013-10-16  Deposition Author(s): Resheynyak, A.V., Boggon, T.J., Lax, I., Schlessinger, J.
Revision History (Full details and data files)
- Version 1.0: 2013-10-16
Type: Initial release - Version 1.1: 2014-03-12
Changes: Database references - Version 1.2: 2014-04-09
Changes: Source and taxonomy - Version 1.3: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Data collection, Database references, Derived calculations, Structure summary