Download MendeleyPotent antiviral activity of the novel HIV entry inhibitor MTSFT
Yao, X., Chong, H.H., Waltersperger, S., Wang, M.T., He, Y.X., Cui, S.To be published.
4I2L
New HIV entry inhibitor MTSFT/T23 complex
- PDB DOI: https://doi.org/10.2210/pdb4I2L/pdb
- Classification: VIRAL PROTEIN/ANTIVIRAL PROTEIN
- Organism(s): Human immunodeficiency virus type 1 (ZAIRE 6 ISOLATE)
- Mutation(s): Yes
- Deposited: 2012-11-22 Released: 2014-01-22
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.43 Å
- R-Value Free: 0.242
- R-Value Work: 0.216
- R-Value Observed: 0.217
wwPDB Validation 3D Report Full Report
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| GP41 | A [auth C] | 42 | Human immunodeficiency virus type 1 (ZAIRE 6 ISOLATE) | Mutation(s): 1 |  |
UniProt | |||||
Find proteins for P04580 (Human immunodeficiency virus type 1 group M subtype D (isolate Z6)) Explore P04580 Go to UniProtKB: P04580 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P04580 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| inhibitor MTSFT | B [auth D] | 38 | N/A | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.43 Å
- R-Value Free: 0.242
- R-Value Work: 0.216
- R-Value Observed: 0.217
- Space Group: H 3 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 43.948 | α = 90 |
| b = 43.948 | β = 90 |
| c = 238.439 | γ = 120 |
| Software Name | Purpose |
|---|---|
| RemDAq | data collection |
| PHASER | phasing |
| PHENIX | refinement |
| XDS | data reduction |
| XDS | data scaling |
Entry History
Deposition Data
- Released Date: 2014-01-22 Deposition Author(s): Yao, X., Chong, H.H., Waltersperger, S., Wang, M.T., He, Y.X., Cui, S.
Revision History (Full details and data files)
- Version 1.0: 2014-01-22
Type: Initial release - Version 1.1: 2023-11-08
Changes: Data collection, Database references, Derived calculations, Refinement description
