4GH4

Crystal Structure of Foot and Mouth Disease Virus A22 Serotype

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.00 Å
  • R-Value Work: 0.167 

wwPDB Validation   3D Report Full Report


This is version 1.1 of the entry. See complete history. 


Literature

Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity.

Curry, S., Fry, E., Blakemore, W., Abu-Ghazaleh, R., Jackson, T., King, A., Lea, S., Newman, J., Rowlands, D., Stuart, D.

(1996) Structure 4: 135-145

  • DOI: https://doi.org/10.1016/s0969-2126(96)00017-2
  • Primary Citation of Related Structures:  
    4GH4

  • PubMed Abstract: 

    Foot-and-mouth disease virus (FMDV) is an extremely infectious and antigenically diverse picornavirus of cloven-hoofed animals. Strains of the A22 subtype have been reported to change antigenically when adapted to different growth conditions. To investigate the structural basis of this phenomenon we have determined the structures of two variants of an A22 virus.

    • Organizational Affiliation: 

    Pirbright Laboratory, Institute for Animal Health, Pirbright, Surrey, GU24 0NF, UK.


Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
capsid protein VP1210Foot-and-mouth disease virus AMutation(s): 0 
UniProt
Find proteins for Q6PN23 (Foot-and-mouth disease virus A)
Explore Q6PN23 
Go to UniProtKB:  Q6PN23
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ6PN23
Sequence Annotations
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  • Reference Sequence
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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
capsid protein VP2207Foot-and-mouth disease virus AMutation(s): 0 
UniProt
Find proteins for Q6PN23 (Foot-and-mouth disease virus A)
Explore Q6PN23 
Go to UniProtKB:  Q6PN23
Entity Groups  
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UniProt GroupQ6PN23
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  • Reference Sequence
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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
capsid protein VP3221Foot-and-mouth disease virus AMutation(s): 0 
UniProt
Find proteins for Q9Q2N8 (Foot-and-mouth disease virus A)
Explore Q9Q2N8 
Go to UniProtKB:  Q9Q2N8
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UniProt GroupQ9Q2N8
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  • Reference Sequence
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
capsid protein VP445Foot-and-mouth disease virus AMutation(s): 0 
UniProt
Find proteins for Q9ILY1 (Foot-and-mouth disease virus A22/India/17/77)
Explore Q9ILY1 
Go to UniProtKB:  Q9ILY1
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UniProt GroupQ9ILY1
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.00 Å
  • R-Value Work: 0.167 
  • Space Group: I 2 2 2
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 328.2α = 90
b = 341.8β = 90
c = 363.75γ = 90
Software Package:
Software NamePurpose
CNSrefinement
PDB_EXTRACTdata extraction
MOSFLMdata reduction
ROTAVATAdata scaling
Agrovatadata scaling
X-PLORphasing
X-PLORrefinement

Structure Validation

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View more in-depth experimental data
Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2013-02-20
    Type: Initial release
  • Version 1.1: 2024-02-28
    Changes: Data collection, Database references, Derived calculations, Refinement description