Download MendeleyStructures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.
Moen, S.O., Fairman, J.W., Barnes, S.R., Sullivan, A., Nakazawa-Hewitt, S., Van Voorhis, W.C., Staker, B.L., Lorimer, D.D., Myler, P.J., Edwards, T.E.(2015) Acta Crystallogr Sect F Struct Biol Cryst Commun 71: 609-614
- PubMed: 25945716
- DOI: https://doi.org/10.1107/S2053230X15006883
- Primary Citation of Related Structures:
4F40, 4FZI, 4G5D, 4GIE - PubMed Abstract:
The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 Å for T. cruzi PGF, 1.25 Å for T. cruzi PGF with NADP, 1.6 Å for L. major PGF and 1.8 Å for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (Rfree of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target.
Organizational Affiliation:
Seattle Structural Genomics Center for Infectious Disease, USA.
