3ZYT

Crystal Structure Analysis of Esta from Arthrobacter Sp. Rue61A--an Insight Into Catalytic Promiscuity.

(2014) FEBS Lett 588: 1154

• PubMed: 24613918 Search on PubMed
• DOI: https://doi.org/10.1016/j.febslet.2014.02.045
• Primary Citation of Related Structures:  
  3ZYT


• PubMed Abstract: 
  

  In this article we analyze the reasons for catalytic promiscuity of a type VIII esterase with β-lactamase fold and the ability to cleave β-lactams. We compared the structure of this enzyme to those of an esterase of the same type without any lactamase ability, an esterase with moderate lactamase ability, and a class C β-lactamase with similar fold. Our results show that for these enzymes, the difference in the substrate specificity is sterically driven.

   View More

---

Organizational Affiliation: 

Institute of Molecular Biosciences, University of Graz, A-8010 Graz, Austria. Electronic address: ulrike.wagner@uni-graz.at.