Crystal structure of MEK1 in complex with fragment 18
3ZLX
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 39195.94
    Molecule: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
    Polymer: 1 Type: protein Length: 348
    Chains: A
    EC#: 2.7.12.2   
    Mutation: YES
    Organism: Homo sapiens
    Gene Names: Gene View for MAP2K1 MEK1 PRKMK1
    UniProtKB: Protein Feature View | Search PDB | Q02750  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda  
     
  •   Related PDB Entries Hide
    Identifier Details
    3ZLS   CRYSTAL STRUCTURE OF MEK1 IN COMPLEX WITH FRAGMENT SAR198059 
    3ZLW   CRYSTAL STRUCTURE OF MEK1 IN COMPLEX WITH FRAGMENT 3 
    3ZLY   CRYSTAL STRUCTURE OF MEK1 IN COMPLEX WITH FRAGMENT 8 
    3ZM4   CRYSTAL STRUCTURE OF MEK1 IN COMPLEX WITH FRAGMENT 1 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    5EZ
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    5EZ C14 H15 Cl N2 O2
    7-choro-6-[(3R)-pyrrolidin-3-ylmethoxy]isoquinolin- 1(2H)-one
    5EZ:3ZLX
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    5EZ
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    5EZ
    N/Ain BindingDB
    IC50: 157000 nM - data from BindingMOAD  
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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