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Crystal structure of MEK1 in complex with fragment 3
3ZLW
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 39166.47
    Molecule: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 MAPK/ERK KINASE 1, MEK 1, MEK1
    Polymer: 1 Type: protein Length: 348
    Chains: A
    EC#: 2.7.12.2   
    Mutation: YES
    Organism: Homo sapiens
    Gene Names: Gene View for MAP2K1 MEK1 PRKMK1
    UniProtKB: Protein Feature View | Search PDB | Q02750  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human  
     
  •   Related PDB Entries Hide
    Identifier Details
    3ZLS  CRYSTAL STRUCTURE OF MEK1 IN COMPLEX WITH FRAGMENT SAR198059 
    3ZLX  CRYSTAL STRUCTURE OF MEK1 IN COMPLEX WITH FRAGMENT 18 
    3ZLY  CRYSTAL STRUCTURE OF MEK1 IN COMPLEX WITH FRAGMENT 8 
    3ZM4  CRYSTAL STRUCTURE OF MEK1 IN COMPLEX WITH FRAGMENT 1 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    MT8
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    MT8 C13 H15 N O2
    (1R)-1-hydroxy-1-methyl-2,3,6,7-tetrahydro- 1H,5H-pyrido[3,2,1-ij]quinolin-5-one
    MT8:3ZLW
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    MT8
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    MT8
    N/Ain BindingDB
    IC50: 198000 nM - data from BindingMOAD  
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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