3UIW

Zebrafish Grx2 (APO)

PDB DOI: https://doi.org/10.2210/pdb3UIW/pdb

Classification: OXIDOREDUCTASE
Organism(s): Danio rerio
Expression System: Escherichia coli
Mutation(s): No

Deposited: 2011-11-06 Released: 2013-03-27
Deposition Author(s): McDonough, M.A., Johansson, C.

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 2.60 Å
R-Value Free: 0.250
R-Value Work: 0.189
R-Value Observed: 0.195

wwPDB Validation 3D Report Full Report

Ligand Structure Quality Assessment

This is version 1.1 of the entry. See complete history.

Literature

A New Mode of Iron-sulfur Cluster Coordination in Glutaredoxins is Crucial for Axonogenesis

Brautigam, L., Johansson, C., Kubsch, B., McDonough, M.A., Bill, E., Holmgren, A., Berndt, C.

To be published.

Macromolecule Content

Total Structure Weight: 33.9 kDa
Atom Count: 1,681
Modelled Residue Count: 219
Deposited Residue Count: 308
Unique protein chains: 1

Macromolecules

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(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Glutaredoxin 2	A, B	154	Danio rerio	Mutation(s): 0 Gene Names: Dr.88731, glrx2, zgc:92698
UniProt
Find proteins for Q6DH06 (Danio rerio) Explore Q6DH06 Go to UniProtKB: Q6DH06
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q6DH06
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 2 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
GSH Query on GSH Download Ideal Coordinates CCD File SDF format, chain C [auth A] SDF format, chain E [auth B] MOL2 format, chain C [auth A] MOL2 format, chain E [auth B]	C [auth A], E [auth B]	GLUTATHIONE C₁₀ H₁₇ N₃ O₆ S RWSXRVCMGQZWBV-WDSKDSINSA-N		Interactions Focus chain C [auth A] Focus chain E [auth B] Interactions & Density Focus chain C [auth A] Focus chain E [auth B]
SO4 Query on SO4 Download Ideal Coordinates CCD File SDF format, chain D [auth A] MOL2 format, chain D [auth A]	D [auth A]	SULFATE ION O₄ S QAOWNCQODCNURD-UHFFFAOYSA-L		Interactions Focus chain D [auth A] Interactions & Density Focus chain D [auth A]

Experimental Data & Validation

Experimental Data

Method: X-RAY DIFFRACTION
Resolution: 2.60 Å
R-Value Free: 0.250
R-Value Work: 0.189
R-Value Observed: 0.195
Space Group: H 3 2

Unit Cell:

Length ( Å )	Angle ( ˚ )
a = 92.552	α = 90
b = 92.552	β = 90
c = 167.077	γ = 120

Software Package:

Software Name	Purpose
DENZO	data reduction
SCALEPACK	data scaling
PHASER	phasing
PHENIX	refinement
PDB_EXTRACT	data extraction
CrystalClear	data collection

Structure Validation

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Ligand Structure Quality Assessment

Entry History

Deposition Data

Released Date: 2013-03-27

Deposition Author(s):

McDonough, M.A.

Johansson, C.

Revision History (Full details and data files)

Version 1.0: 2013-03-27
Type: Initial release
Version 1.1: 2023-09-13
Changes: Data collection, Database references, Derived calculations, Refinement description

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Help and Resources

3UIW

Zebrafish Grx2 (APO)

A New Mode of Iron-sulfur Cluster Coordination in Glutaredoxins is Crucial for Axonogenesis

Entity ID: 1

UniProt

Entity Groups

Sequence Annotations

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Experimental Data

Structure Validation

Ligand Structure Quality Assessment

Deposition Data

Revision History (Full details and data files)