3SXO

Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7

PDB DOI: https://doi.org/10.2210/pdb3SXO/pdb

Classification: TRANSFERASE
Organism(s): Mycobacterium tuberculosis
Expression System: Escherichia coli
Mutation(s): No

Deposited: 2011-07-15 Released: 2012-07-25
Deposition Author(s): Kim, K.H., An, D.R., Yoon, J.Y., Kim, H.S., Yoon, H.J., Song, J.S., Im, H.N., Kim, J., Kim, D.J., Lee, S.J., Kim, H.J., Lee, J.Y., Suh, S.W.

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 2.50 Å
R-Value Free: 0.217
R-Value Work: 0.175
R-Value Observed: 0.178

wwPDB Validation 3D Report Full Report

This is version 1.1 of the entry. See complete history.

Literature

Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7

Kim, K.H., An, D.R., Yoon, J.Y., Kim, H.S., Yoon, H.J., Song, J.S., Im, H.N., Kim, J., Kim, D.J., Lee, S.J., Kim, H.J., Lee, J.Y., Suh, S.W.

To be published.

Macromolecule Content

Total Structure Weight: 93.29 kDa
Atom Count: 6,450
Modelled Residue Count: 792
Deposited Residue Count: 856
Unique protein chains: 1

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Enhanced intracellular survival protein	A, B	428	Mycobacterium tuberculosis	Mutation(s): 0 Gene Names: eis, MT2489, MTCY253.04, Rv2416c
UniProt
Find proteins for P9WFK7 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)) Explore P9WFK7 Go to UniProtKB: P9WFK7
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	P9WFK7
Sequence Annotations Expand
Reference Sequence

Experimental Data & Validation

Experimental Data

Method: X-RAY DIFFRACTION
Resolution: 2.50 Å
R-Value Free: 0.217
R-Value Work: 0.175
R-Value Observed: 0.178
Space Group: H 3

Unit Cell:

Length ( Å )	Angle ( ˚ )
a = 174.574	α = 90
b = 174.574	β = 90
c = 122.827	γ = 120

Software Package:

Software Name	Purpose
HKL-2000	data collection
PHASES	phasing
PHENIX	refinement
HKL-2000	data reduction
HKL-2000	data scaling

Structure Validation

View Full Validation Report

Entry History

Deposition Data

Released Date: 2012-07-25

Deposition Author(s):

Revision History (Full details and data files)

Version 1.0: 2012-07-25
Type: Initial release
Version 1.1: 2024-03-20
Changes: Data collection, Database references

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.