Download MendeleyStructural basis of activation and GTP hydrolysis in Rab proteins.
Dumas, J.J., Zhu, Z., Connolly, J.L., Lambright, D.G.(1999) Structure 7: 413-423
- PubMed: 10196122
- DOI: https://doi.org/10.1016/s0969-2126(99)80054-9
- Primary Citation of Related Structures:
3RAB - PubMed Abstract:
Rab proteins comprise a large family of GTPases that regulate vesicle trafficking. Despite conservation of critical residues involved in nucleotide binding and hydrolysis, Rab proteins exhibit low sequence identity with other GTPases, and the structural basis for Rab function remains poorly characterized.
Organizational Affiliation:
Program in Molecular Medicine, University of Massachusetts Medical Center, 373 Plantation Street, Worcester, MA 01605, USA.
