Download MendeleyDesign, Chemical synthesis, Functional characterization and Crystal structure of the sidechain analogue of 1,25-dihydroxyvitamin D3.
Huet, T., Fraga, R., Mourino, A., Moras, D., Rochel, N.To be published.
3OGT
Design, Chemical synthesis, Functional characterization and Crystal structure of the sidechain analogue of 1,25-dihydroxyvitamin D3.
- PDB DOI: https://doi.org/10.2210/pdb3OGT/pdb
- Classification: TRANSCRIPTION
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2010-08-17 Released: 2011-08-17
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.75 Å
- R-Value Free: 0.184
- R-Value Work: 0.160
- R-Value Observed: 0.161
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Vitamin D3 receptor | 259 | Homo sapiens | Mutation(s): 0 Gene Names: VDR, NR1I1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P11473 (Homo sapiens) Explore P11473 Go to UniProtKB: P11473 | |||||
PHAROS: P11473 GTEx: ENSG00000111424 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P11473 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| FMV Query on FMV | B [auth A] | (1S,3R,5Z,7E,14beta,17alpha,20S)-20-[5-(1-hydroxy-1-methylethyl)furan-2-yl]-9,10-secopregna-5,7,10-triene-1,3-diol C28 H40 O4 LQSIVELXOQAADQ-YQCVTLPCSA-N |  | ||
| SO4 Query on SO4 | C [auth A], D [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.75 Å
- R-Value Free: 0.184
- R-Value Work: 0.160
- R-Value Observed: 0.161
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 45.018 | α = 90 |
| b = 51.622 | β = 90 |
| c = 132.818 | γ = 90 |
| Software Name | Purpose |
|---|---|
| MxCuBE | data collection |
| PHENIX | model building |
| PHENIX | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| PHENIX | phasing |
Entry History
Deposition Data
- Released Date: 2011-08-17 Deposition Author(s): Huet, T., Fraga, R., Mourino, A., Moras, D., Rochel, N.
Revision History (Full details and data files)
- Version 1.0: 2011-08-17
Type: Initial release - Version 1.1: 2024-02-21
Changes: Data collection, Database references, Derived calculations
