Download Mendeleya single amino-acid dictates the dynamics of the switch between active and inactive C-Src conformation
Boubeva, R., Pernot, L., Cristiani, A., Moretti, L., Berteotti, A., Perozzo, R., Gervasio, F., Scapozza, L.To be published.
3OEZ
crystal structure of the L317I mutant of the chicken c-Src tyrosine kinase domain complexed with imatinib
- PDB DOI: https://doi.org/10.2210/pdb3OEZ/pdb
- Classification: TRANSFERASE
- Organism(s): Gallus gallus
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2010-08-13 Released: 2011-08-17
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 Å
- R-Value Free: 0.240
- R-Value Work: 0.194
- R-Value Observed: 0.196
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Proto-oncogene tyrosine-protein kinase Src | 286 | Gallus gallus | Mutation(s): 1 Gene Names: SRC EC: 2.7.10.2 |  | |
UniProt | |||||
Find proteins for P00523 (Gallus gallus) Explore P00523 Go to UniProtKB: P00523 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P00523 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| STI Query on STI | C [auth A], F [auth B] | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE C29 H31 N7 O KTUFNOKKBVMGRW-UHFFFAOYSA-N |  | ||
| GOL Query on GOL | E [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| ACT Query on ACT | D [auth A] | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 Å
- R-Value Free: 0.240
- R-Value Work: 0.194
- R-Value Observed: 0.196
- Space Group: P 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 41.895 | α = 79.16 |
| b = 63.426 | β = 90.02 |
| c = 74.145 | γ = 90.19 |
| Software Name | Purpose |
|---|---|
| PHASER | phasing |
| PHENIX | refinement |
| MOSFLM | data reduction |
| SCALA | data scaling |
Entry History
Deposition Data
- Released Date: 2011-08-17 Deposition Author(s): Boubeva, R., Pernot, L., Perozzo, R., Scapozza, L.
Revision History (Full details and data files)
- Version 1.0: 2011-08-17
Type: Initial release - Version 1.1: 2023-09-06
Changes: Data collection, Database references, Derived calculations, Refinement description, Structure summary
