3MPH
The structure of human diamine oxidase complexed with an inhibitor aminoguanidine
- PDB DOI: https://doi.org/10.2210/pdb3MPH/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Homo sapiens
- Expression System: Drosophila melanogaster
- Mutation(s): Yes
- Deposited: 2010-04-27 Released: 2010-09-08
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.05 Å
- R-Value Free: 0.215
- R-Value Work: 0.177
- R-Value Observed: 0.179
wwPDB Validation 3D Report Full Report
This is version 2.1 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Amiloride-sensitive amine oxidase | 731 | Homo sapiens | Mutation(s): 1 Gene Names: ABP1 EC: 1.4.3.22 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P19801 (Homo sapiens) Explore P19801 Go to UniProtKB: P19801 | |||||
PHAROS: P19801 GTEx: ENSG00000002726 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P19801 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Oligosaccharides
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| CU Query on CU | I [auth A], L [auth B] | COPPER (II) ION Cu JPVYNHNXODAKFH-UHFFFAOYSA-N |  | ||
| CA Query on CA | J [auth A], K [auth A], M [auth B], N [auth B] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
| Modified Residues 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Type | Formula | 2D Diagram | Parent |
| AGQ Query on AGQ | A, B | L-PEPTIDE LINKING | C10 H13 N5 O4 |  | TYR |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.05 Å
- R-Value Free: 0.215
- R-Value Work: 0.177
- R-Value Observed: 0.179
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 92.685 | α = 90 |
| b = 94.604 | β = 90 |
| c = 196.051 | γ = 90 |
| Software Name | Purpose |
|---|---|
| SCALA | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| MOSFLM | data reduction |
| REFMAC | phasing |
Entry History
Deposition Data
- Released Date: 2010-09-08 Deposition Author(s): McGrath, A.P., Guss, J.M.
Revision History (Full details and data files)
- Version 1.0: 2010-09-08
Type: Initial release - Version 1.1: 2011-07-13
Changes: Version format compliance - Version 1.2: 2012-04-18
Changes: Derived calculations - Version 1.3: 2014-03-05
Changes: Database references - Version 2.0: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Atomic model, Data collection, Database references, Derived calculations, Structure summary - Version 2.1: 2023-11-01
Changes: Data collection, Database references, Refinement description, Structure summary
