3MB9

Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase

(2011) Biochim Biophys Acta 1810: 879-887

• PubMed: 21684320 Search on PubMed
• DOI: https://doi.org/10.1016/j.bbagen.2011.06.001
• Primary Citation of Related Structures:  
  3LEN, 3M0I, 3M64, 3MB9, 3MC5, 3P2V


• PubMed Abstract: 
  

  Flexibility is a common feature of proteins. For human aldose reductase, a variety of conformers have been observed in crystalline complexes with different inhibitors.

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Organizational Affiliation: 

Philipps-Universität, Department of Pharmaceutical Chemistry, Marburg, Germany.