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Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein
3IT8
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Immune System
    Structure Weight: 335670.17
    Molecule: Tumor necrosis factor
    Polymer: 1 Type: protein Length: 161
    Chains: A, B, C, G, H, I
    Fragment: Tumor necrosis factor, soluble form, UNP residues 82-233
    Organism: Homo sapiens
    Gene Names: Gene View for TNF TNFA TNFSF2
    UniProtKB: Protein Feature View | Search PDB | P01375  
    Molecule: 2L protein
    Polymer: 2 Type: protein Length: 324
    Chains: D, E, F, J, K, L
    Organism: Yaba-like disease virus
    Gene Name: 2L
    UniProtKB: Protein Feature View | Search PDB | Q9DHW0  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Yaba-like disease virus   Taxonomy   Common Name: Yldv Expression System: Trichoplusia ni  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    NAG
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    NAG C8 H15 N O6
    N-ACETYL-D-GLUCOSAMINE
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly 1       
Biological assembly 1 assigned by authors
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  •   Deposition Summary Hide
    Authors:   Yang, Z.,  West Jr., A.P.,  Bjorkman, P.J.

    Deposition:   2009-08-27
    Release:   2009-10-20
    Last Modified (REVDAT):   2011-07-13
     
  •   Revision History    Hide
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    2011-07-13
    Version format compliance
    2011-07-13
    Non-polymer description
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.80
    R-Value: 0.236 (obs.)
    R-Free: 0.266
    Space Group: P 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 101.66 α = 90.00 
    b = 170.29 β = 92.04 
    c = 122.00 γ = 90.00