Download MendeleyStructure of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in complex with the irreversible iodoacetamide inhibitor
Balliano, T.L., Guido, R.V.C., Andricopulo, A.D., Oliva, G.To be published.
3IDS
Structure of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in complex with the irreversible iodoacetamide inhibitor
- PDB DOI: https://doi.org/10.2210/pdb3IDS/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Trypanosoma cruzi
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2009-07-21 Released: 2009-08-11
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.240
- R-Value Work: 0.200
- R-Value Observed: 0.202
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | A [auth C], B [auth D], C [auth A], D [auth B] | 359 | Trypanosoma cruzi | Mutation(s): 0 EC: 1.2.1.12 |  |
UniProt | |||||
Find proteins for P22513 (Trypanosoma cruzi) Explore P22513 Go to UniProtKB: P22513 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P22513 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAD Query on NAD | G [auth D] | NICOTINAMIDE-ADENINE-DINUCLEOTIDE C21 H27 N7 O14 P2 BAWFJGJZGIEFAR-NNYOXOHSSA-N |  | ||
| GOL Query on GOL | F [auth C] H [auth D] I [auth D] K [auth A] L [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| ACM Query on ACM | E [auth C], J [auth A], M [auth B] | ACETAMIDE C2 H5 N O DLFVBJFMPXGRIB-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.240
- R-Value Work: 0.200
- R-Value Observed: 0.202
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 83.121 | α = 90 |
| b = 85.388 | β = 96.42 |
| c = 105.66 | γ = 90 |
| Software Name | Purpose |
|---|---|
| MAR345dtb | data collection |
| MOLREP | phasing |
| PHENIX | refinement |
| MOSFLM | data reduction |
| SCALA | data scaling |
Entry History
Deposition Data
- Released Date: 2009-08-11 Deposition Author(s): Balliano, T.L., Guido, R.V.C., Andricopulo, A.D., Oliva, G.
Revision History (Full details and data files)
- Version 1.0: 2009-08-11
Type: Initial release - Version 1.1: 2011-07-13
Changes: Non-polymer description, Version format compliance - Version 1.2: 2023-09-06
Changes: Data collection, Database references, Derived calculations, Refinement description
