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Src Thr338Ile inhibited in the DFG-Asp-Out conformation
3G6H
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 66109.41
    Molecule: Proto-oncogene tyrosine-protein kinase Src
    Polymer: 1 Type: protein Length: 286
    Chains: A, B
    EC#: 2.7.10.2   
    Fragment: Protein kinase Domain
    Mutation: T338I
    Organism: Gallus gallus
    Gene Name: Gene View for SRC
    UniProtKB: Protein Feature View | Search PDB | P00523  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Gallus gallus   Taxonomy   Common Name: Chicken Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    3G6G   
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    G6H
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    G6H C32 H28 F3 N7 O4
    N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]- 1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}- 3-(trifluoromethyl)benzamide
    G6H:3G6H
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    G6H
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    G6H
    N/Ain BindingDB
    IC50: 4.6 nM - data from BindingMOAD  
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PISA (software)
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