Download MendeleyCharacterization of alpha-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A
Wang, S.F., Tian, G.R., Zhang, W.Z., Jin, J.Y.(2009) Bioorg Med Chem Lett 19: 5009-5011
- PubMed: 19646864
- DOI: https://doi.org/10.1016/j.bmcl.2009.07.060
- Primary Citation of Related Structures:
3FX6 - PubMed Abstract:
Zinc-binding groups (ZBGs) are exhaustively applied in the development of the new inhibitors against a wide variety of physiologically and pathologically important zinc proteases. Here the alpha-nitro ketone was presented as a new ZBG, which is a transition-state analog featured by the unique bifurcated hydrogen bonds at the active site of carboxypeptidase A based on the structural analysis. Introduction of a nitro group at the alpha-position of the ketone could provide more non-covalent interactions without loss of the abilities to form a tetrahedral transition-state analog.
Organizational Affiliation:
Key Laboratory of Biological Resources and Functional Molecules of the Changbai Mountains, Ministry of Education, Yanbian University, Yanji, Jilin, China.
