3EZZ

Crystal Structure of human MKP-2


Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.90 Å
  • R-Value Free: 0.242 
  • R-Value Work: 0.219 
  • R-Value Observed: 0.221 

wwPDB Validation   3D Report Full Report


This is version 1.3 of the entry. See complete history


Literature

Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly.

Jeong, D.G.Jung, S.K.Yoon, T.S.Woo, E.J.Kim, J.H.Park, B.C.Ryu, S.E.Kim, S.J.

(2009) Proteins 76: 763-767


Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Dual specificity protein phosphatase 4
A, B, C, D, E
A, B, C, D, E, F
144Homo sapiensMutation(s): 1 
Gene Names: DUSP4MKP2VH2
EC: 3.1.3.48 (PDB Primary Data), 3.1.3.16 (PDB Primary Data)
UniProt & NIH Common Fund Data Resources
Find proteins for Q13115 (Homo sapiens)
Explore Q13115 
Go to UniProtKB:  Q13115
PHAROS:  Q13115
GTEx:  ENSG00000120875 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ13115
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.90 Å
  • R-Value Free: 0.242 
  • R-Value Work: 0.219 
  • R-Value Observed: 0.221 
  • Space Group: I 4
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 141.557α = 90
b = 141.557β = 90
c = 158.532γ = 90
Software Package:
Software NamePurpose
ADSCdata collection
PHASERphasing
MOSFLMdata reduction
SCALAdata scaling

Structure Validation

View Full Validation Report



Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2009-08-25
    Type: Initial release
  • Version 1.1: 2011-07-13
    Changes: Version format compliance
  • Version 1.2: 2021-11-10
    Changes: Database references, Derived calculations
  • Version 1.3: 2023-11-01
    Changes: Data collection, Refinement description