Download MendeleyCrystal structure of human CYP7A1
Strushkevich, N.V., Tempel, W., Dombrovski, L., Dong, A., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Wilkstrom, M., Bochkarev, A., Park, H.To be published.
3DAX
Crystal structure of human CYP7A1
- PDB DOI: https://doi.org/10.2210/pdb3DAX/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Membrane Protein: Yes OPM
- Deposited: 2008-05-30 Released: 2008-08-05
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.15 Å
- R-Value Free: 0.228
- R-Value Work: 0.189
- R-Value Observed: 0.190
This is version 1.4 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Cytochrome P450 7A1 | 491 | Homo sapiens | Mutation(s): 0 Gene Names: CYP7A1, CYP7 EC: 1.14.13.17 Membrane Entity: Yes |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P22680 (Homo sapiens) Explore P22680 Go to UniProtKB: P22680 | |||||
PHAROS: P22680 GTEx: ENSG00000167910 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P22680 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| HEM Query on HEM | C [auth A], E [auth B] | PROTOPORPHYRIN IX CONTAINING FE C34 H32 Fe N4 O4 KABFMIBPWCXCRK-RGGAHWMASA-L |  | ||
| UNX Query on UNX | D [auth A], F [auth B] | UNKNOWN ATOM OR ION X |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.15 Å
- R-Value Free: 0.228
- R-Value Work: 0.189
- R-Value Observed: 0.190
- Space Group: P 1
- Diffraction Data: https://doi.org/10.18430/m33dax
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 55.339 | α = 64.36 |
| b = 80.159 | β = 75.23 |
| c = 84.937 | γ = 72.17 |
| Software Name | Purpose |
|---|---|
| DENZO | data reduction |
| SCALEPACK | data scaling |
| PHASER | phasing |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| Coot | model building |
| MolProbity | model building |
Entry History
Deposition Data
- Released Date: 2008-08-05 Deposition Author(s): Strushkevich, N.V., Tempel, W., Dombrovski, L., Dong, A., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Wilkstrom, M., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Revision History (Full details and data files)
- Version 1.0: 2008-08-05
Type: Initial release - Version 1.1: 2011-07-13
Changes: Version format compliance - Version 1.2: 2017-10-25
Changes: Refinement description - Version 1.3: 2020-10-21
Changes: Data collection, Derived calculations - Version 1.4: 2023-08-30
Changes: Data collection, Database references, Refinement description
