3D7J

Deposited: 2008-05-21 Released: 2008-10-21
Deposition Author(s): Spoonamore, J.E., Roberts, S.A., Heroux, A., Bandarian, V.

Experimental Data Snapshot

wwPDB Validation 3D Report Full Report

This is version 1.2 of the entry. See complete history.

Literature

(2008) Acta Crystallogr Sect F Struct Biol Cryst Commun 64: 875-879

PubMed Abstract:
The X-ray crystal structure of the 6-pyruvoyltetrahydropterin synthase (PTPS) homolog from Streptomyces coelicolor, SCO 6650, was solved at 1.5 A resolution. SCO 6650 forms a hexameric T-fold that closely resembles other PTPS proteins. The biological activity of SCO 6650 is unknown, but it lacks both a required active-site zinc metal ion and the essential catalytic triad and does not catalyze the PTPS reaction. However, SCO 6650 maintains active-site residues consistent with binding a pterin-like substrate.

Organizational Affiliation

Department of Biochemistry, University of Arizona, Tucson, AZ 85721, USA.

Macromolecule Content

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Uncharacterized protein SCO6650	A, B, C, D, E A, B, C, D, E, F	152	Streptomyces coelicolor	Mutation(s): 0 Gene Names: SCO6650
UniProt
Find proteins for O86696 (Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)) Explore O86696 Go to UniProtKB: O86696
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	O86696
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 2 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
CL Query on CL Download Ideal Coordinates CCD File SDF format, chain I [auth A] SDF format, chain J [auth B] SDF format, chain K [auth D] MOL2 format, chain I [auth A] MOL2 format, chain J [auth B] MOL2 format, chain K [auth D]	I [auth A], J [auth B], K [auth D]	CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M		Interactions Focus chain I [auth A] Focus chain J [auth B] Focus chain K [auth D] Interactions & Density Focus chain I [auth A] Focus chain J [auth B] Focus chain K [auth D]
NA Query on NA Download Ideal Coordinates CCD File SDF format, chain G [auth A] SDF format, chain H [auth A] MOL2 format, chain G [auth A] MOL2 format, chain H [auth A]	G [auth A], H [auth A]	SODIUM ION Na FKNQFGJONOIPTF-UHFFFAOYSA-N		Interactions Focus chain G [auth A] Focus chain H [auth A] Interactions & Density Focus chain G [auth A] Focus chain H [auth A]