Crystal structure of TNF-TNFR2 complex
3ALQ
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Cytokine/cytokine Receptor
    Structure Weight: 216742.40
    Molecule: Tumor necrosis factor
    Polymer: 1 Type: protein Length: 157
    Chains: A, B, C, D, E, F
    Fragment: soluble form
    Mutation: K11M, K65S, K90P, K98R, K112N, K128P
    Organism: Homo sapiens
    Gene Names: Gene View for TNF TNFA TNFSF2
    UniProtKB: Protein Feature View | Search PDB | P01375  
    Molecule: Tumor necrosis factor receptor superfamily member 1B
    Polymer: 2 Type: protein Length: 173
    Chains: R, S, T, U, V, W
    Fragment: residues in UNP 33-205
    Organism: Homo sapiens
    Gene Names: Gene View for TNFRSF1B TNFBR TNFR2
    UniProtKB: Protein Feature View | Search PDB | P20333  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1tnf    
    1tnr    
    2e7a    
    2zjc    
    2zpx    
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    CO
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    CO Co
    COBALT (II) ION
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Mukai, Y.,  Nakamura, T.,  Yamagata, Y.,  Tsutsumi, Y.

    Deposition:   2010-08-06
    Release:   2010-11-17
    Last Modified (REVDAT):   2010-12-01
     
  •   Revision History    Hide
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    2011-07-13
    Version format compliance
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    Resolution[Å]:   3.00
    R-Value: 0.220 (obs.)
    R-Free: 0.282
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 74.47 α = 90.00 
    b = 117.36 β = 90.00 
    c = 246.84 γ = 90.00