POP-OUT | CLOSE
 
Crystal structure of the beta2 adrenergic receptor-Gs protein complex
3SN6
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Signaling Protein/hydrolase
    Structure Weight: 164494.26
    Molecule: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Polymer: 1 Type: protein Length: 380
    Chains: A
    Mutation: G72S
    Organism: Bos taurus
    Gene Names: Gene View for GNAS GNAS1
    UniProtKB: Protein Feature View | Search PDB | P04896  
    Molecule: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Polymer: 2 Type: protein Length: 351
    Chains: B
    Mutation: M1Q
    Organism: Rattus norvegicus
    Gene Name: Gnb1
    UniProtKB: Protein Feature View | Search PDB | P54311  
    Molecule: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Polymer: 3 Type: protein Length: 68
    Chains: G
    Organism: Bos taurus
    Gene Name: Gene View for GNG2
    UniProtKB: Protein Feature View | Search PDB | P63212  
    Molecule: Lysozyme, Beta-2 adrenergic receptor
    Polymer: 4 Type: protein Length: 514
    Chains: R
    EC#: 3.2.1.17   
    Mutation: C54T, C97A, M96T, M98T, N187E
    Organism: Homo sapiens Enterobacteria phage T4
    Gene Names: E Gene View for ADRB2 ADRB2R B2AR
    UniProtKB: Protein Feature View | Search PDB | P00720  

    UniProtKB: Protein Feature View | Search PDB | P07550  
    Molecule: Camelid antibody VHH fragment
    Polymer: 5 Type: protein Length: 138
    Chains: N
    Organism: Lama glama
    Membrane Protein:   Source: mpstruc
    ALPHA-HELICAL
    G Protein-Coupled Receptors (GPCRs)
    β2 adrenergic receptor
     
  •   Structure Validation Hide

    Download full validation report    

     

  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Bos taurus   Taxonomy   Common Name: Bovine,cow,domestic cattle,domestic cow Expression System: Spodoptera frugiperda  
    Polymer: 2
    Scientific Name: Rattus norvegicus   Taxonomy   Common Name: Brown rat,rat,rats Expression System: Spodoptera frugiperda  
    Polymer: 3
    Scientific Name: Bos taurus   Taxonomy   Common Name: Bovine,cow,domestic cattle,domestic cow Expression System: Spodoptera frugiperda  
    Polymer: 4
    Scientific Name: Enterobacteria phage t4, homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda  
    Polymer: 5
    Scientific Name: Lama glama   Taxonomy   Expression System: Escherichia coli  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    P0G
    Search 
    Download 
    P0G C21 H26 N2 O4
    8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}- 1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin- 3(4H)-one
    P0G:3SN6
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors
Downloadable viewers: