Download MendeleyDual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs.
Stanfield, R., Cabezas, E., Satterthwait, A., Stura, E., Profy, A., Wilson, I.(1999) Structure 7: 131-142
- PubMed: 10368281
- DOI: https://doi.org/10.1016/s0969-2126(99)80020-3
- Primary Citation of Related Structures:
1F58, 2F58, 3F58 - PubMed Abstract:
The third hypervariable (V3) loop of HIV-1 gp120 has been termed the principal neutralizing determinant (PND) of the virus and is involved in many aspects of virus infectivity. The V3 loop is required for viral entry into the cell via membrane fusion and is believed to interact with cell surface chemokine receptors on T cells and macrophages. Sequence changes in V3 can affect chemokine receptor usage, and can, therefore, modulate which types of cells are infected. Antibodies raised against peptides with V3 sequences can neutralize laboratory-adapted strains of the virus and inhibit syncytia formation. Fab fragments of these neutralizing antibodies in complex with V3 loop peptides have been studied by X-ray crystallography to determine the conformation of the V3 loop.
Organizational Affiliation:
The Scripps Research Institute, Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla CA 92037, USA.
