A possible role for metallic ions in the carbohydrate cluster recognition displayed by a lewis y specific antibody.
Farrugia, W., Scott, A.M., Ramsland, P.A.(2009) PLoS One 4: e7777-e7777
- PubMed: 19901987 
- DOI: https://doi.org/10.1371/journal.pone.0007777
- Primary Citation of Related Structures:  
3EYV - PubMed Abstract: 
Lewis Y (Le(y)) is a blood group-related carbohydrate that is expressed at high surface densities on the majority of epithelial carcinomas and is a promising target for antibody-based immunotherapy. A humanized Le(y)-specific antibody (hu3S193) has shown encouraging safety, pharmacokinetic and tumor-targeting properties in recently completed Phase I clinical trials.
Organizational Affiliation: 
Centre for Immunology, Burnet Institute, Melbourne, Victoria, Australia.