X-ray structure of HIV-1 protease in situ product complex
3DOX
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 22740.83
    Molecule: HIV-1 PROTEASE
    Polymer: 1 Type: protein Length: 203
    Chains: A
    EC#: 3.4.23.16   
    Mutation: C95M, C1095A
    Details: TETHERED DIMER LINKED BY GGSSG
    Organism: HIV-1 M:B_HXB2R
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P04585  
    Molecule: A PEPTIDE SUBSTRATE-SQNY
    Polymer: 2 Type: protein Length: 4
    Chains: P
    Molecule: A PEPTIDE SUBSTRATE-PIV
    Polymer: 3 Type: protein Length: 3
    Chains: Q
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus type 1 (isolate hxb2 group m subtype b)   Taxonomy   Common Name: Hiv-1, hiv-1 m:b_hxb2r Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct   Taxonomy    
    Polymer: 3
    Scientific Name: Synthetic construct   Taxonomy    
     
  •   Related PDB Entries Hide
    Identifier Details
    1G6L    
    1LV1    
    2NPH    
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Hosur, M.V.,  Ferrer, J.-L.,  Das, A.,  Prashar, V.,  Bihani, S.

    Deposition:   2008-07-07
    Release:   2008-09-09
    Last Modified (REVDAT):   2009-02-03
     
  •   Revision History    Hide
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.00
    R-Value: 0.197 (obs.)
    R-Free: 0.236
    Space Group: P 61
    Unit Cell:
      Length [Å] Angles [°]
    a = 62.38 α = 90.00 
    b = 62.38 β = 90.00 
    c = 82.00 γ = 120.00