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Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP
 
 
DOI:10.2210/pdb3d94/pdb
3D94
 
Primary Citation
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  •  
    Move Section Molecular Description Hide
    Classification: Transferase
    Structure Weight: 34978.50
     
    Molecule:Insulin-like growth factor 1 receptor beta chain
    Polymer:1Type:polypeptide(L)Length:301
    Chains:A
    EC#:2.7.1.112 Go to IUBMB EC entry  2.7.10.1 Go to IUBMB EC entry  
    Fragment:Protein Kinase domain
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens Go to NCBI Taxonomy entry Common Name: Human Expression System: Spodoptera frugiperda  
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    CA     CALCIUM ION Ca 3DLigand Explorer Link out to Ligand Expos:CA Link out to SuperLigands:CA Link out to SuperHapten:CA
    D94     3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]- 1-(2-phenylquinolin-7-yl)imidazo
    [1,5-a]pyrazin- 8-amine     		C30 H31 N7 3DLigand Explorer Link out to Ligand Expos:D94 Link out to SuperLigands:D94 Link out to SuperHapten:D94
     
     
  •  
    Move Section Modified Residues Hide
    Identifier Name Formula Interaction View Links
    MHO S-OXYMETHIONINE (parent: MET)(type: lPeptideLinking) C5 H11 N O3 S 3D Ligand Explorer Link out to Ligand Expos:MHO Link out to SuperLigands:MHO Link out to SuperHapten:MHO 2D
     
     
  •  
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Biological assembly assigned by authors and generated by PISA (software)
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Wu, J.,   Li, W.,   Miller, W.T.,   Hubbard, S.R.

    Deposition:   2008-05-26
    Release:   2008-07-29
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 2.30
    R-Value: 0.200 (obs.)
    R-Free: 0.236
    Space Group: H 3 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 208.18 α = 90.00 
    b = 208.18 β = 90.00 
    c = 50.85 γ = 120.00