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PCSK9:EGF-A complex
3BPS
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Hydrolase/lipid Transport
    Structure Weight: 77858.43
    Molecule: Proprotein convertase subtilisin/kexin type 9
    Polymer: 1 Type: protein Length: 100
    Chains: P
    EC#: 3.4.21   
    Fragment: Prodomain, UNP residues 53-152
    Organism: Homo sapiens
    Gene Names: Gene View for PCSK9 NARC1 PSEC0052
    UniProtKB: Protein Feature View | Search PDB | Q8NBP7  
    Molecule: Proprotein convertase subtilisin/kexin type 9
    Polymer: 2 Type: protein Length: 540
    Chains: A
    EC#: 3.4.21   
    Fragment: Catalytic domain, UNP residues 153-692
    Organism: Homo sapiens
    Gene Names: Gene View for PCSK9 NARC1 PSEC0052
    UniProtKB: Protein Feature View | Search PDB | Q8NBP7  
    Molecule: Low-density lipoprotein receptor
    Polymer: 3 Type: protein Length: 83
    Chains: E
    Fragment: EGF-like 1, EGF-like 2 domains, UNP residues 314-393
    Organism: Homo sapiens
    Gene Name: Gene View for LDLR
    UniProtKB: Protein Feature View | Search PDB | P01130  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 3
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    CA
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    CA Ca
    CALCIUM ION
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors
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  •   MyPDB Personal Annotations Hide
     
  •   Deposition Summary Hide
    Authors:   Kwon, H.J.

    Deposition:   2007-12-19
    Release:   2008-02-12
    Last Modified (REVDAT):   2011-07-13
     
  •   Revision History    Hide
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    2011-07-13
    Flag residual B-value
    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.41
    R-Value: 0.205 (obs.)
    R-Free: 0.240
    Space Group: P 41 21 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 116.95 α = 90.00 
    b = 116.95 β = 90.00 
    c = 134.88 γ = 90.00