TNFR1 selectve TNF mutant; R1-6
2ZJC
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Cytokine
    Structure Weight: 51336.00
    Molecule: Tumor necrosis factor
    Polymer: 1 Type: protein Length: 157
    Chains: A, B, C
    Fragment: R1-6, UNP residues 77-233
    Mutation: K11M, K65S, L29K, R31A, R32G, K90P, K98R, K112N, K128P, E146S, S147T
    Organism: Homo sapiens
    Gene Names: Gene View for TNF TNFA TNFSF2
    UniProtKB: Protein Feature View | Search PDB | P01375  
     
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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
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    Identifier Details
    2E7A   TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    GOL
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    GOL C3 H8 O3
    GLYCEROL
     
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Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Mukai, Y.,  Yamagata, Y.,  Tsutsumi, Y.

    Deposition:   2008-03-05
    Release:   2009-01-20
    Last Modified (REVDAT):   2011-07-13
     
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    2011-07-13
    Version format compliance
    2011-07-13
    Flag residual B-value
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.50
    R-Value: 0.209 (obs.)
    R-Free: 0.272
    Space Group: H 3
    Unit Cell:
      Length [Å] Angles [°]
    a = 135.87 α = 90.00 
    b = 135.87 β = 90.00 
    c = 58.02 γ = 120.00