2Z81
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
- PDB DOI: https://doi.org/10.2210/pdb2Z81/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Mus musculus, Eptatretus burgeri
- Expression System: Trichoplusia ni
- Mutation(s): No 
- Deposited: 2007-08-30 Released: 2007-10-02 
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.232 
- R-Value Work: 0.213 
- R-Value Observed: 0.213 
This is version 2.1 of the entry. See complete history. 
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Toll-like receptor 2, Variable lymphocyte receptor B | 549 | Mus musculus, Eptatretus burgeri This entity is chimeric | Mutation(s): 0  Gene Names: Tlr2, VLRB | ||
UniProt | |||||
Find proteins for Q9QUN7 (Mus musculus) Explore Q9QUN7  Go to UniProtKB:  Q9QUN7 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q9QUN7 | ||||
Sequence AnnotationsExpand | |||||
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Oligosaccharides
Small Molecules
Ligands 2 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
PCJ Query on PCJ | E [auth A] | (2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE C54 H105 N O6 S GBQDHEZHWNJSLG-OKPYTHRESA-N | |||
NAG Query on NAG | D [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.232 
- R-Value Work: 0.213 
- R-Value Observed: 0.213 
- Space Group: P 21 21 21
Unit Cell:
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 83.303 | α = 90 |
b = 81.549 | β = 90 |
c = 98.961 | γ = 90 |
Software Name | Purpose |
---|---|
HKL-2000 | data collection |
PHASER | phasing |
CNS | refinement |
HKL-2000 | data reduction |
SCALEPACK | data scaling |
Entry History 
Deposition Data
Revision History (Full details and data files)
- Version 1.0: 2007-10-02
Type: Initial release - Version 1.1: 2011-07-13
Changes: Non-polymer description, Version format compliance - Version 1.2: 2017-08-16
Changes: Refinement description, Source and taxonomy - Version 2.0: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Advisory, Atomic model, Data collection, Database references, Derived calculations, Structure summary - Version 2.1: 2023-11-01
Changes: Data collection, Database references, Refinement description, Structure summary