Download MendeleyNon-Canonical Amino Acids for Click Chemistry Reactions Incorporated in Human Annexin V
Debela, M., Merkel, L., Goettig, P., Budisa, N.To be published.
2XO2
Human Annexin V with incorporated Methionine analogue Azidohomoalanine
- PDB DOI: https://doi.org/10.2210/pdb2XO2/pdb
- Classification: MEMBRANE BINDING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2010-08-09 Released: 2011-08-03
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.80 Å
- R-Value Free: 0.296
- R-Value Work: 0.274
- R-Value Observed: 0.274
wwPDB Validation 3D Report Full Report
This is version 2.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| ANNEXIN A5 | 320 | Homo sapiens | Mutation(s): 8 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P08758 (Homo sapiens) Explore P08758 Go to UniProtKB: P08758 | |||||
PHAROS: P08758 GTEx: ENSG00000164111 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P08758 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 4 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SO4 Query on SO4 | E [auth A], F [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
| CA Query on CA | B [auth A], C [auth A] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
| CL Query on CL | G [auth A] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |  | ||
| NA Query on NA | D [auth A] | SODIUM ION Na FKNQFGJONOIPTF-UHFFFAOYSA-N |  | ||
| Modified Residues 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Type | Formula | 2D Diagram | Parent |
| AZH Query on AZH | A | L-PEPTIDE LINKING | C4 H9 N4 O2 |  | ALA |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.80 Å
- R-Value Free: 0.296
- R-Value Work: 0.274
- R-Value Observed: 0.274
- Space Group: H 3
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 152.708 | α = 90 |
| b = 152.708 | β = 90 |
| c = 33.603 | γ = 120 |
| Software Name | Purpose |
|---|---|
| CNS | refinement |
| MOSFLM | data reduction |
| SCALA | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2011-08-03 Deposition Author(s): Debela, M., Merkel, L., Goettig, P., Budisa, N.
Revision History (Full details and data files)
- Version 1.0: 2011-08-03
Type: Initial release - Version 2.0: 2019-04-24
Changes: Advisory, Data collection, Derived calculations, Other, Polymer sequence - Version 2.1: 2023-12-20
Changes: Advisory, Data collection, Database references, Derived calculations, Other, Refinement description
