Electron Tomography of Cryofixed, Isometrically Contracting Insect Flight Muscle Reveals Novel Actin-Myosin Interactions
Wu, S., Liu, J., Reedy, M.C., Tregear, R.T., Winkler, H., Franzini-Armstrong, C., Sasaki, H., Lucaveche, C., Goldman, Y.E., Reedy, M.K., Taylor, K.A.(2010) PLoS One 5: 12643
- PubMed: 20844746 
- DOI: https://doi.org/10.1371/journal.pone.0012643
- Primary Citation of Related Structures:  
2W49, 2W4A, 2W4G, 2W4T - PubMed Abstract: 
Isometric muscle contraction, where force is generated without muscle shortening, is a molecular traffic jam in which the number of actin-attached motors is maximized and all states of motor action are trapped with consequently high heterogeneity. This heterogeneity is a major limitation to deciphering myosin conformational changes in situ.
Organizational Affiliation: 
Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America.