Download MendeleyTetrahydroisoquinoline Amide Substituted Phenyl Pyrazoles as Selective Bcl-2 Inhibitors.
Porter, J., Payne, A., De Candole, B., Ford, D., Hutchinson, B., Trevitt, G., Turner, J., Edwards, C., Watkins, C., Whitcombe, I., Davis, J., Stubberfield, C.(2009) Bioorg Med Chem Lett 19: 230
- PubMed: 19027294
- DOI: https://doi.org/10.1016/j.bmcl.2008.10.113
- Primary Citation of Related Structures:
2W3L - PubMed Abstract:
Anti-apoptotic Bcl-2 protects cells from apoptosis by binding to pro-apoptotic members of the Bcl-2 family thereby playing a role in tumour survival in response to chemo- or radiation therapy. We describe a series of phenyl pyrazoles that have high affinity for Bcl-2 and rationalise the observed SAR by means of an X-ray crystal structure.
Organizational Affiliation:
UCB Celltech, 216 Bath Road, Slough, United Kingdom. john.porter@ucb-group.com
