2R55

Human StAR-related lipid transfer protein 5

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.50 Å
  • R-Value Free: 0.276 
  • R-Value Work: 0.232 
  • R-Value Observed: 0.236 

wwPDB Validation   3D Report Full Report


This is version 1.3 of the entry. See complete history. 


Literature

Comparative structural analysis of lipid binding START domains.

Thorsell, A.G., Lee, W.H., Persson, C., Siponen, M.I., Nilsson, M., Busam, R.D., Kotenyova, T., Schuler, H., Lehtio, L.

(2011) PLoS One 6: e19521-e19521

  • DOI: https://doi.org/10.1371/journal.pone.0019521
  • Primary Citation of Related Structures:  
    2PSO, 2R55, 3FO5, 3P0L

  • PubMed Abstract: 

    Steroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind. These domains can transport ligands to facilitate lipid exchange between biological membranes, and they have been postulated to modulate the activity of other domains of the protein in response to ligand binding. More than a dozen human genes encode START domains, and several of them are implicated in a disease.

    • Organizational Affiliation: 

    Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden.


Macromolecules
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(by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
StAR-related lipid transfer protein 5
A, B
231Homo sapiensMutation(s): 0 
Gene Names: STARD5
UniProt & NIH Common Fund Data Resources
Find proteins for Q9NSY2 (Homo sapiens)
Explore Q9NSY2 
Go to UniProtKB:  Q9NSY2
PHAROS:  Q9NSY2
GTEx:  ENSG00000172345 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ9NSY2
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.50 Å
  • R-Value Free: 0.276 
  • R-Value Work: 0.232 
  • R-Value Observed: 0.236 
  • Space Group: P 65
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 62.87α = 90
b = 62.87β = 90
c = 214.93γ = 120
Software Package:
Software NamePurpose
REFMACrefinement
ProDCdata collection
XDSdata reduction
XSCALEdata scaling
MOLREPphasing

Structure Validation

View Full Validation Report



View more in-depth experimental data
Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2007-09-18
    Type: Initial release
  • Version 1.1: 2011-07-13
    Changes: Advisory, Version format compliance
  • Version 1.2: 2011-09-21
    Changes: Database references
  • Version 1.3: 2023-08-30
    Changes: Data collection, Database references, Refinement description