Structure of the HCV NS3/4A Protease Inhibitor CVS4819     DOI:10.2210/pdb2oc1/pdb

2OC1 Display Files close FASTA Sequence PDB File PDB File (Header) mmCIF File mmCIF File (Header) PDBML/XML File PDBML/XML File (Header) Download Files close FASTA Sequence PDB File (Text) PDB File (gz) mmCIF File mmCIF File (gz) PDBML/XML File PDBML/XML File (gz) Structure Factor (Text) Structure Factor (gz) Biological Assembly (gz) (A) Print this Page Share this Page close Email Delicious Stumble Google More... Link this Page

Primary Citation       Related Citations in PDB Entry (REMARK 1) Hide       Molecular Description Hide Classification: Viral Protein Structure Weight: 48014.29   Molecule: Hepatitis C virus Polymer: 1 Type: polypeptide(L) Length: 200 Chains: A, C Molecule: Hepatitis C virus Polymer: 2 Type: polypeptide(L) Length: 23 Chains: B, D Mutation: C22S       Source Hide Polymer: 1 Scientific Name: Hepatitis c virus Expression System: Escherichia coli   Polymer: 2 Scientific Name: Synthetic construct         Related PDB Entries Hide Id Details 1A1R  Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.  2A4G  HEPATITIS C VIRUS NS3-4A SERINE PROTEASE INHIBITORS. SAR OF P2' MOIETY WITH IMPROVED POTENCY.  2A4Q  SYNTHESIS AND BIOLOGICAL ACTIVITY OF MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS (HCV) NS3 PROTEASE  2A4R  HEPATITIS C VIRUS NS3-4A SERINE PROTEASE INHIBITORS: USE OF A P2-P1 CYCLOPROPYL ALANINE COMBINATION FOR IMPROVED POTENCY.  2F9V  DEPEPTIDIZATION EFFORTS ON P3-P2 A-KETOAMIDE INHIBITORS OF HCV NS3-4A SERINE PROTEASE: EFFECT ON HCV REPLICON ACTIVITY.  2FM2  MUTATIONS CONFERRING RESISTANCE TO SCH6, A NOVEL HEPATITIS C VIRUS NS3/4A PROTEASE INHIBITOR REDUCED RNA REPLICATION FITNESS AND PARTIAL RESCUE BY SECOND SITE MUTATIONS        Ligand Chemical Component Hide Identifier Name Formula Interaction View HU2     (2S)-({N-[(3S)-3-({N-[(2S,4E)-2-ISOPROPYL- 7-METHYLOCT-4-ENOYL]-L-LEUCYL}AMINO) -2-OXOHEXANOYL]GLYCYL}AMINO)(PHENYL)ACETIC ACID C34 H52 N4 O7 Ligand Explorer ZN     ZINC ION Zn Ligand Explorer       Derived Data Hide CATH Classification v3.3.0 - (4 Domains) PFAM Classification - (4 Domains)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors         Deposition Summary Hide Authors:   Prongay, A.J.,   Guo, Z.,   Yao, N.,   Fischmann, T.,   Strickland, C.,   Myers, Jr.,   J.,   Weber, P.C.,   Malcolm, B.,   Beyer, B.M.,   Ingram, R.,   Pichardo, J.,   Hong, Z.,   Prosise, W.W.,   Ramanathan, L.,   Taremi, S.S.,   Yarosh-Tomaine, T.,   Zhang, R.,   Senior, M.,   Yang, R.,   Arasappan, A.,   Bennett, F.,   Bogen, S.F.,   Chen, K.,   Jao, E.,   Liu, Y.,   Love, R.G.,   Saksena, A.K.,   Venkatraman, S.,   Girijavallabhan, V.,   Njoroge, F.G.,   Madison, V. Deposition:   2006-12-20 Release:   2007-07-31 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:   Resolution[Å]: 2.70 R-Value: 0.189 (work) R-Free: 0.259 Space Group: H 3 2 Unit Cell:   Length [Å] Angles [°] a = 222.94 α = 90.00  b = 222.94 β = 90.00  c = 75.16 γ = 120.00