Download MendeleyGenetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.
Rath, P., Huang, C., Wang, T., Wang, T., Li, H., Prados-Rosales, R., Elemento, O., Casadevall, A., Nathan, C.F.(2013) Proc Natl Acad Sci U S A 110: E4790-E4797
- PubMed: 24248369
- DOI: https://doi.org/10.1073/pnas.1320118110
- Primary Citation of Related Structures:
2M5Y - PubMed Abstract:
Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."
Organizational Affiliation:
Departments of Immunology and Microbiology and Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065.
