2M01

Solution structure of Kunitz-type neurotoxin LmKKT-1a from scorpion venom


Experimental Data Snapshot

  • Method: SOLUTION NMR
  • Conformers Calculated: 100 
  • Conformers Submitted: 20 
  • Selection Criteria: structures with the lowest energy 

wwPDB Validation   3D Report Full Report


This is version 1.1 of the entry. See complete history


Literature

Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins.

Chen, Z.Luo, F.Feng, J.Yang, W.Zeng, D.Zhao, R.Cao, Z.Liu, M.Li, W.Jiang, L.Wu, Y.

(2013) PLoS One 8: e60201-e60201

  • DOI: https://doi.org/10.1371/journal.pone.0060201
  • Primary Citation of Related Structures:  
    2M01

  • PubMed Abstract: 

    Recently, a new subfamily of long-chain toxins with a Kunitz-type fold was found in scorpion venom glands. Functionally, these toxins inhibit protease activity and block potassium channels. However, the genomic organization and three-dimensional (3-D) structure of this kind of scorpion toxin has not been reported.


  • Organizational Affiliation

    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, PR China.


Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Protease inhibitor LmKTT-1a59Lychas mucronatusMutation(s): 0 
UniProt
Find proteins for P0DJ46 (Lychas mucronatus)
Explore P0DJ46 
Go to UniProtKB:  P0DJ46
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP0DJ46
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: SOLUTION NMR
  • Conformers Calculated: 100 
  • Conformers Submitted: 20 
  • Selection Criteria: structures with the lowest energy 

Structure Validation

View Full Validation Report



Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2013-11-13
    Type: Initial release
  • Version 1.1: 2023-06-14
    Changes: Data collection, Database references, Other