2K6V

Solution structures of apo Sco1 protein from Thermus Thermophilus


Experimental Data Snapshot

  • Method: SOLUTION NMR
  • Conformers Calculated: 31 
  • Conformers Submitted: 31 
  • Selection Criteria: structures with the lowest energy 

wwPDB Validation   3D Report Full Report


This is version 1.2 of the entry. See complete history


Literature

Mechanism of Cu(A) assembly.

Abriata, L.A.Banci, L.Bertini, I.Ciofi-Baffoni, S.Gkazonis, P.Spyroulias, G.A.Vila, A.J.Wang, S.

(2008) Nat Chem Biol 4: 599-601

  • DOI: https://doi.org/10.1038/nchembio.110
  • Primary Citation of Related Structures:  
    2K6V, 2K6W, 2K6Y, 2K6Z, 2K70

  • PubMed Abstract: 

    Copper is essential for proper functioning of cytochrome c oxidases, and therefore for cellular respiration in eukaryotes and many bacteria. Here we show that a new periplasmic protein (PCu(A)C) selectively inserts Cu(I) ions into subunit II of Thermus thermophilus ba(3) oxidase to generate a native Cu(A) site. The purported metallochaperone Sco1 is unable to deliver copper ions; instead, it works as a thiol-disulfide reductase to maintain the correct oxidation state of the Cu(A) cysteine ligands.


  • Organizational Affiliation

    Instituto de Biología Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, (S2002LRK) Rosario, Argentina.


Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Putative cytochrome c oxidase assembly protein172Thermus thermophilus HB8Mutation(s): 0 
Gene Names: TTHA1942
UniProt
Find proteins for Q5SGY8 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
Explore Q5SGY8 
Go to UniProtKB:  Q5SGY8
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ5SGY8
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: SOLUTION NMR
  • Conformers Calculated: 31 
  • Conformers Submitted: 31 
  • Selection Criteria: structures with the lowest energy 

Structure Validation

View Full Validation Report



Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2008-09-09
    Type: Initial release
  • Version 1.1: 2011-07-13
    Changes: Version format compliance
  • Version 1.2: 2022-03-16
    Changes: Data collection, Database references, Derived calculations