Download MendeleyNMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.
Zhou, Z., Feng, H., Hansen, D.F., Kato, H., Luk, E., Freedberg, D.I., Kay, L.E., Wu, C., Bai, Y.(2008) Nat Struct Mol Biol 15: 868-869
- PubMed: 18641662
- DOI: https://doi.org/10.1038/nsmb.1465
- Primary Citation of Related Structures:
2JSS - PubMed Abstract:
The NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B has been determined. Chz1 forms a long irregular chain capped by two short alpha-helices, and uses both positively and negatively charged residues to stabilize the histone dimer. A molecular model that docks Chz1 onto the nucleosome has implications for its potential functions.
Organizational Affiliation:
Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
