CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN
2IUG
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 13939.70
    Molecule: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
    Polymer: 1 Type: protein Length: 120
    Chains: A
    Fragment: N-TERMINAL SH2 DOMAIN, RESIDUES 321-440
    Organism: Homo sapiens
    Gene Names: Gene View for PIK3R1 GRB1
    UniProtKB: Protein Feature View | Search PDB | P27986  
     
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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
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    Identifier Details
    1A0N   NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, FAMILY OF 25 STRUCTURES 
    1AZG   NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE 
    1H9O   PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A 
    1PBW   STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN 
    1PHT   PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN, RESIDUES 1-85 
    1PIC   PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE 
    1PKS   PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) (SH3 DOMAIN) (NMR, MINIMIZED AVERAGE STRUCTURE) 
    1PKT   PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) (SH3 DOMAIN) (NMR, 30 STRUCTURES) 
    2IUH   CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N -TERMINAL SH2 DOMAIN IN COMPLEX WITH C- KIT PHOSPHOTYROSYL PEPTIDE 
    2IUI   CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N -TERMINAL SH2 DOMAIN IN COMPLEX WITH PDGFR PHOSPHOTYROSYL PEPTIDE 
     
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Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PQS (software)
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  •   Deposition Summary Hide
    Authors:   Nolte, R.T.,  Eck, M.J.,  Schlessinger, J.,  Shoelson, S.E.,  Harrison, S.C.

    Deposition:   2006-06-03
    Release:   2006-06-06
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   1.89
    R-Value: 0.192 (obs.)
    R-Free: 0.289
    Space Group: P 41 21 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 57.12 α = 90.00 
    b = 57.12 β = 90.00 
    c = 112.10 γ = 90.00